INT105435

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Context Info
Confidence 0.25
First Reported 2002
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.45
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNF, IL6) extracellular region (TNF, IL6) signal transduction (TNF)
aging (IL6) plasma membrane (TNF) intracellular (TNF)
Anatomy Link Frequency
plaque 1
decidua 1
TNF (Homo sapiens)
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 29 100.00 Very High Very High Very High
Dismenorea 1 97.80 Very High Very High Very High
Inflammatory response 5 90.00 High High
Inflammatory mediators 2 88.64 High High
Inflammation 33 87.04 High High
interstitial cystitis 1 84.48 Quite High
antagonist 3 79.12 Quite High
Abeta 2 70.48 Quite High
Inflammatory marker 1 61.28 Quite High
metalloproteinase 6 25.52 Quite Low
Disease Link Frequency Relevance Heat
Disease 17 100.00 Very High Very High Very High
Cancer 10 100.00 Very High Very High Very High
Necrosis 8 100.00 Very High Very High Very High
Infection 10 99.78 Very High Very High Very High
Alzheimer's Dementia 1 99.52 Very High Very High Very High
Dysmenorrhea 1 97.80 Very High Very High Very High
Obesity 43 96.88 Very High Very High Very High
Insulin Resistance 16 96.52 Very High Very High Very High
Polycystic Ovary Syndrome 83 92.60 High High
Hypertension 12 91.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
COX-2 immunoreactivity and mRNA were induced by lipopolysaccharide (LPS), not by AD plaque associated cytokines interleukin (IL)-1alpha, IL-1beta, IL-6, tumor necrosis factor (TNF)-alpha, or amyloid (A)beta(1-42).
TNF Neg (not) Positive_regulation (induced) of IL-6 in plaque associated with necrosis, cancer, alzheimer's dementia, disease and cytokine
1) Confidence 0.25 Published 2002 Journal Brain Res. Section Abstract Doc Link 12270500 Disease Relevance 0.75 Pain Relevance 0.12
IL-6 is stimulated by TNF-alpha: TNF stimulates C-reactive protein that has been found to be correlated with obesity, insulin resistance, endothelial dysfunction, and therefore cardiovascular risk, and patients with PCOS have been shown to have a higher level of CRP (Kelly et al 2001; Bahceci et al 2004).
TNF-alpha Positive_regulation (stimulated) of IL-6 associated with obesity, polycystic ovary syndrome and insulin resistance
2) Confidence 0.21 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994046 Disease Relevance 1.53 Pain Relevance 0.06
In the setting of infection, IL-1 and TNF have a synergistic effect on the acute phase cytokine IL-6 with increased production in trophoblasts and chorion and to a lesser extent decidua [5].
TNF Positive_regulation (effect) of IL-6 in decidua associated with infection and cytokine
3) Confidence 0.16 Published 2005 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC554771 Disease Relevance 1.19 Pain Relevance 0.52
We investigated whether HDSMCs are capable of expressing and releasing MCP-1, IL-6 and SCF in response to IL-4, IL-13, IL-1beta and tumor necrosis factor-alpha.
tumor necrosis factor-alpha Positive_regulation (response) of IL-6 associated with necrosis and cancer
4) Confidence 0.12 Published 2006 Journal J. Urol. Section Abstract Doc Link 16407046 Disease Relevance 0.60 Pain Relevance 0.08
The production of PGE2, MMP-1, IL-8, IL-6, RANTES and IP-10 induced by hTWEAK (but not the production induced by TNF and IL-1?)
TNF Positive_regulation (induced) of IL-6
5) Confidence 0.04 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.38 Pain Relevance 0.04

General Comments

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