INT105387

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.77
First Reported 2001
Last Reported 2010
Negated 3
Speculated 3
Reported most in Abstract
Documents 116
Total Number 120
Disease Relevance 98.62
Pain Relevance 14.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (HIF1A) signal transduction (HIF1A) nucleolus (HIF1A)
nucleus (HIF1A) transcription factor binding (HIF1A) cytoplasm (HIF1A)
Anatomy Link Frequency
lung 6
bone marrow 4
margin 2
internal 2
endometrium 2
HIF1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 678 99.74 Very High Very High Very High
rheumatoid arthritis 1299 99.60 Very High Very High Very High
Osteoarthritis 62 99.60 Very High Very High Very High
anesthesia 17 99.50 Very High Very High Very High
Dismenorea 45 99.40 Very High Very High Very High
Kappa opioid receptor 3 99.36 Very High Very High Very High
cINOD 34 99.24 Very High Very High Very High
Morphine 7 98.94 Very High Very High Very High
chemokine 171 98.08 Very High Very High Very High
Snapping jaw 2 97.94 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 2556 100.00 Very High Very High Very High
Hypoxia 2027 100.00 Very High Very High Very High
Pancreatic Cancer 572 100.00 Very High Very High Very High
Dermal Scarring 288 100.00 Very High Very High Very High
Keloid Scars 39 100.00 Very High Very High Very High
Pituitary Cancer 16 100.00 Very High Very High Very High
Myositis 2 99.96 Very High Very High Very High
Apoptosis 318 99.92 Very High Very High Very High
Lung Cancer 31 99.88 Very High Very High Very High
Esophageal Cancer 21 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of subunits of HIF-1, HIF-1alpha, and HIF-1beta were examined by Western blot using specific antibodies.
Spec (examined) Gene_expression (Expression) of HIF-1
1) Confidence 0.77 Published 2005 Journal J Anesth Section Abstract Doc Link 16032459 Disease Relevance 0.38 Pain Relevance 0.56
Expression of subunits of HIF-1, HIF-1alpha, and HIF-1beta were examined by Western blot using specific antibodies.
Spec (examined) Gene_expression (Expression) of HIF-1alpha
2) Confidence 0.77 Published 2005 Journal J Anesth Section Abstract Doc Link 16032459 Disease Relevance 0.38 Pain Relevance 0.56
Although a large study correlating HIF-1alpha expression with prognosis is lacking in gastric cancer, the immunohistochemical expression of HIF-1alpha target genes (Glut-1, VEGF, CA9, iNOS) is associated with a poor prognosis.
Gene_expression (expression) of HIF-1alpha associated with stomach cancer
3) Confidence 0.75 Published 2005 Journal Eur. J. Cancer Section Abstract Doc Link 16290133 Disease Relevance 1.32 Pain Relevance 0.09
HIF-1alpha expression is associated with a poor prognosis and treatment response in a number of tumour sites.
Gene_expression (expression) of HIF-1alpha associated with cancer
4) Confidence 0.75 Published 2005 Journal Eur. J. Cancer Section Abstract Doc Link 16290133 Disease Relevance 1.24 Pain Relevance 0.07
Non-steroidal anti-inflammatory drugs, shown to reduce the risk of gastric cancer, can decrease HIF-1alpha expression.
Gene_expression (expression) of HIF-1alpha associated with inflammation, cinod and stomach cancer
5) Confidence 0.75 Published 2005 Journal Eur. J. Cancer Section Abstract Doc Link 16290133 Disease Relevance 1.37 Pain Relevance 0.10
Although a large study correlating HIF-1alpha expression with prognosis is lacking in gastric cancer, the immunohistochemical expression of HIF-1alpha target genes (Glut-1, VEGF, CA9, iNOS) is associated with a poor prognosis.
Gene_expression (expression) of HIF-1alpha associated with stomach cancer
6) Confidence 0.75 Published 2005 Journal Eur. J. Cancer Section Abstract Doc Link 16290133 Disease Relevance 1.35 Pain Relevance 0.10
Moreover, the endometrium with an abnormal location in patients with adenomyosis showed an increased VEGF and HIF-1alpha expression, particularly in the epithelial cells, associated to an increase of MVD, compared with the endometrium in a normal location in the same group of patients.
Gene_expression (expression) of HIF-1alpha in endometrium associated with dismenorea
7) Confidence 0.75 Published 2009 Journal Int. J. Gynecol. Pathol. Section Abstract Doc Link 19188818 Disease Relevance 1.04 Pain Relevance 0.57
Angiogenesis has been indicated to play an important role and our aim was to investigate whether vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1alpha (HIF-1alpha) expression and microvessel density (MVD) were different in women with and without adenomyosis.
Gene_expression (expression) of HIF-1alpha associated with hypoxia and dismenorea
8) Confidence 0.75 Published 2009 Journal Int. J. Gynecol. Pathol. Section Abstract Doc Link 19188818 Disease Relevance 0.97 Pain Relevance 0.47
MATERIALS AND METHODS: The immunohistochemical expression of HIF1alpha was studied in formalin-fixed paraffin-embedded tissues from 60 patients who had undergone thoracic surgery for lung cancer (n=48) or pneumothorax (n=12) under OLV general anesthesia.
Gene_expression (expression) of HIF1alpha in lung
9) Confidence 0.75 Published 2010 Journal Anticancer Res. Section Body Doc Link 20530420 Disease Relevance 0.19 Pain Relevance 0
HIF-1alpha protein was not expressed under any of our experimental conditions.
Neg (not) Gene_expression (expressed) of HIF-1alpha
10) Confidence 0.75 Published 2009 Journal Clin. Exp. Rheumatol. Section Body Doc Link 19327236 Disease Relevance 0.06 Pain Relevance 0
Effects on cellular oxygen consumption were measured amperometrically using a Clark electrode. mRNA expression of GLUT-1 and OPG was determined by RT-PCR; OPG protein secretion by ELISA and HIF-1alpha protein expression by immunoblotting.
Gene_expression (expression) of HIF-1alpha
11) Confidence 0.75 Published 2009 Journal Clin. Exp. Rheumatol. Section Body Doc Link 19327236 Disease Relevance 0.08 Pain Relevance 0
RESULTS: There was a significant, and rather unexpected, association of HIF1alpha expression with high body mass index (BMI) (p=0.01) and high body weight (p=0.01) of patients with lung carcinomas, but other anesthesia-related parameters, including analysis of arterial oxygen partial tension and anthropometric factors remained insignificant.
Gene_expression (expression) of HIF1alpha in body
12) Confidence 0.75 Published 2010 Journal Anticancer Res. Section Body Doc Link 20530420 Disease Relevance 0.17 Pain Relevance 0
BACKGROUND/AIM: A prospective study was designed to investigate the effects of anesthesia, particularly that of the one-lung ventilation procedure (OLV), on the expression of hypoxia-inducible factor 1alpha (HIF1alpha) in patients with lung carcinomas and pneumothorax.
Gene_expression (expression) of HIF1alpha in lung associated with anesthesia, lung cancer, hypoxia and pneumothorax
13) Confidence 0.75 Published 2010 Journal Anticancer Res. Section Abstract Doc Link 20530420 Disease Relevance 0.45 Pain Relevance 0.10
However, the significant link between high BMI and HIF1alpha expression noted in patients with lung carcinomas brings forward a possible connection between obesity and hypoxia-related molecular pathways.


