INT105422

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Context Info
Confidence 0.31
First Reported 2002
Last Reported 2002
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk) aging (Fosl2) nucleolus (Fosl2)
nucleus (Fosl2) DNA binding (Fosl2) response to stress (Fosl2)
Anatomy Link Frequency
adrenal medulla 2
Fosl2 (Rattus norvegicus)
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nicotine 10 100.00 Very High Very High Very High
medulla 4 96.64 Very High Very High Very High
Enkephalin 1 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that proENK mRNA expression induced by repeated nicotine administrations may be mediated by AP-1 proteins, such as c-Fos, c-Jun and Fra-2 rather than CREB via interacting to the ENKCRE-2 DNA binding domain in rat adrenal medulla.
Fra-2 Spec (may) Positive_regulation (mediated) of Gene_expression (expression) of proENK mRNA in adrenal medulla associated with medulla and nicotine
1) Confidence 0.31 Published 2002 Journal Life Sci. Section Abstract Doc Link 12269402 Disease Relevance 0 Pain Relevance 0.55

General Comments

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