INT105381

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Context Info
Confidence 0.48
First Reported 2002
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 10
Disease Relevance 1.07
Pain Relevance 7.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (NPFF)
Anatomy Link Frequency
CSF 1
central nervous system 1
parabrachial nucleus 1
NPFF (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 590 100.00 Very High Very High Very High
Central nervous system 7 99.90 Very High Very High Very High
parabrachial 7 99.82 Very High Very High Very High
antinociception 21 99.20 Very High Very High Very High
Opioid 147 98.00 Very High Very High Very High
narcan 35 97.32 Very High Very High Very High
antagonist 54 97.20 Very High Very High Very High
Analgesic 21 96.92 Very High Very High Very High
analgesia 49 95.56 Very High Very High Very High
opiate 28 94.84 High High
Disease Link Frequency Relevance Heat
Normal Pressure Hydrocephalus 1 99.44 Very High Very High Very High
Neuropathic Pain 14 95.08 Very High Very High Very High
Urological Neuroanatomy 7 92.32 High High
Pain 64 92.08 High High
Opiate Addiction 7 86.12 High High
Bordatella Infection 28 78.88 Quite High
Neuroblastoma 8 72.60 Quite High
Nociception 14 69.68 Quite High
INFLAMMATION 14 58.20 Quite High
Targeted Disruption 7 16.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The structural determinants responsible for binding of these molecules to NPFF receptors were investigated and led to the synthesis of hNPFF(1) receptor antagonists with affinities from 40 to 80 nM.
NPFF Binding (binding) of associated with antagonist
1) Confidence 0.48 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12242085 Disease Relevance 0 Pain Relevance 0.35
Reverse-phase high pressure liquid chromatography (HPLC) fractions of a human with normal pressure hydrocephalus cerebrospinal fluid (CSF), co-migrating with NPFF-related synthetic peptides, were characterized by capillary HPLC coupled on-line to nanospray ion trap tandem mass spectrometry.
NPFF Binding (co-migrating) of in CSF associated with normal pressure hydrocephalus
2) Confidence 0.36 Published 2002 Journal FEBS Lett. Section Abstract Doc Link 12482585 Disease Relevance 0.10 Pain Relevance 0.25
SH1-C7 cells are therefore a suitable model to investigate the interactions between NPFF and opioid receptors.
NPFF Binding (interactions) of associated with opioid receptor
3) Confidence 0.33 Published 2006 Journal Peptides Section Abstract Doc Link 16488058 Disease Relevance 0.07 Pain Relevance 0.62
In the future, the exact nature of interactions between DOR and NPFF will be further studied.
NPFF Binding (interactions) of associated with opioid receptor
4) Confidence 0.29 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1079869 Disease Relevance 0 Pain Relevance 0.61
One possible mechanism could involve a modulatory binding site for NPFF on DOR.
NPFF Binding (binding) of associated with opioid receptor
5) Confidence 0.26 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1079869 Disease Relevance 0 Pain Relevance 0.56
The nature of the interactions between NPFF and opioid receptors seems to be complex and the molecular mechanisms behind the observed physiological effects are not known.


NPFF Binding (interactions) of associated with opioid receptor
6) Confidence 0.25 Published 2005 Journal BMC Neurosci Section Abstract Doc Link PMC1079869 Disease Relevance 0.09 Pain Relevance 0.94
All changes observed in the different assays were in agreement with each other, although they had a bit different time-courses, and they all support the suggested direct interaction between NPFF and the DOR-ligand complex.
NPFF Binding (interaction) of associated with opioid receptor
7) Confidence 0.25 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1079869 Disease Relevance 0.06 Pain Relevance 0.88
In pontine parabrachial nucleus NPFF modulates synaptic transmission through interaction with presynaptic DOR, providing evidence for the cellular mechanisms of the analgesic action of NPFF at the supraspinal level [12].
NPFF Binding (interaction) of in parabrachial nucleus associated with analgesic and parabrachial
8) Confidence 0.22 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1079869 Disease Relevance 0.59 Pain Relevance 1.70
Our results from the time-resolved fluorescence based binding assays indicate that NPFF can modulate the binding of DOR ligands to the receptor.
NPFF Binding (binding) of associated with opioid receptor
9) Confidence 0.22 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1079869 Disease Relevance 0 Pain Relevance 0.74
Both NPFF1R and NPFF2R are expressed in the central nervous system and NPFF binds to both of them [17-20].
NPFF Binding (binds) of in central nervous system associated with central nervous system
10) Confidence 0.22 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1079869 Disease Relevance 0.16 Pain Relevance 0.83

General Comments

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