Gene_expression (expression) of HIF1alpha in lung
14) Confidence 0.75 Published 2010 Journal Anticancer Res. Section Body Doc Link 20530420 Disease Relevance 0.12 Pain Relevance 0
One-lung ventilation and HIF1alpha expression in lung cancer and pneumothorax.
Gene_expression (expression) of HIF1alpha in lung associated with anesthesia, lung cancer and pneumothorax
15) Confidence 0.75 Published 2010 Journal Anticancer Res. Section Title Doc Link 20530420 Disease Relevance 0.29 Pain Relevance 0.20
CONCLUSION: Anesthesia and OLV procedure performed for lung cancer or pneumothorax does not affect the expression of HIF1alpha.
Gene_expression (expression) of HIF1alpha in lung
16) Confidence 0.75 Published 2010 Journal Anticancer Res. Section Body Doc Link 20530420 Disease Relevance 0.13 Pain Relevance 0
The expression of HIF-1?
Gene_expression (expression) of HIF
17) Confidence 0.75 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875861 Disease Relevance 0.66 Pain Relevance 0.13
Nondiabetic patients had higher HIF-1alpha and VEGF expressions compared with diabetic patients (P < 0.001).
Gene_expression (expressions) of HIF-1alpha associated with diabetes mellitus
18) Confidence 0.75 Published 2004 Journal Diabetes Section Abstract Doc Link 15331549 Disease Relevance 1.27 Pain Relevance 0.36
Because hypoxia-inducible factor (HIF)-1alpha is a transcriptional activator of vascular endothelial growth factor (VEGF) and is critical for initiating angiogenic responses to hypoxia, we investigated the expression of HIF-1alpha and VEGF in specimens of human heart tissue to elucidate the molecular responses to myocardial ischemia in diabetic patients during unstable angina.
Gene_expression (expression) of HIF-1alpha in heart associated with angina, coronary artery disease, diabetes mellitus, hypoxia and ischemia
19) Confidence 0.75 Published 2004 Journal Diabetes Section Abstract Doc Link 15331549 Disease Relevance 1.06 Pain Relevance 0.31
The expression of hypoxia inducible factor-1alpha (HIF-1alpha) reflects the status of tissue ischaemia.
Gene_expression (expression) of HIF-1alpha associated with hypoxia and cv unclassified under development
20) Confidence 0.75 Published 2003 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 12925145 Disease Relevance 0.44 Pain Relevance 0.27

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox