INT105445

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.71
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.11
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HMOX1) endoplasmic reticulum (HMOX1) enzyme binding (HMOX1)
transmembrane transport (HMOX1) signal transducer activity (HMOX1) cytosol (HMOX1)
Anatomy Link Frequency
microglia 1
HMOX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 9 99.76 Very High Very High Very High
COX2 2 99.76 Very High Very High Very High
cOX1 2 99.76 Very High Very High Very High
agonist 1 95.68 Very High Very High Very High
Inflammation 4 94.68 High High
antagonist 1 89.48 High High
aspirin 3 87.28 High High
cINOD 5 80.64 Quite High
Inflammatory response 4 77.20 Quite High
tolerance 2 70.40 Quite High
Disease Link Frequency Relevance Heat
Stress 11 98.08 Very High Very High Very High
Disease 50 97.40 Very High Very High Very High
INFLAMMATION 8 94.68 High High
Atherosclerosis 3 87.20 High High
Injury 3 86.80 High High
Nicotine Addiction 14 79.12 Quite High
Cancer 33 77.32 Quite High
Lung Cancer 12 77.28 Quite High
Necrosis 3 77.08 Quite High
Alzheimer's Dementia 1 75.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HO-1 induction subsequently led to a marked increase in protein expression of a second antioxidant protein, ferritin, via the HO-1-dependent release of free iron from endogenous heme sources (Figures 1 and 5).
Localization (release) of HO-1-dependent
1) Confidence 0.71 Published 2004 Journal Herz Section Abstract Doc Link 14968347 Disease Relevance 0.36 Pain Relevance 0.09
Similarly to inhibition of prostacyclin biosynthesis or activity, the novel imidazole-based HO-1 inhibitor QC15 reversed TNF-alpha reduction by LSS.
Localization (based) of HO-1 associated with stress
2) Confidence 0.65 Published 2009 Journal Circ. Res. Section Abstract Doc Link 19122175 Disease Relevance 0.73 Pain Relevance 0.37
SOCS3 (suppressor of cytokine signaling 3) was observed early, while BTSs related to HMOX1 (heme oxygenase 1), CSF2 (colony stimulating factor 2), and SPP1 (secreted phosphoprotein 1) were observed throughout the 24-h period.
Localization (secreted) of heme oxygenase 1 associated with cytokine
3) Confidence 0.51 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2900289 Disease Relevance 0.67 Pain Relevance 0.13
SOCS3 (suppressor of cytokine signaling 3) was observed early, while BTSs related to HMOX1 (heme oxygenase 1), CSF2 (colony stimulating factor 2), and SPP1 (secreted phosphoprotein 1) were observed throughout the 24-h period.
Localization (secreted) of HMOX1 associated with cytokine
4) Confidence 0.51 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2900289 Disease Relevance 0.67 Pain Relevance 0.14
The PCR condition, as well as Taqman probes and primers for Nrf2, NQO1, heme oxygenase-1 (HO-1), and GAPDH were reported previously (Wang et al. 2007).
Localization (reported) of HO-1
5) Confidence 0.36 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 0 Pain Relevance 0
The role of cyclo-oxygenase 1 and 2 activity in prostaglandin E(2) secretion by cultured human adult microglia: implications for Alzheimer's disease.
Localization (secretion) of cyclo-oxygenase 1 in microglia associated with disease and cox1
6) Confidence 0.07 Published 2002 Journal Brain Res. Section Title Doc Link 12270500 Disease Relevance 0.68 Pain Relevance 0.25

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox