INT10533

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Context Info
Confidence 0.42
First Reported 1986
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 24
Total Number 26
Disease Relevance 6.59
Pain Relevance 9.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Trib3) nucleus (Trib3) enzyme binding (Trib3)
kinase activity (Trib3)
Anatomy Link Frequency
neurons 6
dorsal root ganglion 6
smooth muscle 2
brain 2
striatum 2
Trib3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 45 100.00 Very High Very High Very High
Anterior cingulate cortex 37 100.00 Very High Very High Very High
Lasting pain 19 100.00 Very High Very High Very High
Pain 25 99.96 Very High Very High Very High
agonist 13 99.92 Very High Very High Very High
opioid receptor 2 99.62 Very High Very High Very High
Dopamine 17 99.22 Very High Very High Very High
dorsal root ganglion 8 99.22 Very High Very High Very High
IPN 5 99.08 Very High Very High Very High
tetrodotoxin 5 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 43 100.00 Very High Very High Very High
Bordatella Infection 3 100.00 Very High Very High Very High
Stress 95 99.98 Very High Very High Very High
Obesity 7 99.96 Very High Very High Very High
Drug Induced Neurotoxicity 1 99.92 Very High Very High Very High
Insulin Resistance 15 99.44 Very High Very High Very High
Ganglion Cysts 13 99.22 Very High Very High Very High
Inflammatory Pain 5 99.08 Very High Very High Very High
Nociception 11 95.48 Very High Very High Very High
Injury 14 94.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Persistent nociceptive behavior in rats induced by subcutaneous formalin injection was significantly reduced by intrathecal pretreatment with a phospholipase C inhibitor (neomycin), and an inhibitor of protein kinase C (W-7), and was significantly enhanced by a phorbol ester (phorbol 12-myristate 13-acetate, PMA) and a stimulator of protein kinase C (SC-10).
Positive_regulation (enhanced) of Positive_regulation (stimulator) of kinase associated with nociception, kinase c and intrathecal
1) Confidence 0.42 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1501774 Disease Relevance 0.51 Pain Relevance 0.55
Creatine kinase and pyruvate kinase are two thiol-containing enzymes that exert a key role for cellular energy homeostasis in brain.
Positive_regulation (Creatine) of Positive_regulation (pyruvate) of kinase in brain
2) Confidence 0.42 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 19925858 Disease Relevance 0.26 Pain Relevance 0
The extent of protein kinase activation was also elevated by both acute and repeated treatment in the absence of isoproterenol.
Positive_regulation (elevated) of Positive_regulation (activation) of kinase
3) Confidence 0.26 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2937646 Disease Relevance 0 Pain Relevance 0.53
METHODS: The effects of bupivacaine on the activation of extracellular receptor-activated kinase (phosphorylation to pERK) in rat spinal cord slices, induced by presynaptic release (capsaicin), by presynaptic or postsynaptic ionotropic or metabotropic receptor activation, or by activation of intracellular protein kinase C or protein kinase A and also by a receptor-independent Ca2+ ionophore, were quantitated by immunohistochemistry, counting pERK-positive neurons in the superficial dorsal horn.
Positive_regulation (induced) of Positive_regulation (activation) of kinase in neurons
4) Confidence 0.16 Published 2006 Journal Anesthesiology Section Body Doc Link 16571978 Disease Relevance 0.09 Pain Relevance 0
METHODS: The effects of bupivacaine on the activation of extracellular receptor-activated kinase (phosphorylation to pERK) in rat spinal cord slices, induced by presynaptic release (capsaicin), by presynaptic or postsynaptic ionotropic or metabotropic receptor activation, or by activation of intracellular protein kinase C or protein kinase A and also by a receptor-independent Ca2+ ionophore, were quantitated by immunohistochemistry, counting pERK-positive neurons in the superficial dorsal horn.
Positive_regulation (induced) of Positive_regulation (activation) of kinase in neurons
5) Confidence 0.16 Published 2006 Journal Anesthesiology Section Body Doc Link 16571978 Disease Relevance 0.09 Pain Relevance 0
METHODS: The effects of bupivacaine on the activation of extracellular receptor-activated kinase (phosphorylation to pERK) in rat spinal cord slices, induced by presynaptic release (capsaicin), by presynaptic or postsynaptic ionotropic or metabotropic receptor activation, or by activation of intracellular protein kinase C or protein kinase A and also by a receptor-independent Ca2+ ionophore, were quantitated by immunohistochemistry, counting pERK-positive neurons in the superficial dorsal horn.
Positive_regulation (induced) of Positive_regulation (activation) of kinase in neurons
6) Confidence 0.16 Published 2006 Journal Anesthesiology Section Body Doc Link 16571978 Disease Relevance 0.09 Pain Relevance 0
In several cell types, the expression of the proenkephalin (PEnk) gene is enhanced after activation of protein kinase A.
Positive_regulation (enhanced) of Positive_regulation (activation) of kinase
7) Confidence 0.08 Published 1994 Journal Neurochem. Int. Section Abstract Doc Link 7820071 Disease Relevance 0 Pain Relevance 0.04
Stimulation of IL-1 receptor by IL-1beta may induce the phosphorylation of tyrosine residues in many effector proteins through the activation of p60c-src kinase.
Spec (may) Positive_regulation (induce) of Positive_regulation (activation) of kinase
