INT10547

Context Info Confidence 0.41 First Reported 1983 Last Reported 2009 Negated 6 Speculated 2 Reported most in Abstract Documents 11 Total Number 13 Disease Relevance 3.11 Pain Relevance 5.74

peptidase activity (Prss12)

Anatomy Link Frequency cortex 2 dorsal 1 PAG 1 lungs 1 hippocampus 1 Prss12 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Dynorphin 6 100.00 substance P 5 99.80 Morphine 12 99.64 Antinociceptive 14 99.18 agonist 48 99.12 gABA 30 98.90 Dopamine 10 98.60 GABAergic 5 98.48 Pain 47 98.28 antagonist 12 98.24

Disease Link Frequency Relevance Heat Aging 8 99.34 Urological Neuroanatomy 19 99.32 Pain 62 98.28 Lung Cancer 1 88.60 Hypothermia 8 82.12 Nociception 45 81.72 Pulmonary Disease 1 75.40 Fever 6 72.48 INFLAMMATION 16 57.32 Cancer 1 38.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Nor-binaltorphimine (25 nmol i.c.v.) partially blocked the effect of U50 on Tb and had no effect on NT or U50/NT.

Neg (no) Regulation (effect) of NT

1) Confidence 0.41 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7616410 Disease Relevance 0.51 Pain Relevance 0.43

The effects of neurotensin (NT) on the K+-evoked release of endogenous and tritiated dopamine in striatum and on 3H-dopamine in slices from nucleus accumbens and prefrontal cortex were investigated.

Spec (investigated) Regulation (effects) of NT in cortex associated with nucleus accumbens and dopamine

2) Confidence 0.38 Published 1988 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 3368012 Disease Relevance 0 Pain Relevance 0.32

The effects of neurotensin (NT) alone or in combination with the dopamine antagonist sulpiride were tested on the release of endogenous acetylcholine (ACh) from striatal slices.

Regulation (effects) of NT associated with dopamine and antagonist

3) Confidence 0.31 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1899109 Disease Relevance 0 Pain Relevance 0.25

In the present study, we report that VIP is significantly increased in the lungs and BAL fluids of rats exposed to asbestos while no significant change in the levels of Leu-Enk, Dyn, NT and SP is observed.

Neg (no) Regulation (change) of NT in lungs associated with dynorphin and substance p

4) Confidence 0.18 Published 1983 Journal Life Sci. Section Abstract Doc Link 6196589 Disease Relevance 0.16 Pain Relevance 0.24

Nor-binaltorphimine (25 nmol i.c.v.) partially blocked the effect of U50 on Tb and had no effect on NT or U50/NT.

Neg (no) Regulation (effect) of NT

5) Confidence 0.18 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7616410 Disease Relevance 0.51 Pain Relevance 0.43

The effects of local perfusion with the tridecapeptide neurotensin (NT) on endogenous gamma-aminobutyric acid (GABA), acetylcholine (ACh) and choline release in the dorsal neostriatum were monitored using in vivo microdialysis in the halothane anaesthetized rat.

Regulation (effects) of NT in dorsal associated with gaba and halothane

6) Confidence 0.16 Published 1992 Journal Brain Res. Section Abstract Doc Link 1504761 Disease Relevance 0 Pain Relevance 0.24

In contrast to PE mRNA, neither aging nor chronic ethanol consumption affected NT/NN mRNA in the regions analyzed.

Neg (neither) Regulation (affected) of NT associated with aging

7) Confidence 0.12 Published 1998 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 9726289 Disease Relevance 0.69 Pain Relevance 0.25

The purpose of this study is to determine whether the antinociceptive properties of morphine and neurotensin (NT) are dependent upon central serotonergic neurotransmission.

Spec (whether) Regulation (dependent) of NT associated with antinociceptive and morphine

8) Confidence 0.11 Published 1984 Journal Brain Res. Section Abstract Doc Link 6089968 Disease Relevance 0.14 Pain Relevance 0.62

Naloxone (Nx) administered i.c.v. fully antagonized the intestinal inhibition of i.c.v. morphine, but did not significantly alter the NT effect.

Neg (not) Regulation (alter) of NT associated with narcan and morphine

9) Confidence 0.08 Published 1987 Journal Regul. Pept. Section Abstract Doc Link 3107088 Disease Relevance 0.23 Pain Relevance 0.51

However, this peptide was also effective in attenuating the flinching, licking and biting responses (70 ± 15% maximum antagonism, P < 0.01; Fig. 4B), indicating that this NT analog affects both spinally and supraspinally processed pain-related behaviors.

Regulation (affects) of NT associated with pain

10) Confidence 0.06 Published 2009 Journal Mol Pain Section Body Doc Link PMC2714839 Disease Relevance 0.46 Pain Relevance 0.59

The effects of neurotensin (NT) on the release of acetylcholine (ACh), aspartate (Asp), glutamate (Glu) and gamma-aminobutyric acid (GABA) from the hippocampus of freely moving rats were studied by transversal microdialysis.

Regulation (effects) of NT in hippocampus associated with gaba, glutamate and hippocampus

11) Confidence 0.05 Published 1998 Journal Neurochem. Int. Section Abstract Doc Link 9840224 Disease Relevance 0 Pain Relevance 0.43

However, local administration in the PAG of the GABA(A) antagonist bicuculline (0.1-10 microM) or the GABA(A) agonist muscimol (1-100 microM) had no significant effect on the extracellular NT-LI level in the PAG, suggesting that GABAergic mechanisms are not involved in the opioid-induced release of NT-LI.

Neg (no) Regulation (effect) of NT in PAG associated with gaba, gabaergic, antagonist, agonist, urological neuroanatomy and opioid

12) Confidence 0.04 Published 1997 Journal Brain Res. Section Abstract Doc Link 9452203 Disease Relevance 0.40 Pain Relevance 1.12

The effects of the peptide transmitter neurotensin (NT) on the release of acetylcholine (ACh), gamma-aminobutyric acid (GABA), glutamate (Glu), aspartate (Asp), and taurine from the prefrontal cortex (PFC) of freely moving rats were studied by transversal microdialysis.

Regulation (effects) of NT in cortex associated with glutamate and gaba

13) Confidence 0.03 Published 2008 Journal Brain Res. Bull. Section Abstract Doc Link 18721670 Disease Relevance 0 Pain Relevance 0.31

General Comments

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