INT105378

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Context Info
Confidence 0.26
First Reported 2002
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 8.82
Pain Relevance 2.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL12A) extracellular region (IL12A) cytoplasm (IL12A)
Anatomy Link Frequency
macrophage 1
immune cells 1
lung 1
IL12A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 198 100.00 Very High Very High Very High
Inflammation 158 100.00 Very High Very High Very High
Arthritis 109 99.36 Very High Very High Very High
methotrexate 11 98.80 Very High Very High Very High
psoriasis 21 95.72 Very High Very High Very High
rheumatoid arthritis 3 95.28 Very High Very High Very High
Multiple sclerosis 2 94.40 High High
cOX1 9 93.28 High High
Pain 3 90.80 High High
cINOD 5 90.44 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 167 100.00 Very High Very High Very High
Cancer 214 99.92 Very High Very High Very High
Autoimmune Disease 12 99.92 Very High Very High Very High
Asthma 316 99.80 Very High Very High Very High
Necrosis 9 99.68 Very High Very High Very High
Skin Cancer 30 99.52 Very High Very High Very High
Rheumatoid Arthritis 105 99.36 Very High Very High Very High
Adenocarcinoma 159 98.74 Very High Very High Very High
Inflammatory Bowel Disease 2 97.00 Very High Very High Very High
Psoriasis 29 95.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study investigated the effect of five days of oral indomethacin treatment (75 mg per day) on the serum concentrations of IL-6, IL-10, IL-12, and TNF-alpha induced by exercising healthy volunteers.
Spec (investigated) Regulation (effect) of IL-12
1) Confidence 0.26 Published 2002 Journal Cytokine Section Abstract Doc Link 12242082 Disease Relevance 0.36 Pain Relevance 0.44
IL12A is not a drug target.
Neg (not) Regulation (target) of IL12A
2) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.64 Pain Relevance 0.47
In this connection, we investigated the functionality of IL-12R on in vitro expanded NBEC since immunohistochemical studies disclosed IL-12R?
Spec (investigated) Regulation (functionality) of IL-12R
3) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702099 Disease Relevance 0.85 Pain Relevance 0.11
IL-12 treatment down-regulated significantly (P<0.001) mRNA of the pro-angiogenic factors CCL2, endoglin, HIF-1?
Regulation (regulated) of IL-12
4) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702099 Disease Relevance 0.80 Pain Relevance 0.05
IL-12 mediated down-regulation of the release of tumor promoting cytokines by NBEC may suggest that i) peritumoral NBEC contribute to support lung adenocarcinoma growth [38] and consequently ii) NBEC represent an additional IL-12 target.
Regulation (target) of IL-12 in lung associated with adenocarcinoma, cancer and cytokine
5) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702099 Disease Relevance 1.01 Pain Relevance 0.19
Curcumin inhibits these autoimmune diseases by regulating inflammatory cytokines such as IL-1beta, IL-6, IL-12, TNF-alpha and IFN-gamma and associated JAK-STAT, AP-1, and NF-kappaB signaling pathways in immune cells.
Regulation (regulating) of IL-12 in immune cells associated with autoimmune disease, inflammation and cytokine
6) Confidence 0.07 Published 2007 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 17569223 Disease Relevance 1.88 Pain Relevance 0.48
IL-12 modulation and asthma
Regulation (modulation) of IL-12 associated with asthma
7) Confidence 0.04 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.12 Pain Relevance 0.20
The modulation of IL-1, IL-6, IL-8, and IL-12 along with promotion of a Th1 response promotes antitumor and antiviral behaviour [154].
Regulation (modulation) of IL-12
8) Confidence 0.02 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 1.32 Pain Relevance 0.12
Modulation of cytokines (Interleukin (IL)-1 Beta, IL-4, IL-5, IL-6, IL-10, Interferon-gamma, IL-12, Tumor Necrosis Factor-alpha and Granulocyte macrophage colony-stimulating factor (GM-CSF)) in cervical cells and PBMCs upon stimulation with IncB and IncC was determined by real-time reverse-transcriptase (RT)-PCR and ELISA.
Spec (determined) Regulation (Modulation) of IL-12 in macrophage associated with necrosis, cancer and cytokine
9) Confidence 0.01 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2695819 Disease Relevance 0.85 Pain Relevance 0.09

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