8) Confidence 0.08 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622206 Disease Relevance 0.09 Pain Relevance 0.40
These results suggest that in vivo striatal DA release elicited by M1 muscarinic receptors is coupled with interaction with a Go protein and is induced by activation of protein kinase C.
Positive_regulation (induced) of Positive_regulation (activation) of kinase associated with kinase c and dopamine
9) Confidence 0.08 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 1692583 Disease Relevance 0 Pain Relevance 0.58
In vivo striatal dopamine release by M1 muscarinic receptors is induced by activation of protein kinase C.
Positive_regulation (induced) of Positive_regulation (activation) of kinase associated with kinase c and dopamine
10) Confidence 0.08 Published 1990 Journal J. Neurochem. Section Title Doc Link 1692583 Disease Relevance 0 Pain Relevance 0.56
Decorin can cause the rapid phosphorylation of EGF with the concurrent activation of mitogen-activated kinase protein kinase signal pathway.
Positive_regulation (cause) of Positive_regulation (activation) of kinase
11) Confidence 0.07 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0
These data imply that although resiniferatoxin-induced translocation of protein kinase C in dorsal root ganglion neurones was mainly indirect, it also caused direct activation of a protein kinase C-like kinase in these cells.
Positive_regulation (caused) of Positive_regulation (activation) of kinase in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion and kinase c
12) Confidence 0.07 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7643108 Disease Relevance 0.17 Pain Relevance 0.65
These results indicate that the potentiation of I(Gly) by a mu-opioid receptor agonist is partly mediated by activation of protein kinase C.
Positive_regulation (mediated) of Positive_regulation (activation) of kinase associated with kinase c, agonist and opioid receptor
13) Confidence 0.07 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11728420 Disease Relevance 0.14 Pain Relevance 0.55
A role for transcriptional repressor methyl-CpG-binding protein 2 and plasticity-related gene serum- and glucocorticoid-inducible kinase 1 in the induction of inflammatory pain states.
Positive_regulation (role) of Positive_regulation (inducible) of kinase associated with pain and ipn
14) Confidence 0.06 Published 2007 Journal J. Neurosci. Section Title Doc Link 17553988 Disease Relevance 0.55 Pain Relevance 0.91
U0126 also blocked the amphetamine-induced increases in phospho-extracellular-regulated kinase and preproenkephalin and preprodynorphin gene expression in the striatum.
Positive_regulation (amphetamine-induced) of Positive_regulation (increases) of kinase in striatum
15) Confidence 0.06 Published 2006 Journal Neuroscience Section Abstract Doc Link 16459022 Disease Relevance 0 Pain Relevance 0.11
Activation of protease-activated receptor-1 (PAR-1) produces a dual action, apamin-sensitive relaxation followed by contraction, in the rat duodenal smooth muscle, which is partially dependent on activation of L-type Ca2+ channels, protein kinase C (PKC) or tyrosine kinase (TK), and resistant to tetrodotoxin.
Spec (partially) Positive_regulation (dependent) of Spec (partially) Positive_regulation (activation) of kinase in smooth muscle associated with tetrodotoxin and kinase c
16) Confidence 0.06 Published 2000 Journal Life Sci. Section Abstract Doc Link 11065174 Disease Relevance 0 Pain Relevance 0.24
At SW 3, p-PEA-15, a FADD-ERK binding partner, was also upregulated (51%) as well as the activation of its phosphorylating Akt1 kinase (49%).
Positive_regulation (upregulated) of Positive_regulation (activation) of kinase
17) Confidence 0.06 Published 2010 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 19758790 Disease Relevance 0.06 Pain Relevance 0.75
Resiniferatoxin also caused direct activation of a Ca(2+)- and lipid-dependent kinase (or kinases) in the cytosolic fraction of dorsal root ganglia, at concentrations (100 nM to 10 microM) higher than required for displacement of [3H]resiniferatoxin binding or translocation of protein kinase C.
Positive_regulation (caused) of Positive_regulation (activation) of kinase in dorsal root ganglia associated with kinase c
18) Confidence 0.05 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7643108 Disease Relevance 0.16 Pain Relevance 0.74
We recently reported that activation of extracellular signal-regulated kinase 1/2 (ERK1/2), a member of the mitogen-activated protein kinase cascade in primary afferent neurons, was induced by noxious gastric distention in the rat, and that the activation of ERK1/2 in dorsal root ganglion (DRG) neurons can be implicated in acute visceral pain.
Positive_regulation (induced) of Positive_regulation (activation) of kinase in DRG associated with ganglion cysts, dorsal root ganglion and visceral pain
19) Confidence 0.05 Published 2010 Journal Digestion Section Abstract Doc Link 20588026 Disease Relevance 0.59 Pain Relevance 0.32
Activation of Erk in the anterior cingulate cortex during the induction and expression of chronic pain

The extracellular signal-regulated kinase (Erk) activity contributes to synaptic plasticity, a key mechanism for learning, memory and chronic pain.

Positive_regulation (contributes) of in cingulate cortex Positive_regulation (Activation) of kinase in anterior associated with lasting pain and anterior cingulate cortex
20) Confidence 0.03 Published 2008 Journal Mol Pain Section Title Doc Link PMC2503974 Disease Relevance 0.91 Pain Relevance 0.87

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