INT105392

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Context Info
Confidence 0.45
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.83
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (HIF1A) signal transduction (HIF1A) nucleolus (HIF1A)
nucleus (HIF1A) transcription factor binding (HIF1A) cytoplasm (HIF1A)
Anatomy Link Frequency
nucleus 2
HIF1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 6 75.12 Quite High
Central nervous system 3 58.24 Quite High
agonist 43 50.00 Quite Low
qutenza 4 50.00 Quite Low
Inflammatory response 2 49.84 Quite Low
Inflammation 34 5.12 Low Low
cytokine 18 5.00 Very Low Very Low Very Low
metalloproteinase 7 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 407 99.20 Very High Very High Very High
Hypoxia 124 98.92 Very High Very High Very High
Pancreatic Cancer 162 98.38 Very High Very High Very High
Pancreatitis 6 75.12 Quite High
Skin Cancer 4 75.12 Quite High
Stress 5 71.20 Quite High
Anaemia 3 64.40 Quite High
Carcinoma 4 63.12 Quite High
Brain Tumor 4 56.40 Quite High
Breast Cancer 48 55.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, an electrophoretic mobility shift assay (EMSA) from nuclear extracts from melanoma cells showed a decrease in constitutive activation of NF-kappaB and enhanced HIF-1alpha binding activity to hypoxia response element (HRE) in melanoma cells treated with different concentrations of capsaicin.
Positive_regulation (enhanced) of HIF-1alpha Binding (activity) of
1) Confidence 0.45 Published 2002 Journal J. Cancer Res. Clin. Oncol. Section Body Doc Link 12242509 Disease Relevance 0.08 Pain Relevance 0
stabilization and translocation to the cell nucleus, dimerization with HIF-1?
Positive_regulation (stabilization) of HIF-1 Binding (dimerization) of in nucleus
2) Confidence 0.26 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 0.58 Pain Relevance 0.03
In vitro all pancreatic cancer cell lines increased VEGF production under low oxygen levels by highly specific activation of HIF-1 DNA binding activity to the VEGF promotor [43].
Positive_regulation (activation) of HIF-1 Binding (activity) of associated with pancreatic cancer
3) Confidence 0.24 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 1.47 Pain Relevance 0.08
Hydroxylation increases the affinity of HIF-1?
Positive_regulation (increases) of HIF-1 Binding (affinity) of
4) Confidence 0.21 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.84 Pain Relevance 0
For instance, obstructing the interaction between HIF-1?
Positive_regulation (obstructing) of HIF-1 Binding (interaction) of
5) Confidence 0.09 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246178 Disease Relevance 0.87 Pain Relevance 0

General Comments

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