INT105336

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Context Info
Confidence 0.56
First Reported 2002
Last Reported 2010
Negated 10
Speculated 2
Reported most in Body
Documents 52
Total Number 54
Disease Relevance 32.53
Pain Relevance 4.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (AKT1) nucleoplasm (AKT1) transport (AKT1)
small molecule metabolic process (AKT1) enzyme binding (AKT1) carbohydrate metabolic process (AKT1)
Anatomy Link Frequency
SiHa 1
leukocyte 1
epithelial cells 1
A549 1
keratinocyte 1
AKT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 75 100.00 Very High Very High Very High
Nicotine 82 99.84 Very High Very High Very High
diclofenac 11 99.08 Very High Very High Very High
cytokine 66 98.48 Very High Very High Very High
cINOD 79 98.44 Very High Very High Very High
opioid receptor 4 98.32 Very High Very High Very High
antagonist 59 97.56 Very High Very High Very High
agonist 37 95.32 Very High Very High Very High
chemokine 25 94.96 High High
endometriosis 7 94.00 High High
Disease Link Frequency Relevance Heat
Apoptosis 845 99.96 Very High Very High Very High
Adhesions 57 99.96 Very High Very High Very High
Leukemia 27 99.96 Very High Very High Very High
Carcinoma 225 99.84 Very High Very High Very High
Cancer 1394 99.68 Very High Very High Very High
Recurrence 39 99.58 Very High Very High Very High
Skin Cancer 82 99.50 Very High Very High Very High
Stomach Cancer 11 99.08 Very High Very High Very High
Small Cell Lung Cancer 8 99.00 Very High Very High Very High
Capsule Opacification 102 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Being a key pro-survival factor, Akt is often deregulated during tumorigenesis [19].
Regulation (deregulated) of Akt
1) Confidence 0.56 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.37 Pain Relevance 0
Valproic acid and butyrate do not affect the Akt activity and cellular survival of SiHa cells
Regulation (affect) of Akt in SiHa
2) Confidence 0.56 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.75 Pain Relevance 0
The effects of estrogen on distinct intracellular signaling pathways including MAPK, PI3K/AKT and NF-kappa B may take a role in enhanced endometrial cell survival, altered immune response, and differential cytokine and chemokine expression in endometriosis.
Regulation (effects) of AKT associated with endometriosis, chemokine and cytokine
3) Confidence 0.44 Published 2009 Journal Front Biosci (Elite Ed) Section Abstract Doc Link 19482657 Disease Relevance 1.06 Pain Relevance 0.50
The cancer recurrence exhibited strong up-regulation of transcripts from genes in both the MAPK/ERK and PI3K/AKT pathways (Figure 2b).
Regulation (regulation) of AKT associated with cancer and recurrence
4) Confidence 0.44 Published 2010 Journal Genome Biol Section Body Doc Link PMC2945784 Disease Relevance 1.62 Pain Relevance 0
These changes mitigate the effect of PTEN loss on the PI3K/AKT pathway and suggest that the loss of PTEN serves primarily to further activate the RET pathway to drive tumor growth.
Regulation (effect) of AKT associated with cancer
5) Confidence 0.44 Published 2010 Journal Genome Biol Section Body Doc Link PMC2945784 Disease Relevance 0.86 Pain Relevance 0
Taken together, these data suggest that the mechanisms of resistance to the RET targeting selective kinase inhibitors sunitinib and sorafenib are the up-regulation of the targeted MAPK/ERK pathway and the parallel PI3K/AKT pathway.
Regulation (regulation) of AKT
6) Confidence 0.44 Published 2010 Journal Genome Biol Section Body Doc Link PMC2945784 Disease Relevance 1.27 Pain Relevance 0
We, for the first time, show that the down-regulation of Akt activity is a consequence of inhibition of Akt1 and Akt2 expression by valproic acid and butyrate.
Regulation (regulation) of Akt
7) Confidence 0.41 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.62 Pain Relevance 0
Molecular mechanism of diclofenac-induced apoptosis of promyelocytic leukemia: dependency on reactive oxygen species, Akt, Bid, cytochrome and caspase pathway.
