INT105338

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Context Info
Confidence 0.04
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.93
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Prkaca, AKT1) plasma membrane (Prkaca, AKT1) cytoplasm (Prkaca, AKT1)
kinase activity (Prkaca, AKT1) cell differentiation (AKT1) nucleoplasm (AKT1)
Anatomy Link Frequency
endothelial cell 1
Prkaca (Mus musculus)
AKT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1 93.96 High High
COX-2 inhibitor 1 72.16 Quite High
agonist 1 55.36 Quite High
cINOD 1 34.44 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 11 97.98 Very High Very High Very High
Cancer 1 94.88 High High
INFLAMMATION 2 93.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, these results demonstrate that PGE(2) accelerates alpha(V)beta(3)-mediated endothelial cell adhesion through cAMP-dependent PKA activation and induces alpha(V)beta(3)-dependent spreading via cAMP- and PKA-dependent Rac activation and may contribute to the further understanding of the regulation of vascular integrins alpha(V)beta(3) by COX-2/PGE(2) during tumor angiogenesis and inflammation.
PKA-dependent Positive_regulation (activation) of Rac in endothelial cell associated with inflammation, cancer and adhesions
1) Confidence 0.04 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12237321 Disease Relevance 0.93 Pain Relevance 0.11

General Comments

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