INT105332

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Context Info
Confidence 0.45
First Reported 2001
Last Reported 2010
Negated 5
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 8.39
Pain Relevance 2.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (IFI27) molecular_function (IFI27)
Anatomy Link Frequency
muscle cells 2
skeletal muscle 2
muscle fibers 2
lung 2
IFI27 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 37 100.00 Very High Very High Very High
dexamethasone 5 96.80 Very High Very High Very High
peptic ulcer disease 1 96.00 Very High Very High Very High
abdominal pain 1 87.88 High High
Pain 1 86.08 High High
palliative 4 80.04 Quite High
COX-2 inhibitor 1 66.76 Quite High
diclofenac 1 65.08 Quite High
acular 2 64.04 Quite High
Inflammation 5 50.00 Quite Low
Disease Link Frequency Relevance Heat
Gastritis 3 99.92 Very High Very High Very High
Mesothelioma 33 99.64 Very High Very High Very High
Apoptosis 43 99.12 Very High Very High Very High
Prostate Cancer 9 98.80 Very High Very High Very High
Cancer 206 98.32 Very High Very High Very High
Reprotox - General 1 9 96.52 Very High Very High Very High
Ulcers 1 96.00 Very High Very High Very High
Disease 25 95.48 Very High Very High Very High
Stomach Cancer 1 95.00 High High
Malignant Neoplastic Disease 9 94.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Darbufelone inhibited the proliferation of non-small cell lung cancer cell lines in a dose-dependent manner, and induced cell cycle arrest at G0/G1 phase through up-regulation of p27 expression.
Regulation (regulation) of Gene_expression (expression) of p27 in lung
1) Confidence 0.45 Published 2010 Journal Cancer Chemother. Pharmacol. Section Body Doc Link 20352217 Disease Relevance 0.16 Pain Relevance 0
In the present study we could not find any relation between p27 and cyclin D1 expression.
Regulation (relation) of Gene_expression (expression) of p27
2) Confidence 0.42 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208869 Disease Relevance 0.69 Pain Relevance 0
In a few reports, p27 and p21 staining did not correlate significantly with any clinicopathologic parameters [28,29], but there was an association between p27 and cyclin D1 expression indicating that the balance between the two opposing regulators was important for the end result of cell cycle progression [22].
Regulation (association) of Gene_expression (expression) of p27
3) Confidence 0.42 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208869 Disease Relevance 0.92 Pain Relevance 0
On the other hand, there was no association between p27 expression and other clinicopathologic parameters.
Neg (no) Regulation (association) of Gene_expression (expression) of p27
4) Confidence 0.42 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208869 Disease Relevance 0.65 Pain Relevance 0
These samples were utilized to determine p27 expression in other tissues, for comparison with expression in the skeletal muscle (Fig. 9).
Spec (determine) Regulation (determine) of Spec (determine) Gene_expression (expression) of p27 in skeletal muscle
5) Confidence 0.42 Published 2001 Journal BMC Clin Pathol Section Body Doc Link PMC59662 Disease Relevance 0.30 Pain Relevance 0
Immunoblotting and in vitro ubiquitination assays indicated that the expression of Cul1 and Skp2 and ubiquitination activity toward p27(Kip1) were not regulated by NSAIDs.
Neg (not) Regulation (regulated) of Gene_expression (expression) of p27 associated with cinod
6) Confidence 0.42 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12435820 Disease Relevance 0.26 Pain Relevance 0.63
The expression of p27 did not depend on that of other markers, the sizes of a tumor, its histological type, and affinity to this or that risk group.
Neg (not) Regulation (depend) of Gene_expression (expression) of p27 associated with cancer
7) Confidence 0.38 Published 2007 Journal Arkh. Patol. Section Abstract Doc Link 18074815 Disease Relevance 0.79 Pain Relevance 0.09
Fangchinoline induced G1/S arrest by modulating expression of p27, PCNA, and cyclin D in human prostate carcinoma cancer PC3 cells and tumor xenograft.
Regulation (modulating) of Gene_expression (expression) of p27 associated with cancer and prostate cancer
8) Confidence 0.30 Published 2010 Journal Biosci. Biotechnol. Biochem. Section Title Doc Link 20208355 Disease Relevance 1.24 Pain Relevance 0.09
To determine a character of muscle fibers (type II or type I) exhibiting changes in p27 expression, adjacent cryostat sections were stained for actomyosin adenosinetriphosphatase (ATPase).
Regulation (changes) of Gene_expression (expression) of p27 in muscle fibers
9) Confidence 0.25 Published 2001 Journal BMC Clin Pathol Section Body Doc Link PMC59662 Disease Relevance 0.09 Pain Relevance 0
These observations indicate that changes in p27 expression can determine the fate of muscle cells.
Regulation (changes) of Gene_expression (expression) of p27 in muscle cells
10) Confidence 0.25 Published 2001 Journal BMC Clin Pathol Section Body Doc Link PMC59662 Disease Relevance 0.51 Pain Relevance 0
Furthermore, the replenishment of PGE1, PGE2 or PGF2alpha did not reverse the effects of AIDs on proliferation and expressions of p27(kip1) and cyclin D2 in hOBs.
Neg (not) Regulation (effects) of Gene_expression (expressions) of p27 associated with cinod
11) Confidence 0.25 Published 2009 Journal Toxicology Section Abstract Doc Link 19428934 Disease Relevance 0.85 Pain Relevance 1.04
The expression of several cell cycle (p21, p27, cyclin D1) and apoptotic (survivin, Bcl-xL) regulatory proteins was altered after U0126 and/or sulindac treatment.
Regulation (altered) of Gene_expression (expression) of p27
12) Confidence 0.23 Published 2003 Journal Pancreas Section Body Doc Link 14576498 Disease Relevance 0.13 Pain Relevance 0
Helicobacter pylori releases a factor(s) inhibiting cell cycle progression of human gastric cell lines by affecting cyclin E/cdk2 kinase activity and Rb protein phosphorylation through enhanced p27(KIP1) protein expression.
Regulation (affecting) of Gene_expression (expression) of p27 associated with gastritis
13) Confidence 0.16 Published 2002 Journal Exp. Cell Res. Section Title Doc Link 12441136 Disease Relevance 0.71 Pain Relevance 0.10
No appreciable changes were observed in the levels of Cyc A and p27 in both mesothelioma cell lines with all the different drug treatments (data not shown).


Neg (No) Regulation (changes) of Gene_expression (levels) of p27 associated with mesothelioma
14) Confidence 0.06 Published 2008 Journal J Transl Med Section Body Doc Link PMC2412853 Disease Relevance 0.44 Pain Relevance 0
Androgenic hormones regulate the expression of key cell cycle regulators, cyclin-dependent kinase 2 and 4, and that of the cell cycle inhibitor p27.
Regulation (regulate) of Gene_expression (expression) of p27
15) Confidence 0.01 Published 2002 Journal Endocr. Relat. Cancer Section Abstract Doc Link 12237244 Disease Relevance 0.65 Pain Relevance 0.08

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