INT105538

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Context Info
Confidence 0.56
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 12.51
Pain Relevance 5.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnfrsf1a) extracellular space (Tnfrsf1a) extracellular region (Tnfrsf1a)
plasma membrane (Tnfrsf1a) nucleus (Tnfrsf1a) protein complex (Tnfrsf1a)
Anatomy Link Frequency
blood 1
liver 1
neurons 1
cleavage 1
Tnfrsf1a (Mus musculus)
Pain Link Frequency Relevance Heat
allodynia 2 99.82 Very High Very High Very High
Multiple sclerosis 57 98.96 Very High Very High Very High
dorsal root ganglion 50 98.88 Very High Very High Very High
Paracetamol 24 98.38 Very High Very High Very High
Thermal hyperalgesia 3 98.30 Very High Very High Very High
qutenza 61 97.76 Very High Very High Very High
Inflammation 169 97.32 Very High Very High Very High
abdominal pain 3 95.52 Very High Very High Very High
Sciatic nerve 2 94.80 High High
Eae 1 93.72 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 76 100.00 Very High Very High Very High
Cancer 33 100.00 Very High Very High Very High
Necrosis 31 100.00 Very High Very High Very High
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 137 99.92 Very High Very High Very High
Disease 194 99.84 Very High Very High Very High
Neuropathic Pain 3 99.82 Very High Very High Very High
Demyelinating Disease 72 98.96 Very High Very High Very High
Ganglion Cysts 51 98.88 Very High Very High Very High
Hyperalgesia 12 98.30 Very High Very High Very High
INFLAMMATION 189 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A third hypothesis is that TNFR1 mutations in TRAPS cause impaired cleavage of membrane-bound TNFR1, leading to reduced serum levels of soluble TNFR1.
Negative_regulation (reduced) of TNFR1 in cleavage associated with tumor necrosis factor receptor-associated periodic syndrome
1) Confidence 0.56 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206363 Disease Relevance 0.42 Pain Relevance 0.06
Other TACE inhibitors including BMS-561392 have been delayed from clinical trials due to the potential risk of hepatoxicity resulting from the accumulation of tmTNF and the inhibition of TNFR1 and TNFR2 shedding which was demonstrated in rats treated with TACE inhibitors (reviewed in [121]).


Negative_regulation (inhibition) of TNFR1
2) Confidence 0.44 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 0.71 Pain Relevance 0.39
This hypothesis was supported by initial observations that some TRAPS patient cells are resistant to phorbol-myristate acetate-induced 'shedding' of TNFR1 from the surface, and that serum from TRAPS patients contained reduced levels of circulating soluble TNFR1, relative to controls [13].
Negative_regulation (reduced) of TNFR1 associated with tumor necrosis factor receptor-associated periodic syndrome
3) Confidence 0.41 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206363 Disease Relevance 0.36 Pain Relevance 0.06
Significantly decreased TNFR1 staining was also found in DRG neurons of the PBN plus resiniferatoxin treated group (11.08 ± 1.39%, n = 534, P < 0.01) compared that with resiniferatoxin treated group (16.5 ± 1.37%) (Fig. 3B).


Negative_regulation (decreased) of TNFR1 in neurons associated with dorsal root ganglion
4) Confidence 0.41 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.62 Pain Relevance 1.10
Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the role of TNF-alpha in pro- and anti-inflammatory mediator production and liver injury induced by acetaminophen.
Negative_regulation (disruption) of TNFR1 in liver associated with targeted disruption, necrosis, paracetamol, inflammation, cancer and injury
5) Confidence 0.41 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14550746 Disease Relevance 1.08 Pain Relevance 0.43
Acetaminophen-induced expression of MCP-1, IL-1beta, CTGF, and MMP-9 mRNA was also delayed or reduced in TNFR1(-/-) mice relative to wild-type mice.
Negative_regulation (reduced) of TNFR1 associated with paracetamol
6) Confidence 0.40 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14550746 Disease Relevance 0.86 Pain Relevance 0.82
We found an absence of thermal hyperalgesia in mice deficient of TNFR1 and a reduction in mechanical and cold allodynia in mice deficient of TNFR1 or TNFR2 compared with wild-type mice.
Negative_regulation (deficient) of TNFR1 associated with allodynia and thermal hyperalgesia
7) Confidence 0.40 Published 2006 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 17117937 Disease Relevance 1.03 Pain Relevance 0.77
Defective shedding of TNFRSF1A can only partially explain the pathophysiologic mechanism of TRAPS, since some mutations have normal shedding.
Negative_regulation (Defective) of TNFRSF1A associated with tumor necrosis factor receptor-associated periodic syndrome
8) Confidence 0.37 Published 2002 Journal Medicine (Baltimore) Section Abstract Doc Link 12352631 Disease Relevance 1.14 Pain Relevance 0.13
Absence of TNFR1 was associated with decreased levels of secreted TNF-?
Negative_regulation (Absence) of TNFR1
9) Confidence 0.34 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3017519 Disease Relevance 1.07 Pain Relevance 0.48
Lastly, TNFR1 polymorphisms TNFR1-609 and TNFRI+36 have been found to be significantly decreased in PD patients [156].
Negative_regulation (decreased) of TNFR1 associated with disease
10) Confidence 0.32 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 1.11 Pain Relevance 0.05
Experiments to block solTNF/TNFR1 signaling with the solTNF-selective DN-TNF inhibitors in the cuprizone model should yield further support for this hypothesis.
Negative_regulation (block) of TNFR1
11) Confidence 0.32 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 0.79 Pain Relevance 0.28
Mice with complete inactivation of TNF or TNFR1 gene are unable to mount a protective response against various pathogens [15], but develop ECM, while TNFR2 deficient mice are resistant to ECM development [16].
Negative_regulation (inactivation) of TNFR1 associated with cerebral malaria
12) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2442868 Disease Relevance 0.91 Pain Relevance 0.09
The gene expression of all molecules except for IFN-gamma and iNOS was significantly attenuated in TNF-Rp55-KO mice.
Negative_regulation (attenuated) of TNF-Rp55-KO associated with targeted disruption
13) Confidence 0.24 Published 2004 Journal J. Leukoc. Biol. Section Abstract Doc Link 14557383 Disease Relevance 1.18 Pain Relevance 0.76
Increasing prealbumin correlated with reduction in TNFR-p55 and TNFR-p75 (Yeh et al 2000b, 2001).
Negative_regulation (reduction) of TNFR-p55
14) Confidence 0.01 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676640 Disease Relevance 1.02 Pain Relevance 0.19
This group consisted of 12 children with TNF level higher and the tendency toward decrease in sTNFRI was established, 3 hours since headache started, as compared to 18/30 children with migraine but without increase in IL-6.
Negative_regulation (decrease) of sTNFRI
15) Confidence 0.00 Published 2005 Journal Prz. Lek. Section Body Doc Link 16512619 Disease Relevance 0 Pain Relevance 0
RESULTS: In patients with RA under general anesthesia, the levels of IL-6, TNF-alpha, and TNF-R1 and TNF-R2 in the peripheral blood were significantly decreased compared with the levels before anesthesia (p < 0.01).
Negative_regulation (decreased) of TNF-R1 in blood
16) Confidence 0.00 Published 2004 Journal Clin. Exp. Rheumatol. Section Body Doc Link 15638047 Disease Relevance 0.20 Pain Relevance 0

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