INT105483

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Context Info
Confidence 0.42
First Reported 2002
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 3.26
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LNPEP) peptidase activity (LNPEP) extracellular region (LNPEP)
plasma membrane (LNPEP) intracellular (LNPEP) cell-cell signaling (LNPEP)
Anatomy Link Frequency
blood 2
placenta 1
LNPEP (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 10 99.56 Very High Very High Very High
antagonist 31 98.20 Very High Very High Very High
Dismenorea 12 92.88 High High
depression 5 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
anticonvulsant 5 5.00 Very Low Very Low Very Low
Kinase C 5 5.00 Very Low Very Low Very Low
Potency 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pre-eclampsia 230 100.00 Very High Very High Very High
Pre-term Labor 137 100.00 Very High Very High Very High
Targeted Disruption 10 95.24 Very High Very High Very High
Dysmenorrhea 12 92.88 High High
Hypoxia 10 86.48 High High
Hypertension 135 85.76 High High
Adverse Drug Reaction 10 85.12 High High
Premature Birth 30 81.92 Quite High
Increased Venous Pressure Under Development 15 79.44 Quite High
Acidosis 5 67.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The degradation of these peptide hormones by P-LAP in the placenta is necessary in order to maintain homeostasis for both fetus and mother.
Protein_catabolism (degradation) of P-LAP in placenta
1) Confidence 0.42 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.41 Pain Relevance 0.14
Therefore, it is suggested that the regulation of the onset of labor mainly depends on OT, and its degradation by P-LAP and is therefore, independent of both PG and progesterone.
Protein_catabolism (degradation) of P-LAP
2) Confidence 0.37 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.06 Pain Relevance 0.10
Although P-LAP degrades, the ring structure of OT at the peptide bond between Cys¹ and Tyr² and hydrolyzes the remaining bonds stepwise from the amino terminal.
Protein_catabolism (degrades) of P-LAP
3) Confidence 0.36 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.25 Pain Relevance 0.08
The purpose of this study was to compare the resistance of TT-235 and oxytocin to enzymatic degradation by oxytocinase in the blood of humans and baboons during their 3rd trimester of pregnancy.
Protein_catabolism (degradation) of oxytocinase in blood
4) Confidence 0.36 Published 2002 Journal Gynecol. Obstet. Invest. Section Abstract Doc Link 12297713 Disease Relevance 0.19 Pain Relevance 0.18
This study suggests (1) that in contrast to blood from pregnant humans, blood from pregnant baboons lacks oxytocinase at least in vitro and (2) that TT-235 is resistant to enzymatic degradation by human blood, implying that this oxytocin antagonist may have a prolonged activity in vivo in humans.
Protein_catabolism (degradation) of oxytocinase in blood associated with antagonist
5) Confidence 0.32 Published 2002 Journal Gynecol. Obstet. Invest. Section Abstract Doc Link 12297713 Disease Relevance 0.11 Pain Relevance 0.17
During normal pregnancy, sufficient levels of P-LAP degrade OT and AVP, and APA deactivates AngII, thus protecting the mother.
Protein_catabolism (degrade) of P-LAP
6) Confidence 0.27 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.93 Pain Relevance 0.07
We then discuss the roles of P-LAP and APA as promising agents to treat preeclampsia and preterm labor by degrading bioactive hormones derived from fetoplacental circulation.
Protein_catabolism (degrading) of P-LAP associated with pre-term labor and pre-eclampsia
7) Confidence 0.27 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 1.31 Pain Relevance 0

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