INT10536

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Context Info
Confidence 0.66
First Reported 1987
Last Reported 2010
Negated 2
Speculated 3
Reported most in Abstract
Documents 67
Total Number 70
Disease Relevance 27.08
Pain Relevance 21.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Trib3) nucleus (Trib3) enzyme binding (Trib3)
kinase activity (Trib3)
Anatomy Link Frequency
neurons 7
medulla 4
pons 3
male germ cell 3
retina 2
Trib3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 123 100.00 Very High Very High Very High
Inflammation 109 100.00 Very High Very High Very High
cytokine 98 100.00 Very High Very High Very High
antagonist 53 100.00 Very High Very High Very High
withdrawal 47 100.00 Very High Very High Very High
opioid receptor 33 100.00 Very High Very High Very High
narcan 24 100.00 Very High Very High Very High
Hyperalgesia 18 100.00 Very High Very High Very High
Kinase C inhibitor 10 100.00 Very High Very High Very High
nociceptor 12 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 126 100.00 Very High Very High Very High
Stress 104 100.00 Very High Very High Very High
Hyperalgesia 23 100.00 Very High Very High Very High
Opiate Addiction 10 100.00 Very High Very High Very High
Adhesions 9 100.00 Very High Very High Very High
Herpes Simplex Virus 2 100.00 Very High Very High Very High
Lymphatic System Cancer 6 99.98 Very High Very High Very High
Cold Sores 6 99.92 Very High Very High Very High
Temporomandibular Joint Syndrome 4 99.82 Very High Very High Very High
Nervous System Injury 23 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This paper provides evidence that central sensitization and persistent nociception following formalin-induced tissue injury in rats is dependent on the production of protein kinase C.
Gene_expression (production) of kinase associated with nociception, kinase c, central sensitization and injury
1) Confidence 0.66 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1501774 Disease Relevance 0.51 Pain Relevance 0.46
Induction of nerve injury-associated kinase expression in dorsal root ganglia in the rat neuropathic pain model was confirmed by quantitative reverse transcription-polymerase chain reaction, and RNA in situ hybridization analysis revealed enhanced levels of nerve injury-associated kinase within neurons.Together, our data implicate nerve injury-associated kinase as a novel upstream component of an intracellular signalling cascade that is up-regulated in dorsal root ganglia neurons in response to sciatic nerve injury.
Gene_expression (expression) of kinase in dorsal root ganglia associated with nervous system injury, neuropathic pain and sciatic nerve
2) Confidence 0.52 Published 2000 Journal Neuroscience Section Abstract Doc Link 11113325 Disease Relevance 1.07 Pain Relevance 0.42
We have found that chronic opiates increase levels of the G-protein subunits Gi alpha and Go alpha, adenylate cyclase, cyclic AMP-dependent protein kinase, and a number of phosphoproteins (including tyrosine hydroxylase) in this brain region.
Gene_expression (levels) of kinase in brain associated with opiate
3) Confidence 0.40 Published 1993 Journal Neurochem. Res. Section Abstract Doc Link 8385277 Disease Relevance 0.17 Pain Relevance 0.73
These observations suggest that p38alpha kinase inhibition may be an effective therapeutic strategy to manage orthopaedic-related pain.
Neg (inhibition) Gene_expression (inhibition) of kinase associated with pain
4) Confidence 0.24 Published 2009 Journal Pain Section Abstract Doc Link 19167815 Disease Relevance 0.73 Pain Relevance 0.86
Effects of a cAMP-dependent protein kinase and protein kinase C inhibitor, H-7 (1-(5-isoquinolinesulfonyl)-2-methylpiperazine) and a cAMP- and cGMP-dependent protein kinase inhibitor, H-8 (N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide), on the behavioral signs of naloxone (an opioid receptor antagonist)-precipitated withdrawal syndrome and effects of H-7 on the change of protein kinase C activity in the pons/medulla region induced by morphine (a mu-opioid receptor agonist) or butorphanol (a mu/delta/kappa mixed opioid receptor agonist) were investigated in this study.
Gene_expression (Effects) of kinase in pons associated with narcan, opioid receptor, morphine, kinase c inhibitor, medulla, kinase c, antagonist, butorphanol, agonist and withdrawal
5) Confidence 0.23 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8549612 Disease Relevance 0.16 Pain Relevance 0.81
Possible involvement of protein kinases in physical dependence on opioids: studies using protein kinase inhibitors, H-7 and H-8.
Gene_expression (using) of kinase associated with physical dependence, narcan and opioid
6) Confidence 0.23 Published 1995 Journal Eur. J. Pharmacol. Section Title Doc Link 8549612 Disease Relevance 0.25 Pain Relevance 1.29
Effects of a cAMP-dependent protein kinase and protein kinase C inhibitor, H-7 (1-(5-isoquinolinesulfonyl)-2-methylpiperazine) and a cAMP- and cGMP-dependent protein kinase inhibitor, H-8 (N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide), on the behavioral signs of naloxone (an opioid receptor antagonist)-precipitated withdrawal syndrome and effects of H-7 on the change of protein kinase C activity in the pons/medulla region induced by morphine (a mu-opioid receptor agonist) or butorphanol (a mu/delta/kappa mixed opioid receptor agonist) were investigated in this study.
