INT105537

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Context Info
Confidence 0.58
First Reported 2002
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 15
Total Number 18
Disease Relevance 6.97
Pain Relevance 3.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf1) extracellular region (Igf1)
Anatomy Link Frequency
skeletal muscles 4
plasma 2
blood 2
neurons 2
TMJ 2
Igf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 61 100.00 Very High Very High Very High
Inflammation 19 100.00 Very High Very High Very High
qutenza 9 100.00 Very High Very High Very High
Nerve growth factor 8 100.00 Very High Very High Very High
Hippocampus 7 98.16 Very High Very High Very High
Inflammatory response 1 95.88 Very High Very High Very High
Painful diabetic neuropathy 1 94.12 High High
Snapping jaw 3 93.76 High High
Inflammatory mediators 4 92.20 High High
Sciatic nerve 3 91.36 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 23 100.00 Very High Very High Very High
Sprains And Strains 14 99.98 Very High Very High Very High
Atherosclerosis 52 99.24 Very High Very High Very High
Hypertension 7 99.16 Very High Very High Very High
Cancer 157 98.96 Very High Very High Very High
Alopecia 3 98.00 Very High Very High Very High
Coronary Artery Disease 52 97.72 Very High Very High Very High
Fracture Healing 33 96.48 Very High Very High Very High
Diabetic Neuropathy 49 94.12 High High
Temporomandibular Joint Syndrome 3 93.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One possibility to explain them is variation in the sequences that control IGF-1 gene expression.
Regulation (control) of Gene_expression (expression) of IGF-1
1) Confidence 0.58 Published 2010 Journal Protein J Section Abstract Doc Link PMC2951508 Disease Relevance 0.26 Pain Relevance 0.07
In addition, we analyzed serum growth hormone levels in order to examine the effect on systemic IGF-1 synthesis.
Spec (examine) Regulation (effect) of Spec (examine) Gene_expression (synthesis) of IGF-1
2) Confidence 0.58 Published 2010 Journal Protein J Section Abstract Doc Link PMC2951508 Disease Relevance 0.29 Pain Relevance 0.07
Before testing any of these hypotheses, we first wanted to determine the impact of a single genetic variant, which can influence IGF-1 synthesis and the prognosis for patients with a family history of CAD.
Regulation (influence) of Gene_expression (synthesis) of IGF-1 associated with coronary artery disease
3) Confidence 0.58 Published 2010 Journal Protein J Section Body Doc Link PMC2951508 Disease Relevance 0.43 Pain Relevance 0.05
Serum IGF-1 levels were normal in four “other” patients (15.4%) at week 0 and in 12 “other” patients (46.2%) at week 24 or early termination.Fig. 2Serum IGF-1 concentrations at baseline versus week 24 or early termination for switch patients who had these values available at both time points (n = 32)
Regulation (normal) of Gene_expression (levels) of IGF-1
4) Confidence 0.44 Published 2009 Journal Pituitary Section Body Doc Link PMC2855862 Disease Relevance 0.07 Pain Relevance 0.24
By week 24/early termination, IGF-1 levels were controlled in 93.7% of switch and 46.2% of “other” patients, while GH levels were controlled in 76.9% and 39.1% of patients, respectively.
Regulation (controlled) of Gene_expression (levels) of IGF-1
5) Confidence 0.44 Published 2009 Journal Pituitary Section Abstract Doc Link PMC2855862 Disease Relevance 0.25 Pain Relevance 0.07
Serum IGF-1 levels were normal in four “other” patients (15.4%) at week 0 and in 12 “other” patients (46.2%) at week 24 or early termination.Fig. 2Serum IGF-1 concentrations at baseline versus week 24 or early termination for switch patients who had these values available at both time points (n = 32)
Regulation (normal) of Gene_expression (concentrations) of IGF-1
6) Confidence 0.44 Published 2009 Journal Pituitary Section Body Doc Link PMC2855862 Disease Relevance 0.08 Pain Relevance 0.24
Although the reason for the observed difference in discordant IGF-1 and GH levels noted in the current versus previous studies is not clear, one possible explanation may be the use of a single SSA in the current study.
Regulation (difference) of Gene_expression (levels) of IGF-1
7) Confidence 0.44 Published 2009 Journal Pituitary Section Body Doc Link PMC2855862 Disease Relevance 0.34 Pain Relevance 0.04
There were no significant differences in IGF-1 levels, in the degree of coronary atherosclerosis, or in the MI history between patients who were homozygous and those who were heterozygous for the GC repeats.