Regulation (dependency) of Akt associated with leukemia, apoptosis and diclofenac
8) Confidence 0.41 Published 2004 Journal Free Radic. Biol. Med. Section Title Doc Link 15451068 Disease Relevance 0.62 Pain Relevance 0.45
Our data suggest novel mechanisms of NSAIDs antiproliferative action in cancer epithelial cells, which depends on the status of negative regulation of the PKB/Akt pathway and the isoform-specific action of Akt2.
Regulation (regulation) of PKB/Akt in epithelial cells associated with cancer and cinod
9) Confidence 0.40 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19433066 Disease Relevance 0.53 Pain Relevance 0.30
The anti-EGFR agents result in down regulation of the MAPK and PI3K/AKT signaling pathways.
Regulation (regulation) of AKT
10) Confidence 0.32 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 0.81 Pain Relevance 0.05
AKT1 is regulated by ?
Regulation (regulated) of AKT1
11) Confidence 0.29 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.25 Pain Relevance 0.37
Collectively, these results indicate that activated AKT in BDC cells is associated with radioresistance and suggest that pharmacological or genetic modulation of AKT activity may have important therapeutic implications in BDC patients treated with radiation.
Regulation (modulation) of AKT associated with bile duct neoplasms
12) Confidence 0.27 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15150102 Disease Relevance 0.83 Pain Relevance 0.04
Canine squamous cell carcinomas were used as a positive control for TERT, pAkt, ?
Regulation (control) of pAkt associated with skin cancer
13) Confidence 0.27 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.17 Pain Relevance 0
A constitutively active Rac mutant (L61Rac) rescued alpha(V)beta(3)-dependent spreading in the presence of NS398 or, but did not accelerate adhesion, whereas a dominant negative Rac mutant (N17Rac) suppressed spreading without affecting adhesion. alpha(5)beta(1)-mediated HUVEC adhesion, Rac activation, and spreading were not affected by PGE(2), 8-brcAMP, or the inhibition of PKA.
Neg (not) Regulation (affected) of Rac associated with adhesions
14) Confidence 0.26 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12237321 Disease Relevance 0.90 Pain Relevance 0.11
Leukocyte signaling: Signaling molecules, receptors, and adaptors important for regulation of leukocyte activation beyond major signaling pathways (i.e., MAPK, PI3K/Akt, NF-?
Regulation (regulation) of Akt in leukocyte
15) Confidence 0.26 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2001184 Disease Relevance 0.08 Pain Relevance 0.27
Together, these results show that naltrindole is a new inhibitor of the Akt/PKB signaling pathway, suggesting that naltrindole could be a potential lead for the development of a new type of inhibitors that target the constitutively active Akt/PKB signaling-dependent SCLC cells.
Regulation (target) of Akt associated with small cell lung cancer
16) Confidence 0.26 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15574783 Disease Relevance 0.62 Pain Relevance 0.08
In this study, we investigated the effects of sulindac and its metabolite, sulindac sulfide on modulation of the critical survival kinase, protein kinase B (PKB).
Regulation (modulation) of PKB
17) Confidence 0.25 Published 2006 Journal Int. J. Oncol. Section Abstract Doc Link 16685448 Disease Relevance 0.29 Pain Relevance 0.09
Furthermore, activities of known GEFs and GAPs affecting RAC could be assessed to determine potential causes of the increased RAC activity.
Regulation (affecting) of RAC
18) Confidence 0.23 Published 2008 Journal Eplasty Section Body Doc Link PMC2311454 Disease Relevance 0.39 Pain Relevance 0
The expression levels of both MAPK and Akt remained unchanged by nicotine in all treatment groups.
Neg (unchanged) Regulation (unchanged) of Akt associated with nicotine
19) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737633 Disease Relevance 1.12 Pain Relevance 0.43
One of the downstream targets of Akt is the serine/threonine kinase mTOR which is a promising candidate target in the PI3K/Akt pathway in HCC [43].
Regulation (pathway) of Akt associated with carcinoma
20) Confidence 0.22 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.07 Pain Relevance 0

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