INT105551

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Context Info
Confidence 0.69
First Reported 2002
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 4.21
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Tnfsf11) extracellular space (Tnfsf11) extracellular region (Tnfsf11)
plasma membrane (Tnfsf11) intracellular (Tnfsf11) cytoplasm (Tnfsf11)
Anatomy Link Frequency
MC3T3-E1 2
teeth 2
joints 1
synovial cells 1
Tnfsf11 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 108 98.52 Very High Very High Very High
cytokine 81 81.68 Quite High
Pain 7 80.20 Quite High
Inflammation 50 75.00 Quite High
Inflammatory response 3 73.60 Quite High
Inflammatory mediators 8 36.48 Quite Low
rheumatoid arthritis 66 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
Freund adjuvant 4 5.00 Very Low Very Low Very Low
Peripheral nervous system 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 128 98.52 Very High Very High Very High
Temporomandibular Joint Syndrome 1 93.80 High High
Osteoporosis 28 86.64 High High
Hypercalcemia 22 82.88 Quite High
Tooth Loss 3 82.48 Quite High
Disease 7 80.24 Quite High
Pain 5 80.20 Quite High
INFLAMMATION 61 75.00 Quite High
Cancer 6 51.76 Quite High
Necrosis 6 51.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of receptor activator nuclear factor kappaB ligand (RANKL) mRNA and protein in synovial cells was analyzed by reverse transcriptase-polymerase chain reaction, immunoblotting, and immunofluorescence staining.
Spec (analyzed) Transcription (expression) of RANKL in synovial cells
1) Confidence 0.69 Published 2007 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 17321443 Disease Relevance 0.09 Pain Relevance 0
U0126 (a MEK1/2 inhibitor) or LY294002 (a PI3K inhibitor) was added to ST2 and MC3T3-E1 cells, and was found to inhibit RANKL mRNA and RANKL protein expression in these cells.
Transcription (expression) of RANKL protein in MC3T3-E1
2) Confidence 0.68 Published 2007 Journal Mol. Cell. Biochem. Section Abstract Doc Link 17549607 Disease Relevance 0.36 Pain Relevance 0.04
U0126 (a MEK1/2 inhibitor) or LY294002 (a PI3K inhibitor) was added to ST2 and MC3T3-E1 cells, and was found to inhibit RANKL mRNA and RANKL protein expression in these cells.
Transcription (expression) of RANKL mRNA in MC3T3-E1
3) Confidence 0.68 Published 2007 Journal Mol. Cell. Biochem. Section Abstract Doc Link 17549607 Disease Relevance 0.41 Pain Relevance 0.04
The mRNA expression of RANK and RANKL was heavily stimulated in joints after CIA induction (Fig. 3a).
Transcription (expression) of RANKL in joints associated with arthritis
4) Confidence 0.36 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 1.16 Pain Relevance 0.50
However, OPG mRNA expression was higher in gingival tissue associated with teeth affected with FORL than in normal gingival tissue (P<0.05), whereas the reverse was true of RANKL mRNA expression (P<0.05).
Transcription (expression) of OPG in teeth
5) Confidence 0.36 Published 2002 Journal J. Comp. Pathol. Section Abstract Doc Link 12354528 Disease Relevance 0.37 Pain Relevance 0.12
OPG mRNA expression was significantly higher in teeth than in femoral and alveolar bone (P<0.001).
Transcription (expression) of OPG in teeth
6) Confidence 0.36 Published 2002 Journal J. Comp. Pathol. Section Abstract Doc Link 12354528 Disease Relevance 0.43 Pain Relevance 0.14
RANKL and OPG mRNAs were detected in all tissues examined.
Transcription (detected) of OPG
7) Confidence 0.36 Published 2002 Journal J. Comp. Pathol. Section Abstract Doc Link 12354528 Disease Relevance 0.43 Pain Relevance 0.14
Although in VIP treated mice OPG mRNA levels were slightly increased, a seven-fold drop in the RANKL/OPG ratio was observed (Table 3).
Transcription (levels) of OPG
8) Confidence 0.31 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 0.96 Pain Relevance 0.40

General Comments

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