Neg (no) Regulation (differences) of Gene_expression (levels) of IGF-1 associated with atherosclerosis
8) Confidence 0.42 Published 2010 Journal Protein J Section Body Doc Link PMC2951508 Disease Relevance 0.41 Pain Relevance 0.03
The objective of this in vitro study was to determine if continuous biophysical strain regulates the gene expression of IGF1, IGF2, IGF1 receptor (IGF1R), insulin receptor substrate (IRS1), and IGF-binding proteins (IGFBP) 3 and 5 in cells from the fibrocartilaginous disc of the temporomandibular joint (TMJ).
Regulation (regulates) of Gene_expression (expression) of IGF1 in TMJ associated with snapping jaw and sprains and strains
9) Confidence 0.40 Published 2007 Journal Ann. Anat. Section Abstract Doc Link 17695985 Disease Relevance 0.76 Pain Relevance 0.27
Including callus morphology and quality, there seemed to be no correlation between the gene expression of OC, IGF-1, collagen1?
Neg (no) Regulation (correlation) of Gene_expression (expression) of IGF-1
10) Confidence 0.37 Published 2008 Journal Langenbecks Arch Surg Section Body Doc Link PMC2814041 Disease Relevance 0.44 Pain Relevance 0
Kainic acid up-regulated the expression of the inflammatory cytokines IL-1beta and TNF-alpha, the neurotrophic factor IGF-1, and the transcription factor NF-kappaB.
Regulation (regulated) of Gene_expression (expression) of IGF-1 associated with inflammation and cytokine
11) Confidence 0.36 Published 2008 Journal Nutr Neurosci Section Abstract Doc Link 18681986 Disease Relevance 0.70 Pain Relevance 0.53
There is a significant down-regulation in the expression of IGF-I and IGF-IR in the small DRG neurons of STZ rats by 59% and 71%, respectively.
Regulation (regulation) of Gene_expression (expression) of IGF-I in neurons
12) Confidence 0.27 Published 2002 Journal Neuroreport Section Abstract Doc Link 12352620 Disease Relevance 0.26 Pain Relevance 0.22
For instance, it is well established that microgravity or simulated microgravity disrupts pituitary GH function [58-60] and alters IGF-I expression and plasma concentration [60,63].
Regulation (alters) of Gene_expression (expression) of IGF-I in plasma
13) Confidence 0.25 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1851714 Disease Relevance 0.15 Pain Relevance 0.04
Circulating levels of IGF-I and of the insulin-like growth factor binding protein-I (IGFBP-I) are exquisitely sensitive to provision of nutrients, the former being increased and the latter being suppressed by food intake [9].
Regulation (sensitive) of Gene_expression (levels) of IGF-I
14) Confidence 0.21 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.30 Pain Relevance 0.23
Yet, gene expression of insulin-like growth factor-1 (IGF-1), a potent anabolic hormone, was down-regulated in skeletal muscles from tumor bearing rats [8].
Regulation (regulated) of Gene_expression (expression) of insulin-like growth factor-1 in skeletal muscles associated with cancer
15) Confidence 0.20 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1950512 Disease Relevance 0.51 Pain Relevance 0.06
Yet, gene expression of insulin-like growth factor-1 (IGF-1), a potent anabolic hormone, was down-regulated in skeletal muscles from tumor bearing rats [8].
Regulation (regulated) of Gene_expression (expression) of IGF-1 in skeletal muscles associated with cancer
16) Confidence 0.20 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1950512 Disease Relevance 0.51 Pain Relevance 0.06
Effects of capsaicin and isoflavone on blood pressure and serum levels of insulin-like growth factor-I in normotensive and hypertensive volunteers with alopecia.
Regulation (Effects) of Gene_expression (levels) of insulin-like growth factor-I in blood associated with qutenza, hypertension and alopecia
17) Confidence 0.19 Published 2009 Journal Biosci. Biotechnol. Biochem. Section Title Doc Link 19502719 Disease Relevance 0.65 Pain Relevance 0.71
on the expression of several neurotrophic factors such as NGF, IGF-1, and NT-3
Regulation (on) of Gene_expression (expression) of IGF-1 associated with nerve growth factor
18) Confidence 0.18 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2323445 Disease Relevance 0.55 Pain Relevance 0.28

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