INT105403

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Context Info
Confidence 0.60
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 7.99
Pain Relevance 4.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CCR3) extracellular space (CCR3) cell adhesion (CCR3)
plasma membrane (CCR3) signal transducer activity (CCR3)
Anatomy Link Frequency
eosinophils 6
macrophage 4
1C6 2
NHA 2
mononuclear cells 2
CCR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 39 99.60 Very High Very High Very High
Morphine 20 99.36 Very High Very High Very High
chemokine 57 99.34 Very High Very High Very High
Opioid 19 98.20 Very High Very High Very High
antagonist 7 92.48 High High
narcan 3 88.00 High High
opiate 5 83.52 Quite High
cytokine 66 68.12 Quite High
Angina 6 50.00 Quite Low
Inflammatory marker 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 27 100.00 Very High Very High Very High
INFLAMMATION 44 99.60 Very High Very High Very High
Gastroesophageal Reflux Disease 72 98.96 Very High Very High Very High
Encephalopathy 2 97.68 Very High Very High Very High
Hookworm Infection 105 97.60 Very High Very High Very High
Infection 90 97.08 Very High Very High Very High
Disease Progression 3 93.16 High High
Glioblastoma 1 92.88 High High
Eosinophilic Esophagitis 212 92.48 High High
Anaplastic Astrocytoma 4 92.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment of NHAs with morphine suppressed IL-8 and macrophage-inflammatory protein-1beta gene expression, whereas expression of their receptor genes, CCR3 and CCR5, was simultaneously enhanced.
Positive_regulation (enhanced) of Gene_expression (expression) of CCR3 in macrophage associated with inflammation and morphine
1) Confidence 0.60 Published 2002 Journal J. Immunol. Section Abstract Doc Link 12244149 Disease Relevance 1.15 Pain Relevance 1.37
Although the parasite has developed the ability to specifically cleave eotaxin, hypothetically inhibiting eosinophil recruitment [35], the upregulation of CCR3 expression may counterbalance this effect.
Positive_regulation (upregulation) of Gene_expression (expression) of CCR3 in eosinophil
2) Confidence 0.48 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.60 Pain Relevance 0.05
Our results show that NHA treated with morphine showed significant downregulation of the gene expression of beta chemokines, MCP-1, and MIP-1 beta, while reciprocally upregulating the expression of their specific receptors, CCR2b, CCR3, and CCR5 as detected by real-time quantitative PCR.
Positive_regulation (upregulating) of Gene_expression (expression) of CCR3 in NHA associated with chemokine and morphine
3) Confidence 0.44 Published 2005 Journal Clin. Immunol. Section Abstract Doc Link 15893700 Disease Relevance 0 Pain Relevance 0.87
Our results support the hypothesis that opioids play a significant role in the susceptibility of the CNS to HIV-1 infection and subsequent encephalopathy by inhibiting local production of HIV-1-protective chemokines (IL-8 and macrophage-inflammatory protein-1beta) and enhancing expression of HIV-1 entry coreceptor genes (CCR3, CCR5, and CXCR2) within the CNS.
Positive_regulation (enhancing) of Gene_expression (expression) of CCR3 in macrophage associated with chemokine, inflammation, encephalopathy, acquired immune deficiency syndrome or hiv infection, opioid and infection
4) Confidence 0.44 Published 2002 Journal J. Immunol. Section Abstract Doc Link 12244149 Disease Relevance 0.83 Pain Relevance 1.30
Our results indicate that treatment of U373 cells with morphine significantly downregulated the gene expression of the beta chemokine, MIP-1 beta, while reciprocally upregulating the expression of its specific receptors, CCR3 and CCR5 suggesting that the capacity of mu-opioids to increase HIV-1 co-receptor expression may promote viral binding, trafficking of HIV-1-infected cells, and enhanced disease progression.
Positive_regulation (upregulating) of Gene_expression (expression) of CCR3 associated with chemokine, acquired immune deficiency syndrome or hiv infection, opioid, disease progression and morphine
5) Confidence 0.43 Published 2005 Journal Curr. HIV Res. Section Abstract Doc Link 16022659 Disease Relevance 1.41 Pain Relevance 0.97
Moreover, we have demonstrated that activated eosinophils express relatively higher levels of the eotaxin receptor (CCR3), suggesting that these cells may be recruited to sites of inflammation.
Positive_regulation (levels) of Gene_expression (express) of CCR3 in eosinophils associated with inflammation
6) Confidence 0.35 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.55 Pain Relevance 0.05
Moreover, we have demonstrated that activated eosinophils express relatively higher levels of the eotaxin receptor (CCR3), suggesting that these cells may be recruited to sites of inflammation.
Positive_regulation (levels) of Gene_expression (express) of eotaxin receptor in eosinophils associated with inflammation
7) Confidence 0.35 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.55 Pain Relevance 0.05
1 1:6 (CD49d clone P4C2, CYTEL CORPORATION, San Diego, CA, USA) or incubated for two hours at room temperature with one of the following mAbs: mouse anti-human CXCR3 (clone 1C6), anti-CCR5 (clone 2D7), anti-CCR3 (clone 7B11), anti-CCL17/TARC (clone 2D8) at 10 ?
Positive_regulation (incubated) of Gene_expression (one) of CCR3 in 1C6
8) Confidence 0.28 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0 Pain Relevance 0.09
CCR3, the eotaxin-3 receptor, also had an increased expression factor of 2× compared to GERD and HC (Figure 1b).
Positive_regulation (increased) of Gene_expression (expression) of CCR3 associated with gastroesophageal reflux disease
9) Confidence 0.23 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 1.34 Pain Relevance 0
CCR3, the eotaxin-3 receptor, also had an increased expression factor of 2× compared to GERD and HC (Figure 1b).
Positive_regulation (increased) of Gene_expression (expression) of eotaxin-3 receptor associated with gastroesophageal reflux disease
10) Confidence 0.23 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 1.34 Pain Relevance 0
Peripheral blood mononuclear cells showed increased protein expression of chemokine receptors CCR3 and CCR5 in CD3+ and CD14+ cells at baseline compared with 180 days after inclusion, whereas mRNA levels were downregulated, which was attributable in part to a postischemic release of human neutrophil peptide-3-positive neutrophils and in part to negative feedback.
Positive_regulation (increased) of Gene_expression (expression) of chemokine receptors CCR3 in mononuclear cells
11) Confidence 0.08 Published 2007 Journal Circulation Section Body Doc Link 17909104 Disease Relevance 0.23 Pain Relevance 0

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