INT10546

Context Info Confidence 0.44 First Reported 1982 Last Reported 2009 Negated 0 Speculated 2 Reported most in Abstract Documents 12 Total Number 14 Disease Relevance 4.57 Pain Relevance 10.05

peptidase activity (Prss12)

Anatomy Link Frequency PAG 2 nucleus accumbens 1 bile 1 central nervous system 1 Prss12 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Bile 22 99.84 Analgesic 15 99.78 Central nervous system 4 99.68 Morphine 8 99.54 gABA 20 99.40 Hyperalgesia 3 99.00 substance P 4 98.52 agonist 56 97.86 opioid receptor 6 97.52 antagonist 12 97.28

Disease Link Frequency Relevance Heat Hyperalgesia 4 99.00 Stress 5 96.36 Urological Neuroanatomy 40 95.92 Heat Stress Disorders 2 93.28 Hypothermia 3 92.80 Targeted Disruption 3 91.16 Nociception 53 89.20 Sprains And Strains 3 88.64 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 1 86.28 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super / Visceral Pain 3 83.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

NT was also required for acetic acid-induced hyperalgesia.

Positive_regulation (required) of NT associated with hyperalgesia

1) Confidence 0.44 Published 2004 Journal Neuroscience Section Abstract Doc Link 15207335 Disease Relevance 1.27 Pain Relevance 1.03

Luminal infusion of oleic acid (sodium salt; 100 mM) increased by 100% the level of NT-LI in the portal effluent, whereas 20 mM oleate had no effect.

Positive_regulation (increased) of NT

2) Confidence 0.38 Published 1994 Journal Endocrinology Section Abstract Doc Link 8299558 Disease Relevance 0 Pain Relevance 0.47

Fischer and Lewis rats exhibit differential behavioral responses to central NT receptor activation.

Positive_regulation (activation) of NT

3) Confidence 0.32 Published 2003 Journal Peptides Section Abstract Doc Link 14612190 Disease Relevance 0.40 Pain Relevance 0.35

In contrast, the micellar form of oleic acid (20 and 100 mM) in bile extract (1%) or TC (20 mM) dose dependently reduced the release of NT-LI induced by bile extract or TC alone.

Positive_regulation (induced) of NT in bile associated with bile

4) Confidence 0.22 Published 1994 Journal Endocrinology Section Abstract Doc Link 8299558 Disease Relevance 0 Pain Relevance 0.49

NT-induced increase in sIPSC frequency was blocked by application of the specific NTS1 antagonist SR48692, the phospholipase C (PLC) inhibitor U73122, the IP(3) receptor antagonist 2-APB, and the protein kinase C inhibitor GF109203X, suggesting that NT increases gamma-aminobutyric acid release via a PLC pathway.

Positive_regulation (increase) of NT-induced associated with antagonist and kinase c inhibitor

5) Confidence 0.21 Published 2008 Journal J. Neurophysiol. Section Abstract Doc Link 18337367 Disease Relevance 0 Pain Relevance 0.71

Our results indicate that additionally to the secretion of NT induced by cholinergic agents and bombesin, substance P and to a lesser extent Leu-enkephalin are capable of stimulating NT release in the rat.

Positive_regulation (induced) of NT associated with enkephalin and substance p

6) Confidence 0.20 Published 1991 Journal Regul. Pept. Section Abstract Doc Link 1674614 Disease Relevance 0 Pain Relevance 0.69

However, both basal GABA levels and responsitivity to NT were elevated in the presence of neo.

Positive_regulation (elevated) of NT associated with gaba

7) Confidence 0.16 Published 1992 Journal Brain Res. Section Abstract Doc Link 1504761 Disease Relevance 0 Pain Relevance 0.51

Neurotensin (NT), an endogenous tridecapeptide, is heterogeneously distributed in the central nervous system.

Positive_regulation (distributed) of NT in central nervous system associated with central nervous system

8) Confidence 0.15 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6811728 Disease Relevance 0 Pain Relevance 0.24

Also perfusion of the dialysis probe with the mu-opioid receptor-specific agonist [D-Ala2-N-Me-Phe4-Gly5-ol]-enkephaline (DAGO) (1 or 100 microM) induced a significant (P < 0.05; n = 7-9) increase of the NT-LI level.

Positive_regulation (increase) of NT associated with agonist and opioid receptor

9) Confidence 0.13 Published 1997 Journal Brain Res. Section Abstract Doc Link 9452203 Disease Relevance 0.63 Pain Relevance 1.27

Perfusion of the microdialysis probe with 10 microM morphine induced a significant increase (P < 0.05; n = 5) of the extracellular level of NT-like immunoreactivity (NT-LI), while perfusion with a 10-fold higher concentration of morphine had no significant effect on the NT-LI release in the PAG.

Spec (like) Positive_regulation (increase) of NT in PAG associated with urological neuroanatomy and morphine

10) Confidence 0.09 Published 1997 Journal Brain Res. Section Abstract Doc Link 9452203 Disease Relevance 0.59 Pain Relevance 1.09

Significant elevation in blood CS, ACTH, beta-EP, and NT in the hypothalamus and significant reductions in splenic NKCA and NT in the nucleus accumbens were produced by heat.

Positive_regulation (elevation) of NT in nucleus accumbens associated with nucleus accumbens

11) Confidence 0.08 Published 1997 Journal Brain Behav. Immun. Section Abstract Doc Link 9299063 Disease Relevance 0.17 Pain Relevance 0.12

Perfusion of the microdialysis probe with 10 microM morphine induced a significant increase (P < 0.05; n = 5) of the extracellular level of NT-like immunoreactivity (NT-LI), while perfusion with a 10-fold higher concentration of morphine had no significant effect on the NT-LI release in the PAG.

Spec (like) Positive_regulation (increase) of NT in PAG associated with urological neuroanatomy and morphine

12) Confidence 0.08 Published 1997 Journal Brain Res. Section Abstract Doc Link 9452203 Disease Relevance 0.59 Pain Relevance 1.08

The increase in NT-LI release in response to 1 microM DAGO was both calcium-dependent and naloxone-reversible.

Positive_regulation (increase) of NT associated with narcan

13) Confidence 0.08 Published 1997 Journal Brain Res. Section Abstract Doc Link 9452203 Disease Relevance 0.63 Pain Relevance 1.32

However, there is now evidence that the analgesic action of NT is mediated through activation of both G-protein coupled receptors, NTS1 and NTS2 [1,10-12].

Positive_regulation (mediated) of NT associated with analgesic

14) Confidence 0.07 Published 2009 Journal Mol Pain Section Body Doc Link PMC2714839 Disease Relevance 0.08 Pain Relevance 0.69

General Comments

This test has worked.