INT105330

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Context Info
Confidence 0.63
First Reported 2002
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 31
Total Number 34
Disease Relevance 13.70
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CDK2) nucleoplasm (CDK2) cytoplasm (CDK2)
cytosol (CDK2) mitosis (CDK2) nucleus (CDK2)
Anatomy Link Frequency
HT-29 2
liver 1
telomere 1
RT4 1
CDK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 52 98.72 Very High Very High Very High
Inflammation 75 98.16 Very High Very High Very High
palliative 3 79.52 Quite High
metalloproteinase 27 72.08 Quite High
cINOD 4 66.08 Quite High
Inflammatory response 13 65.04 Quite High
Spinal cord 48 57.00 Quite High
qutenza 9 50.00 Quite Low
antagonist 29 46.00 Quite Low
Opioid 68 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 136 100.00 Very High Very High Very High
Melanoma 73 100.00 Very High Very High Very High
Bullous Skin Disease 304 99.80 Very High Very High Very High
Acantholysis 65 99.12 Very High Very High Very High
Apoptosis 387 98.60 Very High Very High Very High
INFLAMMATION 92 98.16 Very High Very High Very High
Hepatocellular Cancer 132 97.76 Very High Very High Very High
Hypoxia 144 96.68 Very High Very High Very High
Cancer 598 94.60 High High
Death 104 89.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of Cdk2 protein did not change following OGF exposure (Fig. 2C).
Gene_expression (expression) of Cdk2
1) Confidence 0.63 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.64 Pain Relevance 0
The pre-treatment of cells with CQ inhibited the down-regulation of p21Cip1 and p27Kip1 expressions induced by 5-FU and, on the other hand, inhibited the up-regulation of the expression of CDK2.
Gene_expression (expression) of CDK2
2) Confidence 0.58 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0 Pain Relevance 0
Treatment of HT-29 cells with 5-FU resulted in decreased expressions of p21Cip1 and p27Kip1, and simultaneously in increased expression of CDK2.
Gene_expression (expression) of CDK2 in HT-29
3) Confidence 0.58 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0 Pain Relevance 0
To verify whether the OGF-induced downregulation of pRb was associated with changes in Cdk2, Cdk2 expression and activity levels were determined.
Spec (determined) Gene_expression (expression) of Cdk2
4) Confidence 0.54 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.66 Pain Relevance 0
p21/Cdk2 assay
Gene_expression (assay) of Cdk2
5) Confidence 0.54 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0 Pain Relevance 0
Pre-treatment of cells with CQ inhibited the down-regulation of p21Cip1 and p27Kip1 expression induced by 5-FU and, on the other hand, decreased the expression of CDK2 (Fig. 7).
Gene_expression (expression) of CDK2
6) Confidence 0.45 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0.21 Pain Relevance 0
Treatment of HT-29 cells with 5-FU alone resulted in decreased expression of p21Cip1 and p27Kip1, and simultaneously in increased expression of CDK2, as detected by Western blot.
Gene_expression (expression) of CDK2 in HT-29
7) Confidence 0.45 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0.12 Pain Relevance 0
Treatment with lovastatin or celecoxib decreased the levels of cyclin D1, CDK2, pRb and E2F1, while the combination treatment showed more pronounced suppression.
Gene_expression (levels) of CDK2
8) Confidence 0.45 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19787257 Disease Relevance 0.33 Pain Relevance 0.07
The genes that encode Cyclin E and CDK2 were both placed in the core group.
Gene_expression (encode) of CDK2
9) Confidence 0.42 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2791157 Disease Relevance 0.21 Pain Relevance 0
DCT, CDK2, BCL2, GPR143) despite having relatively higher MITF expression (Figure 1B, C), indicating that there are probably melanoma sub-types present within the broad Motif 1 and 2 classifications, and that not all cell lines with lower MITF have a Motif 1 expression profile.


Gene_expression (expression) of CDK2 associated with melanoma
10) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 0.32 Pain Relevance 0
CDK2 expression increased in HR (49%, P < 0.05) respect to control and HC groups, while no variation was detected in CDK4 in any of the tested groups (Fig. 2).
Gene_expression (expression) of CDK2 associated with hepatocellular cancer
11) Confidence 0.31 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1769509 Disease Relevance 0.28 Pain Relevance 0.04
Furthermore, we showed the abnormal expression of cyclin E and CDK2 in HR group which could be associated to the inflammatory process [16].


Gene_expression (expression) of CDK2 associated with inflammation
12) Confidence 0.31 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1769509 Disease Relevance 0.95 Pain Relevance 0.09
Hence, we analyzed the hepatic expression of cyclin E, CDK2, CDK4 and the cell cycle inhibitor p21cip1/waf1 in animals receiving continuous dietary DAB (HC) and in the HR animals.
Spec (analyzed) Gene_expression (expression) of CDK2 associated with hepatocellular cancer
13) Confidence 0.31 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1769509 Disease Relevance 0.24 Pain Relevance 0.05
Expression of AR-regulated cell cycle genes, such as A-, B- and D-type cyclins, cyclin-dependent kinases (CDK1, CDK2, CDK4, CDK6) and cyclin-dependent kinase inhibitors (CDKN1B, CDKN2A, CDKN2B), was generally unaffected [40], [41], [42], [43], [44], [45].
Gene_expression (Expression) of CDK2
14) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0 Pain Relevance 0
Similar results showing that SHP1 downregulation effected p27Kip1 expression and Cdk2-cyclin E complex formation have been reported [43].
Gene_expression (expression) of Cdk2
15) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.07 Pain Relevance 0
Cyclin E and CDK2 protein levels are increased after carcinogen withdrawal
Gene_expression (levels) of CDK2 associated with withdrawal
16) Confidence 0.26 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1769509 Disease Relevance 0.14 Pain Relevance 0.05
Left branch shows distinctive underexpression and loss of expression areas with genes such as IFNGR2, interleukin 2, laminin B1, MSH2, MSH6 CASP8 and 10, RB1, PCNA, EGFR and PGS2, among others, and a few overexpressed genes such as MIF, CDK 2, 5, and 7, RPSA, JUP and ITGAE.
Gene_expression (underexpression) of CDK 2
17) Confidence 0.26 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.63 Pain Relevance 0.04
Left branch shows distinctive underexpression and loss of expression areas with genes such as IFNGR2, interleukin 2, laminin B1, MSH2, MSH6 CASP8 and 10, RB1, PCNA, EGFR and PGS2, among others, and a few overexpressed genes such as MIF, CDK 2, 5, and 7, RPSA, JUP and ITGAE.
Gene_expression (overexpressed) of CDK 2
18) Confidence 0.26 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.58 Pain Relevance 0.04
Left branch shows distinctive underexpression and loss of expression areas with genes such as IFNGR2, interleukin 2, laminin B1, MSH2, MSH6 CASP8 and 10, RB1, PCNA, EGFR and PGS2, among others, and a few overexpressed genes such as MIF, CDK 2, 5, and 7, RPSA, JUP and ITGAE.
Gene_expression (expression) of CDK 2
19) Confidence 0.26 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.62 Pain Relevance 0.04
Our treatment also reduced the expression of cyclin D1, cyclin D2, p-Rb and cyclin E while the expression of Cdk2 was unaffected.
Gene_expression (expression) of Cdk2
20) Confidence 0.24 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2908539 Disease Relevance 0.25 Pain Relevance 0

General Comments

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