Gene_expression (Effects) of kinase in pons associated with narcan, opioid receptor, morphine, kinase c inhibitor, medulla, kinase c, antagonist, butorphanol, agonist and withdrawal
7) Confidence 0.23 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8549612 Disease Relevance 0.23 Pain Relevance 1.17
Effects of a cAMP-dependent protein kinase and protein kinase C inhibitor, H-7 (1-(5-isoquinolinesulfonyl)-2-methylpiperazine) and a cAMP- and cGMP-dependent protein kinase inhibitor, H-8 (N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide), on the behavioral signs of naloxone (an opioid receptor antagonist)-precipitated withdrawal syndrome and effects of H-7 on the change of protein kinase C activity in the pons/medulla region induced by morphine (a mu-opioid receptor agonist) or butorphanol (a mu/delta/kappa mixed opioid receptor agonist) were investigated in this study.
Gene_expression (Effects) of kinase in pons associated with narcan, opioid receptor, morphine, kinase c inhibitor, medulla, kinase c, antagonist, butorphanol, agonist and withdrawal
8) Confidence 0.23 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8549612 Disease Relevance 0.16 Pain Relevance 0.87
Interstitial cells of Cajal express c-kit receptor tyrosine kinase and are deficient in Ws/Ws mutant rats with a small deletion of the c-kit gene.
Gene_expression (express) of kinase in Interstitial cells
9) Confidence 0.19 Published 1998 Journal Pathol. Int. Section Abstract Doc Link 9832052 Disease Relevance 0.16 Pain Relevance 0.18
AIMS: To elucidate the neuronal mechanisms underlying chronic pain of the temporomandibular joint (TMJ), expression of phosphorylated extracellular signal-regulated kinase (pERK) in the trigeminal spinal nucleus caudalis (Vc) was studied in rats with a chronically inflamed TMJ.
Gene_expression (expression) of kinase in neuronal associated with snapping jaw and lasting pain
10) Confidence 0.19 Published 2007 Journal J Orofac Pain Section Abstract Doc Link 17717961 Disease Relevance 0.54 Pain Relevance 0.51
The authors hypothesized that dexmedetomidine increases the expression of active (autophosphorylated) focal adhesion kinase (FAK), a nonreceptor tyrosine kinase playing a pivotal role in cellular plasticity and survival.
Gene_expression (expression) of kinase associated with adhesions
11) Confidence 0.17 Published 2005 Journal Anesthesiology Section Abstract Doc Link 16249671 Disease Relevance 0.27 Pain Relevance 0.14
The authors hypothesized that dexmedetomidine increases the expression of active (autophosphorylated) focal adhesion kinase (FAK), a nonreceptor tyrosine kinase playing a pivotal role in cellular plasticity and survival.
Gene_expression (expression) of kinase associated with adhesions
12) Confidence 0.17 Published 2005 Journal Anesthesiology Section Abstract Doc Link 16249671 Disease Relevance 0.27 Pain Relevance 0.14
We studied the effect of electrical stimulation and a sodium channel blocker (tetrodotoxin) on the expression of muscle-specific isozymes of creatine kinase, glycogen phosphorylase, phosphoglycerate mutase, and lactate dehydrogenase in aneurally cultured embryonic rat muscle.
Gene_expression (expression) of kinase in muscle associated with tetrodotoxin and sodium channel
13) Confidence 0.12 Published 1987 Journal Exp. Neurol. Section Abstract Doc Link 2957228 Disease Relevance 0.07 Pain Relevance 0.22
Prostaglandin E(2) (PGE(2)) and epinephrine act directly on nociceptors to produce mechanical hyperalgesia through protein kinase A (PKA) alone or through a combination of PKA, protein kinase C epsilon (PKCepsilon), and extracellular signal-regulated kinase (ERK), respectively.
Gene_expression (produce) of kinase in nociceptors associated with kinase c, hyperalgesia and nociceptor
14) Confidence 0.10 Published 2003 Journal Neuron Section Abstract Doc Link 12925276 Disease Relevance 0.38 Pain Relevance 0.58
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase (RTK) transiently expressed in specific regions of the central and peripheral nervous systems.
Gene_expression (expressed) of kinase in peripheral nervous systems associated with lymphatic system cancer
15) Confidence 0.10 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19200234 Disease Relevance 0.63 Pain Relevance 0.19
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase (RTK) transiently expressed in specific regions of the central and peripheral nervous systems.
Gene_expression (expressed) of kinase in peripheral nervous systems associated with lymphatic system cancer
16) Confidence 0.10 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19200234 Disease Relevance 0.63 Pain Relevance 0.19
ALK (Anaplastic Lymphoma Kinase) expression in DRG neurons and its involvement in neuron-Schwann cells interaction.
Gene_expression (expression) of Kinase in neurons associated with lymphatic system cancer and nociceptor
17) Confidence 0.10 Published 2009 Journal Eur. J. Neurosci. Section Title Doc Link 19200234 Disease Relevance 0.81 Pain Relevance 0.66
Western blots confirmed expression of Lck kinase and c-Src kinase in uterine tissue.
Gene_expression (expression) of kinase in uterine
18) Confidence 0.10 Published 2009 Journal Reprod Sci Section Abstract Doc Link 19208792 Disease Relevance 0.23 Pain Relevance 0.23
down regulated the expression of serum glucocorticoid kinase (SGK), casein kinase I, extracellular signal-regulated kinase (ERK-1), male germ cell-associated kinase (MAK), and Wee tyrosine kinase.
Gene_expression (expression) of kinase in male germ cell
19) Confidence 0.10 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0.12
down regulated the expression of serum glucocorticoid kinase (SGK), casein kinase I, extracellular signal-regulated kinase (ERK-1), male germ cell-associated kinase (MAK), and Wee tyrosine kinase.
Gene_expression (expression) of kinase in male germ cell
20) Confidence 0.10 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0.13

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