INT105326

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Context Info
Confidence 0.44
First Reported 2002
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.76
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1) enzyme binding (Grin1) cytoplasm (Grin1)
Grin1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 76 100.00 Very High Very High Very High
gABA 1 99.12 Very High Very High Very High
Neuropathic pain 2 98.16 Very High Very High Very High
metalloproteinase 17 92.92 High High
Thalamus 8 92.40 High High
monoamine 4 89.28 High High
Kinase C 1 80.32 Quite High
Serotonin 2 75.00 Quite High
fluoxetine 2 65.52 Quite High
Inflammatory stimuli 1 64.08 Quite High
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 1 99.16 Very High Very High Very High
Neuropathic Pain 9 98.16 Very High Very High Very High
Colitis 23 92.96 High High
INFLAMMATION 29 64.08 Quite High
Injury 9 58.24 Quite High
Dyspepsia 10 56.80 Quite High
Peripheral Neuropathy 1 43.48 Quite Low
Nociception 13 39.36 Quite Low
Pain 2 25.00 Low Low
Sleep Disorders 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the study indicated that ER retention signals in the alternatively spliced C-terminal domain of the NR1 subunit control release of NR1 from ER and is regulated by PKC phosphorylation [43].
Regulation (control) of Localization (release) of NR1
1) Confidence 0.44 Published 2006 Journal Mol Pain Section Body Doc Link PMC1402265 Disease Relevance 0.44 Pain Relevance 0.27
Putative mechanisms for mediating this change include alterations of GABA-ergic systems and/or plasticity related to alterations in N-methyl-D-aspartate receptor activation and nitric oxide release related to afferent hyperactivity induced by neuropathic pain.
Regulation (alterations) of Localization (release) of N-methyl-D-aspartate receptor associated with gaba, nmda receptor, neuropathic pain and attention deficit hyperactivity disorder
2) Confidence 0.25 Published 2002 Journal Pain Section Abstract Doc Link 12237215 Disease Relevance 0.32 Pain Relevance 0.69
PKC induced alteration of NR1 subunits is not dependent on MMP-activity
Neg (not) Regulation (dependent) of Localization (alteration) of NR1
3) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0 Pain Relevance 0.20

General Comments

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