INT105346

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Context Info
Confidence 0.71
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 3.05
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gck) nucleoplasm (Gck) mitochondrion (Gck)
nucleus (Gck) carbohydrate metabolic process (Gck) kinase activity (Gck)
Anatomy Link Frequency
melanocyte 3
blood 1
adipocyte 1
Gck (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid 15 100.00 Very High Very High Very High
Cannabinoid receptor 9 99.66 Very High Very High Very High
tolerance 23 83.84 Quite High
agonist 3 78.32 Quite High
imagery 16 74.44 Quite High
cannabis 3 74.04 Quite High
Analgesic 3 25.00 Low Low
Intracerebroventricular 16 5.00 Very Low Very Low Very Low
Clonidine 8 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 118 99.92 Very High Very High Very High
Hyperglycemia 10 97.64 Very High Very High Very High
Hyperinsulinism 52 97.24 Very High Very High Very High
Congenital Anomalies 16 89.40 High High
Insulin Resistance 33 87.08 High High
Impaired Glucose Tolerance 22 84.48 Quite High
Body Weight 12 72.04 Quite High
Stress 3 50.00 Quite Low
Osteoporosis 28 38.04 Quite Low
Diabetes Mellitus 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genes affected similarly by Delta(9)-THC and R(+)-WIN 55,212-2 were considered likely to reflect cannabinoid receptor activation, and expression of the protein products of two such genes not previously implicated in cannabinoid signaling-melanocyte-specific gene-related gene 1 (MRG1) and hexokinase 4 (glucokinase, GK)-was measured by Western blotting and immunohistochemistry.
Gene_expression (expression) of glucokinase in melanocyte associated with cannabinoid receptor and cannabinoid
1) Confidence 0.71 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12237329 Disease Relevance 0 Pain Relevance 0.35
In addition, expression of Insulin and Glucokinase in isolated islets (Fig. 3 H) was induced by osteocalcin in a time- and dose-dependent manner.
Gene_expression (expression) of Glucokinase
2) Confidence 0.56 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.41 Pain Relevance 0.04
Expression of Insulin, Glucokinase, and Cdk4 was up-regulated to the same extent in islets of adipocyte-deficient and ob/ob mice (Fig. 1 H), and insulin content was significantly increased in islets of adipocyte-deficient mice (Fig.
Gene_expression (Expression) of Glucokinase in adipocyte associated with obesity
3) Confidence 0.56 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.72 Pain Relevance 0
Expression of the Insulin genes and of Glucokinase, a central component of the glucose-sensing machinery of ?
Gene_expression (Expression) of Glucokinase
4) Confidence 0.56 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.90 Pain Relevance 0
-cell proliferation in the adipocyte-deficient mice, the data presented here show that hyperinsulinemia and lower blood glucose levels precede the appearance of obesity and hyperglycemia in ob/ob and adipocyte-deficient mice, respectively, and can be ascribed in both cases to an increase in Insulin and Glucokinase expression and, to a lesser extent, to an increase in ?
Gene_expression (expression) of Glucokinase in blood associated with hyperglycemia, obesity and hyperinsulinism
5) Confidence 0.49 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.83 Pain Relevance 0
Genes affected similarly by Delta(9)-THC and R(+)-WIN 55,212-2 were considered likely to reflect cannabinoid receptor activation, and expression of the protein products of two such genes not previously implicated in cannabinoid signaling-melanocyte-specific gene-related gene 1 (MRG1) and hexokinase 4 (glucokinase, GK)-was measured by Western blotting and immunohistochemistry.
Gene_expression (expression) of GK in melanocyte associated with cannabinoid receptor and cannabinoid
6) Confidence 0.48 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12237329 Disease Relevance 0 Pain Relevance 0.35
Genes affected similarly by Delta(9)-THC and R(+)-WIN 55,212-2 were considered likely to reflect cannabinoid receptor activation, and expression of the protein products of two such genes not previously implicated in cannabinoid signaling-melanocyte-specific gene-related gene 1 (MRG1) and hexokinase 4 (glucokinase, GK)-was measured by Western blotting and immunohistochemistry.
Gene_expression (expression) of hexokinase 4 in melanocyte associated with cannabinoid receptor and cannabinoid
7) Confidence 0.48 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12237329 Disease Relevance 0 Pain Relevance 0.35
On the other hand, overexpression of SOD1 did not alter the gene expression of glucokinase, the rate-limiting enzyme of glycolysis (Fig. 3).
Gene_expression (expression) of glucokinase
8) Confidence 0.21 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.20 Pain Relevance 0.04

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