INT105389

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Context Info
Confidence 0.42
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.20
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (HIF1A) signal transduction (HIF1A) nucleolus (HIF1A)
nucleus (HIF1A) transcription factor binding (HIF1A) cytoplasm (HIF1A)
HIF1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 2 65.36 Quite High
agonist 43 50.00 Quite Low
qutenza 4 50.00 Quite Low
Chronic pancreatitis 3 30.84 Quite Low
Inflammation 32 23.20 Low Low
cytokine 11 22.16 Low Low
chemokine 3 8.32 Low Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
methotrexate 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 81 99.60 Very High Very High Very High
Apoptosis 32 98.24 Very High Very High Very High
Hypoxia 74 96.72 Very High Very High Very High
Cancer 330 94.40 High High
Breast Cancer 48 82.72 Quite High
Skin Cancer 4 77.24 Quite High
INFLAMMATION 32 65.36 Quite High
Acute-phase Reaction 1 62.48 Quite High
Solid Tumor 16 51.44 Quite High
Hematologic Neoplasms 39 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, an electrophoretic mobility shift assay (EMSA) from nuclear extracts from melanoma cells showed a decrease in constitutive activation of NF-kappaB and enhanced HIF-1alpha binding activity to hypoxia response element (HRE) in melanoma cells treated with different concentrations of capsaicin.
Negative_regulation (decrease) of HIF-1alpha Binding (activity) of
1) Confidence 0.42 Published 2002 Journal J. Cancer Res. Clin. Oncol. Section Body Doc Link 12242509 Disease Relevance 0.08 Pain Relevance 0
Interestingly, recent studies are beginning to define a role for HIF-1?
Negative_regulation (define) of HIF-1 Binding (role) of
2) Confidence 0.22 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 1.52 Pain Relevance 0
thereby preventing formation of an active HIF-1 heterodimer [147].
Negative_regulation (preventing) of HIF-1 Binding (formation) of
3) Confidence 0.19 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.86 Pain Relevance 0.03
The asparagine hydroxylase, factor inhibitor of HIF-1, and CITED4 (CBP p300-interacting transactivator 4), which interfere with co-activator binding, provide a further level of control [28,29].
Negative_regulation (inhibitor) of HIF-1 Binding (binding) of
4) Confidence 0.08 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246178 Disease Relevance 0.74 Pain Relevance 0

General Comments

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