INT10535

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Context Info
Confidence 0.59
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 4.93
Pain Relevance 3.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Trib3) nucleus (Trib3) enzyme binding (Trib3)
kinase activity (Trib3)
Anatomy Link Frequency
neurons 5
brain 2
dorsal root ganglia 2
neurite 1
Trib3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 46 100.00 Very High Very High Very High
opiate 6 99.98 Very High Very High Very High
Neuropathic pain 4 98.60 Very High Very High Very High
Locus ceruleus 3 98.52 Very High Very High Very High
central sensitization 65 98.40 Very High Very High Very High
addiction 4 97.44 Very High Very High Very High
carbamazepine 18 97.28 Very High Very High Very High
Glutamate receptor 8 96.88 Very High Very High Very High
Eae 6 94.00 High High
Inflammation 14 93.68 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 10 100.00 Very High Very High Very High
Adhesions 4 100.00 Very High Very High Very High
Nociception 60 99.80 Very High Very High Very High
Injury 15 99.76 Very High Very High Very High
Anaemia 1 99.66 Very High Very High Very High
Neuropathic Pain 9 98.60 Very High Very High Very High
Disease 128 97.84 Very High Very High Very High
Opiate Addiction 3 97.44 Very High Very High Very High
Obesity 4 96.24 Very High Very High Very High
Hyponatremia 2 95.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This paper provides evidence that central sensitization and persistent nociception following formalin-induced tissue injury in rats is dependent on the production of protein kinase C.
Positive_regulation (dependent) of Gene_expression (production) of kinase associated with nociception, kinase c, central sensitization and injury
1) Confidence 0.59 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1501774 Disease Relevance 0.51 Pain Relevance 0.46
Induction of nerve injury-associated kinase expression in dorsal root ganglia in the rat neuropathic pain model was confirmed by quantitative reverse transcription-polymerase chain reaction, and RNA in situ hybridization analysis revealed enhanced levels of nerve injury-associated kinase within neurons.Together, our data implicate nerve injury-associated kinase as a novel upstream component of an intracellular signalling cascade that is up-regulated in dorsal root ganglia neurons in response to sciatic nerve injury.
Positive_regulation (Induction) of Gene_expression (expression) of kinase in dorsal root ganglia associated with nervous system injury, neuropathic pain and sciatic nerve
2) Confidence 0.40 Published 2000 Journal Neuroscience Section Abstract Doc Link 11113325 Disease Relevance 1.08 Pain Relevance 0.43
We have found that chronic opiates increase levels of the G-protein subunits Gi alpha and Go alpha, adenylate cyclase, cyclic AMP-dependent protein kinase, and a number of phosphoproteins (including tyrosine hydroxylase) in this brain region.
Positive_regulation (increase) of Gene_expression (levels) of kinase in brain associated with opiate
3) Confidence 0.35 Published 1993 Journal Neurochem. Res. Section Abstract Doc Link 8385277 Disease Relevance 0.17 Pain Relevance 0.73
The authors hypothesized that dexmedetomidine increases the expression of active (autophosphorylated) focal adhesion kinase (FAK), a nonreceptor tyrosine kinase playing a pivotal role in cellular plasticity and survival.
Positive_regulation (increases) of Gene_expression (expression) of kinase associated with adhesions
4) Confidence 0.15 Published 2005 Journal Anesthesiology Section Abstract Doc Link 16249671 Disease Relevance 0.27 Pain Relevance 0.14
The authors hypothesized that dexmedetomidine increases the expression of active (autophosphorylated) focal adhesion kinase (FAK), a nonreceptor tyrosine kinase playing a pivotal role in cellular plasticity and survival.
Positive_regulation (increases) of Gene_expression (expression) of kinase associated with adhesions
5) Confidence 0.11 Published 2005 Journal Anesthesiology Section Abstract Doc Link 16249671 Disease Relevance 0.27 Pain Relevance 0.14
This event produces a large influx of calcium into the nociceptive neurons, activating multiple intracellular protein kinase cascades, such as CaM kinase II, PKC, as well as MAP kinase [2,4,6,18,30-34].
Positive_regulation (activating) of Gene_expression (cascades) of kinase in neurons associated with nociception and kinase c
6) Confidence 0.05 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0.37 Pain Relevance 0.65
This event produces a large influx of calcium into the nociceptive neurons, activating multiple intracellular protein kinase cascades, such as CaM kinase II, PKC, as well as MAP kinase [2,4,6,18,30-34].
Positive_regulation (activating) of Gene_expression (cascades) of kinase in neurons associated with nociception and kinase c
7) Confidence 0.05 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0.37 Pain Relevance 0.64
Activities of a number of kinases can be modulated by PP2A both in vitro and in vivo, particularly the ERK/MAPKs, the calmodulin-dependent kinases, PKA PKB, PKC, p70S6 kinase, the I?
Positive_regulation (particularly) of Gene_expression (/) of kinase
8) Confidence 0.04 Published 2006 Journal Mol Pain Section Body Doc Link PMC1559591 Disease Relevance 0.24 Pain Relevance 0.12
Focused ultrasound treatment in the presence of ultrasound contrast agent, increases PI3 kinase/Akt signaling activity, while the activity of MAPK signaling pathways remains unaffected
Positive_regulation (increases) of Gene_expression (/) of kinase
9) Confidence 0.03 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0
One case of hyponatremia (123 mmol/L) occurred in a patient receiving eslicarbazepine 800 mg once daily with concomitant carbamazepine and a baseline sodium of 133 mmol/L.28 Additionally there was one case each of mild electrolyte imbalance, mild anemia, and a moderate elevation of creatine kinase.34
Positive_regulation (creatine) of Gene_expression (elevation) of kinase associated with hyponatremia, anaemia and carbamazepine
10) Confidence 0.02 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857610 Disease Relevance 0.40 Pain Relevance 0.22
We report that nabumetone decreased uninvolved intestinal mucosal beta-catenin levels in the MIN mouse with a concomitant increase in glycogen synthase kinase (GSK)-3beta levels, an enzyme that targets beta-catenin for destruction.
Positive_regulation (increase) of Gene_expression (levels) of kinase
11) Confidence 0.01 Published 2005 Journal Cancer Lett. Section Abstract Doc Link 15617833 Disease Relevance 0.26 Pain Relevance 0.12
Placement of a RARE on the proenkephalin promoter increased NUDR-dependent activation to 41-fold, but this RARE-dependent increase was not transferable to a thymidine kinase promoter.
Neg (not) Positive_regulation (transferable) of Neg (not) Gene_expression (transferable) of kinase
12) Confidence 0.01 Published 1998 Journal Mol. Endocrinol. Section Abstract Doc Link 9773984 Disease Relevance 0.21 Pain Relevance 0
Cdk5, a member of the cyclin-dependent kinase family not linked to cell cycle, is highly expressed in neurons and, together with its regulatory protein p35, is required for neurite outgrowth.
Positive_regulation (required) of in neurite Gene_expression (expressed) of kinase in neurons
13) Confidence 0.00 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.78 Pain Relevance 0.09

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