INT105505

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Context Info
Confidence 0.34
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 0.59
Pain Relevance 7.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Vta1)
Anatomy Link Frequency
hypothalamus 1
DA neurons 1
neurons 1
medial 1
brain 1
Vta1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Ventral tegmentum 385 100.00 Very High Very High Very High
gABA 79 100.00 Very High Very High Very High
Nucleus accumbens 101 99.92 Very High Very High Very High
Nicotine 128 99.82 Very High Very High Very High
Enkephalin 12 99.66 Very High Very High Very High
Opioid 19 99.64 Very High Very High Very High
Dopamine 322 99.36 Very High Very High Very High
opioid receptor 45 99.36 Very High Very High Very High
Eae 40 98.36 Very High Very High Very High
Acupuncture 206 97.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 190 75.44 Quite High
Recurrence 14 72.60 Quite High
Opiate Addiction 20 70.00 Quite High
Drug Dependence 62 63.84 Quite High
Li-fraumeni Syndrome 32 51.00 Quite High
Alagille Syndrome 2 34.32 Quite Low
Tremor 2 25.48 Quite Low
Anxiety Disorder 12 5.00 Very Low Very Low Very Low
Cannabis Dependence 8 5.00 Very Low Very Low Very Low
Parkinson's Disease 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Identifying precisely how these lesions influence the dynamics of neuronal interactions in the VTA¬ódo they affect a direct nicotinic activation of DA neurons or is the effect mediated through GABA?
VTA Binding (interactions) of in DA neurons associated with ventral tegmentum, gaba and dopamine
1) Confidence 0.34 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522332 Disease Relevance 0 Pain Relevance 0.55
These results suggest an opioid-mediated feeding association between the VTA and NTS.
VTA Binding (association) of associated with opioid
2) Confidence 0.30 Published 2009 Journal Appetite Section Abstract Doc Link 19748538 Disease Relevance 0 Pain Relevance 0.34
The present data, taken together with the intravenous self-administration studies of Alderson and her colleagues (2006), strengthen the belief that the pPPTg has a role to play in mediating the behavioural effects of nicotine through interaction with the VTA.
VTA Binding (interaction) of associated with ventral tegmentum and nicotine
3) Confidence 0.27 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522332 Disease Relevance 0 Pain Relevance 0.75
CONCLUSION: This finding supports the presence of interactions of opioid and dopaminergic systems in the VTA in mediating ethanol reward, and thus naltrexone attenuates the rewarding properties of ethanol by interfering with the ethanol-induced stimulation of the mesolimbic dopaminergic pathway.


VTA Binding (interactions) of
4) Confidence 0.24 Published 2005 Journal Alcohol Alcohol. Section Body Doc Link 15897221 Disease Relevance 0 Pain Relevance 0
Dual probe microdialysis was employed to characterize the origins of dialysate glutamate, aspartate and gamma-aminobutyric acid (GABA) in the medial prefrontal cortex (mPfc) and to investigate functional interactions between the mPfc and ventral tegmental area (VTA) in awake, freely moving rats.
VTA Binding (interactions) of in medial associated with ventral tegmentum, gaba and glutamate
5) Confidence 0.21 Published 2002 Journal J. Neurosci. Methods Section Abstract Doc Link 12323414 Disease Relevance 0 Pain Relevance 0.63
Moreover, these efferent and afferent regions of the SuM and VTA appear to be closely interlinked.
VTA Binding (interlinked) of associated with ventral tegmentum
6) Confidence 0.18 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2930627 Disease Relevance 0 Pain Relevance 0.58
Using c-Fos as a marker for neuronal activation, we sought to address the following hypotheses: 1) the administration of GABAA receptor antagonist picrotoxin into the SuM activates its' local neurons, because the GABAA receptor antagonist blocks tonic inhibition, leading to neuronal disinhibition; 2) picrotoxin administration into the SuM activates the mesolimbic dopamine system; 3) picrotoxin administration into the SuM activates the brain regions that are involved in motivational processes and reciprocally connected with both SuM and VTA: medial prefrontal cortex, septum, preoptic area, lateral hypothalamic area, and dorsal raphe nucleus.
VTA Binding (connected) of in neurons associated with ventral tegmentum, dopamine, antagonist and raphe
7) Confidence 0.16 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2930627 Disease Relevance 0 Pain Relevance 0.51
To determine whether systemically applied TAT-GluR2 peptide disrupted CPP acquisition by its action in the VTA, we conducted intra-VTA infusion of the peptide (15 pmol) 60 min before each HU210 injection during conditioning (Figure 6B).
VTA Binding (action) of associated with ventral tegmentum
8) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004941 Disease Relevance 0.38 Pain Relevance 0.63
After postconditioning, rats receiving intra-VTA injections were perfused transcardially and brain sections were stained with cresyl violet for verification of cannula placement.


intra-VTA Binding (injections) of in brain associated with ventral tegmentum
9) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004941 Disease Relevance 0 Pain Relevance 0.18
VTA GABA interneurons connect to VTA dopamine neurons and likely inhibit them.
VTA Binding (interneurons) of in dopamine neurons associated with ventral tegmentum, dopamine and gaba
10) Confidence 0.09 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2529396 Disease Relevance 0.06 Pain Relevance 1.71
In negative reinforcement, acupuncture treatment stimulates enkephalin neurons in the hypothalamus, such that methionine-enkephalin released in the VTA interacts with ?
VTA Binding (interacts) of in hypothalamus associated with ventral tegmentum, enkephalin and acupuncture
11) Confidence 0.09 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2529396 Disease Relevance 0.14 Pain Relevance 1.50

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