INT105342

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Context Info
Confidence 0.46
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.83
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gck) nucleoplasm (Gck) mitochondrion (Gck)
nucleus (Gck) carbohydrate metabolic process (Gck) kinase activity (Gck)
Anatomy Link Frequency
blood 2
melanocyte 2
Gck (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid 5 100.00 Very High Very High Very High
Cannabinoid receptor 3 99.98 Very High Very High Very High
agonist 1 78.96 Quite High
cannabis 1 74.68 Quite High
Analgesic 1 25.00 Low Low
Intracerebroventricular 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Clonidine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperglycemia 2 98.12 Very High Very High Very High
Obesity 29 97.76 Very High Very High Very High
Hyperinsulinism 13 96.46 Very High Very High Very High
Insulin Resistance 3 88.04 High High
Congenital Anomalies 4 60.92 Quite High
Osteoporosis 7 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 3 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low
Diabetes Mellitus 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genes affected similarly by Delta(9)-THC and R(+)-WIN 55,212-2 were considered likely to reflect cannabinoid receptor activation, and expression of the protein products of two such genes not previously implicated in cannabinoid signaling-melanocyte-specific gene-related gene 1 (MRG1) and hexokinase 4 (glucokinase, GK)-was measured by Western blotting and immunohistochemistry.
Positive_regulation (activation) of Gene_expression (expression) of glucokinase in melanocyte associated with cannabinoid receptor and cannabinoid
1) Confidence 0.46 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12237329 Disease Relevance 0 Pain Relevance 0.36
-cell proliferation in the adipocyte-deficient mice, the data presented here show that hyperinsulinemia and lower blood glucose levels precede the appearance of obesity and hyperglycemia in ob/ob and adipocyte-deficient mice, respectively, and can be ascribed in both cases to an increase in Insulin and Glucokinase expression and, to a lesser extent, to an increase in ?
Positive_regulation (increase) of Gene_expression (expression) of Glucokinase in blood associated with hyperglycemia, obesity and hyperinsulinism
2) Confidence 0.36 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.83 Pain Relevance 0

General Comments

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