INT105390

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Context Info
Confidence 0.49
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 27
Total Number 27
Disease Relevance 26.30
Pain Relevance 2.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (HIF1A) signal transduction (HIF1A) nucleolus (HIF1A)
nucleus (HIF1A) transcription factor binding (HIF1A) cytoplasm (HIF1A)
Anatomy Link Frequency
bone marrow 6
endometrium 4
skin 3
endothelial cell 2
lung 1
HIF1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 14 99.78 Very High Very High Very High
Inflammation 214 99.74 Very High Very High Very High
rheumatoid arthritis 377 97.20 Very High Very High Very High
palliative 11 94.00 High High
Arthritis 104 93.04 High High
antagonist 35 79.12 Quite High
spinal inflammation 1 62.56 Quite High
Central nervous system 16 61.08 Quite High
analgesia 7 58.96 Quite High
Pain 18 57.36 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 520 100.00 Very High Very High Very High
Myositis 1 99.96 Very High Very High Very High
Apoptosis 90 99.92 Very High Very High Very High
Cancer 935 99.86 Very High Very High Very High
Dysmenorrhea 14 99.78 Very High Very High Very High
Wound Healing 19 99.68 Very High Very High Very High
Leukemia 85 99.64 Very High Very High Very High
Systemic Sclerosis 18 99.40 Very High Very High Very High
Disease 246 98.50 Very High Very High Very High
Rheumatoid Arthritis 379 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: These data suggest that inhibition of cellular proliferation by capsaicin follows enhanced VEGF production by remaining melanoma cells by enhancing HIF-1alpha expression and binding to HRE.


