INT10542

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Context Info
Confidence 0.71
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 3.70
Pain Relevance 4.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (DLL1) extracellular region (DLL1) plasma membrane (DLL1)
cell-cell signaling (DLL1)
Anatomy Link Frequency
PC-3 2
SH-SY5Y 1
lateral 1
brain 1
LGL 1
DLL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 10 100.00 Very High Very High Very High
Opioid 10 100.00 Very High Very High Very High
Calcium channel 8 100.00 Very High Very High Very High
antagonist 7 99.74 Very High Very High Very High
agonist 10 99.42 Very High Very High Very High
rheumatoid arthritis 8 98.28 Very High Very High Very High
spinal inflammation 1 96.80 Very High Very High Very High
tetrodotoxin 3 95.76 Very High Very High Very High
opiate 2 94.96 High High
Analgesic 1 94.56 High High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 2 99.92 Very High Very High Very High
Neuroblastoma 6 99.52 Very High Very High Very High
Hypertension 4 98.84 Very High Very High Very High
Rheumatoid Arthritis 8 98.28 Very High Very High Very High
Low Back Pain 1 96.80 Very High Very High Very High
Diabetes Mellitus 6 96.24 Very High Very High Very High
Neutropenia 2 94.92 High High
Arthritis 1 94.28 High High
Disease 4 86.36 High High
Reprotox - General 1 12 80.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, decreasing Dll1 expression increased the lateral motility of PC-3 cells, whereas blocking voltage-gated Na(+) channel activity with tetrodotoxin decreased motility.
Gene_expression (expression) of Dll1 in lateral associated with tetrodotoxin
1) Confidence 0.71 Published 2006 Journal Prostate Cancer Prostatic Dis. Section Abstract Doc Link 16832382 Disease Relevance 0.29 Pain Relevance 0.13
The present study aimed to investigate the pharmacological properties of delta1- and delta2-opioid subtypes expressed in the human neuroblastoma cell line SK-N-BE and to characterize their putative corresponding mRNAs.
Gene_expression (expressed) of delta1 associated with neuroblastoma and opioid
2) Confidence 0.69 Published 2000 Journal Biochem. Pharmacol. Section Abstract Doc Link 10692556 Disease Relevance 0.17 Pain Relevance 0.48
In SH-SY5Y cells delta-receptor mediated elevation of [Ca2+]i is mediated by a population of receptors, which does not discriminate between agonists and antagonists purportedly selective for delta 1 or delta 2 receptors.
Gene_expression (selective) of delta 1 in SH-SY5Y associated with antagonist and agonist
3) Confidence 0.65 Published 1997 Journal Neuropharmacology Section Abstract Doc Link 9144649 Disease Relevance 0 Pain Relevance 0.54
The first patient with RA showed an expansion of a heterogeneous CD2+ CD16+ CD56- LGL population, of which 30% coexpressed TCR1 with V delta 1 rearrangement.
Gene_expression (coexpressed) of delta 1 in LGL associated with rheumatoid arthritis
4) Confidence 0.65 Published 1994 Journal Rheumatol. Int. Section Abstract Doc Link 7871335 Disease Relevance 1.13 Pain Relevance 0.48
Co-expression of Ca(V)alpha(2)delta-1 significantly increased macroscopic currents and conferred the Ca(V)1.3alpha(1)/Ca(V)beta(3) channels sensitivity to the antiepileptic/analgesic drugs gabapentin and AdGABA.
Gene_expression (Co-expression) of delta-1 associated with analgesic and gabapentin
5) Confidence 0.58 Published 2009 Journal Cell Calcium Section Abstract Doc Link 19796812 Disease Relevance 0 Pain Relevance 0.23
In contrast, the Notch ligand Delta-like1 (Dll1) levels were higher in LNCaP compared with PC-3 and PC-3M cells.
Gene_expression (levels) of Delta-like1 in PC-3
6) Confidence 0.58 Published 2006 Journal Prostate Cancer Prostatic Dis. Section Abstract Doc Link 16832382 Disease Relevance 0.31 Pain Relevance 0.12
In contrast, the Notch ligand Delta-like1 (Dll1) levels were higher in LNCaP compared with PC-3 and PC-3M cells.
Gene_expression (levels) of Dll1 in PC-3
7) Confidence 0.55 Published 2006 Journal Prostate Cancer Prostatic Dis. Section Abstract Doc Link 16832382 Disease Relevance 0.31 Pain Relevance 0.12
The alpha(2)delta-4a subunit shares 30, 32, and 61% identity with the human calcium channel alpha(2)delta-1, alpha(2)delta-2, and alpha(2)delta-3 subunits, respectively.
Gene_expression (respectively) of delta-1 associated with calcium channel
8) Confidence 0.18 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12181424 Disease Relevance 0 Pain Relevance 0.30
The alpha(2)delta-4a subunit shares 30, 32, and 61% identity with the human calcium channel alpha(2)delta-1, alpha(2)delta-2, and alpha(2)delta-3 subunits, respectively.
Gene_expression (shares) of delta-1 associated with calcium channel
9) Confidence 0.18 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12181424 Disease Relevance 0 Pain Relevance 0.29
Human alpha2delta-1, -2, and -3 mRNAs were detected in all portions of brain tested.
Gene_expression (detected) of alpha2delta-1 in brain
10) Confidence 0.14 Published 2001 Journal J. Membr. Biol. Section Abstract Doc Link 11687876 Disease Relevance 0 Pain Relevance 0.25
Biochemical and pharmacological characterization of mu, delta and kappa 3 opioid receptors expressed in BE(2)-C neuroblastoma cells.
Gene_expression (expressed) of delta associated with neuroblastoma and opioid receptor
11) Confidence 0.12 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 7932177 Disease Relevance 0.25 Pain Relevance 0.56
Delta Agatston score was significantly higher in hypertensive (p < 0.020) compared to non hypertensive HD patients

Discussion

Gene_expression (score) of Delta associated with hypertension
12) Confidence 0.11 Published 2010 Journal BMC Nephrol Section Body Doc Link PMC2903573 Disease Relevance 0.97 Pain Relevance 0
The good correlation (r = 0.82; p less than 0.001) observed between the glucuronidation of VPA and delta 2-VPA as well as the mutual inhibition of each other's glucuronidation strongly suggests that (a) common single UDP-glucuronosyltransferase isoenzyme(s) was (were) involved in this glucuronidation step.
Gene_expression (glucuronidation) of delta
13) Confidence 0.10 Published 1992 Journal Pharm Weekbl Sci Section Abstract Doc Link 1502016 Disease Relevance 0 Pain Relevance 0.13
The sum of the Bmax values in the selective binding assays (370 +/- 39 fmol/mg protein) approximates closely that observed with 3H-diprenorphine, suggesting that mu, delta and kappa 3 sites account for most of the binding.
Gene_expression (account) of delta
14) Confidence 0.06 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932177 Disease Relevance 0.21 Pain Relevance 0.58
Niger Delta region (Nigeria): fragmented health services amidst rebellion
Gene_expression (region) of Delta
15) Confidence 0.06 Published 2008 Journal Global Health Section Body Doc Link PMC2596095 Disease Relevance 0.06 Pain Relevance 0
See examples mentioned in Appendix 1, sections on the Niger Delta and southern Chad.
Gene_expression (sections) of Delta in Appendix
16) Confidence 0.06 Published 2008 Journal Global Health Section Body Doc Link PMC2596095 Disease Relevance 0 Pain Relevance 0

General Comments

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