INT105344

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Context Info
Confidence 0.78
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.65
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Cited2) nucleus (Cited2) cytoplasm (Cited2)
Anatomy Link Frequency
melanocyte 2
epithelium 1
Cited2 (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid 10 100.00 Very High Very High Very High
Cannabinoid receptor 6 99.66 Very High Very High Very High
agonist 3 78.32 Quite High
cannabis 2 74.04 Quite High
Pain 3 55.52 Quite High
Analgesic 2 25.00 Low Low
medulla 5 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 18 98.76 Very High Very High Very High
Metastasis 20 98.36 Very High Very High Very High
Osteolysis 4 97.32 Very High Very High Very High
Convulsion 4 86.20 High High
Congenital Anomalies 23 84.56 Quite High
Heart Defects 3 77.52 Quite High
Craniofacial Abnormalities 2 75.48 Quite High
Cancer 3 74.72 Quite High
Syndrome 70 73.28 Quite High
Hypercalcemia 2 58.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, reducing CITED2 expression in NT2.5 cells inhibited the establishment of bone metastasis and osteolysis in vivo, suggesting a potential role for CITED2 in promoting breast cancer bone metastasis.
Gene_expression (expression) of CITED2 associated with breast cancer, osteolysis and metastasis
1) Confidence 0.78 Published 2010 Journal Int. J. Cancer Section Abstract Doc Link 19642106 Disease Relevance 1.59 Pain Relevance 0
In further studies, we found that expression of CITED2 was elevated in human primary breast tumors and bone metastasis compared to normal mammary epithelium and was highest in breast cancer cell lines that cause osteolytic bone metastasis in animal models.
Gene_expression (expression) of CITED2 in epithelium associated with breast cancer and metastasis
2) Confidence 0.78 Published 2010 Journal Int. J. Cancer Section Abstract Doc Link 19642106 Disease Relevance 1.59 Pain Relevance 0.06
Genes affected similarly by Delta(9)-THC and R(+)-WIN 55,212-2 were considered likely to reflect cannabinoid receptor activation, and expression of the protein products of two such genes not previously implicated in cannabinoid signaling-melanocyte-specific gene-related gene 1 (MRG1) and hexokinase 4 (glucokinase, GK)-was measured by Western blotting and immunohistochemistry.
Gene_expression (expression) of MRG1 in melanocyte associated with cannabinoid receptor and cannabinoid
3) Confidence 0.75 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12237329 Disease Relevance 0 Pain Relevance 0.35
Genes affected similarly by Delta(9)-THC and R(+)-WIN 55,212-2 were considered likely to reflect cannabinoid receptor activation, and expression of the protein products of two such genes not previously implicated in cannabinoid signaling-melanocyte-specific gene-related gene 1 (MRG1) and hexokinase 4 (glucokinase, GK)-was measured by Western blotting and immunohistochemistry.
Gene_expression (expression) of cannabinoid signaling-melanocyte-specific gene-related gene 1 in melanocyte associated with cannabinoid receptor and cannabinoid
4) Confidence 0.51 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12237329 Disease Relevance 0 Pain Relevance 0.35
Satb2, Pitx2, Trps1, Tcof1, Cited2), expression changes in the same genes in Nipbl+/?
Gene_expression (expression) of Cited2
5) Confidence 0.44 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.47 Pain Relevance 0

General Comments

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