Positive_regulation (enhancing) of Gene_expression (expression) of HIF-1alpha
1) Confidence 0.49 Published 2002 Journal J. Cancer Res. Clin. Oncol. Section Body Doc Link 12242509 Disease Relevance 0.06 Pain Relevance 0
HIF-1alpha overexpression may predict resistance to CRT and may be a helpful guide in choosing between therapeutic strategies, such as intensive combined modality therapy vs. palliative therapy.
Positive_regulation (overexpression) of Gene_expression (overexpression) of HIF-1 associated with palliative
2) Confidence 0.49 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 15170665 Disease Relevance 0.84 Pain Relevance 0.09
In endometrium with a normal location, instead, where VEGF increased expression seems not to be correlated with HIF-1alpha increased expression nor with an increased MVD, other mechanisms might be reasonably postulated.
Neg (nor) Positive_regulation (increased) of Gene_expression (expression) of HIF-1alpha in endometrium
3) Confidence 0.49 Published 2009 Journal Int. J. Gynecol. Pathol. Section Abstract Doc Link 19188818 Disease Relevance 0.75 Pain Relevance 0.43
Moreover, the endometrium with an abnormal location in patients with adenomyosis showed an increased VEGF and HIF-1alpha expression, particularly in the epithelial cells, associated to an increase of MVD, compared with the endometrium in a normal location in the same group of patients.
Positive_regulation (increased) of Gene_expression (expression) of HIF-1alpha in endometrium associated with dismenorea
4) Confidence 0.49 Published 2009 Journal Int. J. Gynecol. Pathol. Section Abstract Doc Link 19188818 Disease Relevance 1.05 Pain Relevance 0.58
It is reported in the literature that such interaction occurs via abrogation of the increased synthesis of HIF1a (hypoxia inducible factor-1a) induced by c-erbB2 activation by ligands (i.r. heregulin) [7].
Positive_regulation (increased) of Gene_expression (synthesis) of HIF1a associated with hypoxia
5) Confidence 0.39 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1579231 Disease Relevance 0.63 Pain Relevance 0
It is reported in the literature that such interaction occurs via abrogation of the increased synthesis of HIF1a (hypoxia inducible factor-1a) induced by c-erbB2 activation by ligands (i.r. heregulin) [7].
Positive_regulation (induced) of Gene_expression (synthesis) of HIF1a associated with hypoxia
6) Confidence 0.39 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1579231 Disease Relevance 0.64 Pain Relevance 0
Both HIF-1 production and Stat3 activity are upregulated in many types of cancer.
Positive_regulation (upregulated) of Gene_expression (production) of HIF-1 associated with cancer
7) Confidence 0.31 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 1.12 Pain Relevance 0
Compared to normal tissue controls, HIF-1 protein has been shown through immunohistochemical studies to be overexpressed in several human cancers, including colon, breast, gastric, lung, skin, ovarian, prostate, renal, and pancreatic carcinomas [40].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of HIF-1 in skin associated with cancer and pancreatic cancer
8) Confidence 0.26 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 1.00 Pain Relevance 0.03
"Angiogenesis switch" in leukemia is documented by increased bone marrow MVD, increased expression of HIF-1, multiple pro-angiogenic factors (VEGF, bFGF, angiopoietin-2), soluble VEGFR, and decreased expression of endogenous angiogenesis inhibitors, such as thrombospondin-1 [50,51].
Positive_regulation (increased) of Gene_expression (expression) of HIF-1 in bone marrow associated with leukemia
9) Confidence 0.18 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2902424 Disease Relevance 1.43 Pain Relevance 0
Over-expression of HIF-1?
Positive_regulation (Over) of Gene_expression (expression) of HIF-1
10) Confidence 0.13 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246178 Disease Relevance 0.64 Pain Relevance 0
“Angiogenesis switch” in leukemia is documented by increased bone marrow MVD (Figures 2(a) and 2(b)), increased expression of HIF-1, multiple proangiogenic factors (VEGF, bFGF, angiopoietin-2), soluble VEGFR, and decreased expression of endogenous angiogenesis inhibitors, such as thrombospondin-1 [11, 12].
Positive_regulation (increased) of Gene_expression (expression) of HIF-1 in bone marrow associated with leukemia
11) Confidence 0.11 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2875768 Disease Relevance 1.03 Pain Relevance 0
“Angiogenesis switch” in leukemia is documented by increased bone marrow MVD (Figures 2(a) and 2(b)), increased expression of HIF-1, multiple proangiogenic factors (VEGF, bFGF, angiopoietin-2), soluble VEGFR, and decreased expression of endogenous angiogenesis inhibitors, such as thrombospondin-1 [11, 12].
Positive_regulation (increased) of Gene_expression (expression) of HIF-1 in bone marrow associated with leukemia
12) Confidence 0.11 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2875768 Disease Relevance 0.97 Pain Relevance 0
Compared to normal tissue controls, HIF-1 protein has been shown through immunohistochemical studies to be overexpressed in several human cancers, including colon, breast, gastric, lung, skin, ovarian, prostate, renal, and pancreatic carcinomas [40].
Positive_regulation (overexpressed) of in lung Gene_expression (overexpressed) of HIF-1 in skin associated with cancer and pancreatic cancer
13) Confidence 0.09 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 1.00 Pain Relevance 0.03
Over-expression of HIF-1?
Positive_regulation (-) of Gene_expression (expression) of HIF-1
14) Confidence 0.09 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246178 Disease Relevance 0.64 Pain Relevance 0
Over-expression of HIF-1?
Positive_regulation (expression) of Gene_expression (expression) of HIF-1
15) Confidence 0.09 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246178 Disease Relevance 0.64 Pain Relevance 0
Therefore, ET-1-induced HIF-1 accumulation activates all the signals necessary for a complete HIF-1 response [19].
Positive_regulation (necessary) of Gene_expression (response) of HIF-1
16) Confidence 0.09 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 1.08 Pain Relevance 0.08
It should be noted that many cancer cells overexpress HIF-1?
Positive_regulation (overexpress) of Gene_expression (overexpress) of HIF-1 associated with cancer
17) Confidence 0.07 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064874 Disease Relevance 1.49 Pain Relevance 0.15
We speculate that not only does PHD2 prevent transcription of hypoxia-induced genes by hydroxylating HIF-1?
Positive_regulation (induced) of Gene_expression (hydroxylating) of HIF-1 associated with hypoxia
18) Confidence 0.06 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.51 Pain Relevance 0
VEGF is expressed in plexiform lesions and its receptor VEGFR-2 and the HIF-1 transcription complex are overexpressed [80].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of HIF-1
19) Confidence 0.06 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.63 Pain Relevance 0
A constitutively-active version of HIF-1?
Positive_regulation (version) of Gene_expression (version) of HIF-1
20) Confidence 0.06 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676804 Disease Relevance 0.27 Pain Relevance 0

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