INT105327

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Context Info
Confidence 0.06
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.85
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ncoa2) Golgi apparatus (Ncoa2) nucleus (Ncoa2)
DNA binding (Ncoa2) cytoplasm (Ncoa2) signal transducer activity (Ncoa2)
Ncoa2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 42 90.92 High High
Inflammatory response 10 74.32 Quite High
ischemia 14 54.16 Quite High
palliative 1 40.64 Quite Low
antagonist 8 6.88 Low Low
agonist 14 5.00 Very Low Very Low Very Low
bradykinin 10 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Prostate Cancer 5 99.48 Very High Very High Very High
Reperfusion Injury 33 91.84 High High
INFLAMMATION 53 90.92 High High
Embryonic Lethality 3 87.16 High High
Injury 3 81.12 Quite High
Metastasis 1 79.72 Quite High
Death 7 76.08 Quite High
Apoptosis 8 73.88 Quite High
Targeted Disruption 26 62.28 Quite High
Cv Unclassified Under Development 13 54.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies on the role of germ-line deletion of coactivators SRC-1, SRC-2, and SRC-3 in the mouse revealed that none of these are essential for PPAR?
Positive_regulation (coactivators) of SRC-2
1) Confidence 0.06 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.28 Pain Relevance 0
Furthermore, activation of the Th2 transcriptional factor GATA-3 followed by IL-4, IL-5, IL-6, IL-10 and IL-13 production was shown to be protective, whereas higher expression of the transcriptional factor T-bet, and IL-12, IL-1?
Positive_regulation (activation) of transcriptional factor
2) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.16 Pain Relevance 0.21
The three coactivators, TIF-2, SRC-1 and RAC3, are up-regulated in relapsed prostate cancer.
Positive_regulation (up-regulated) of TIF-2 associated with prostate cancer
3) Confidence 0.01 Published 2002 Journal Endocr. Relat. Cancer Section Abstract Doc Link 12237244 Disease Relevance 0.41 Pain Relevance 0

General Comments

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