INT10556

Context Info Confidence 0.44 First Reported 1981 Last Reported 1996 Negated 2 Speculated 6 Reported most in Abstract Documents 5 Total Number 11 Disease Relevance 0.51 Pain Relevance 2.80

lipid binding (Apoa2) protein folding (Apoa2) transport (Apoa2) extracellular space (Apoa2) extracellular region (Apoa2) cellular_component (Apoa2)

Anatomy Link Frequency hypothalamus 1 sympathetic 1 skin 1 brainstem 1 heart 1 Apoa2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat antagonist 15 100.00 anesthesia 12 100.00 Intracerebroventricular 10 100.00 agonist 9 99.32 Neuropeptide 1 99.04 Clonidine 6 98.68 medulla 2 96.72 Catecholamine 1 96.56 local anesthetic 1 89.36 tetrodotoxin 2 83.84

Disease Link Frequency Relevance Heat Wound Healing 2 99.28 Poisoning 4 97.68 Endotoxemia 2 73.12 Hypotension 1 69.20 Shock 2 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Effects of intracerebroventricular (i. c. v.) administration of angiotensin II (AII) on renal sympathetic nerve activity (RSNA), arterial pressure, and heart rate were examined in rats anesthetized with a mixture of urethane and alpha-chloralose.

Spec (examined) Regulation (Effects) of AII in sympathetic associated with intracerebroventricular

1) Confidence 0.44 Published 1989 Journal J. UOEH Section Abstract Doc Link 2609034 Disease Relevance 0 Pain Relevance 0.12

The purpose of the present study was to determine the effects of an angiotensin II (AII) AT1 antagonist, losartan 10, 15, and 20 mg/kg IP, and the AII AT2 antagonist, PD 123319, 20 mg/kg IP on ethanol (EtOH) intoxication as measured by the aerial righting reflex in male rats.

Spec (determine) Regulation (effects) of AII associated with antagonist and poisoning

2) Confidence 0.43 Published 1996 Journal Alcohol Section Abstract Doc Link 8734844 Disease Relevance 0.10 Pain Relevance 0.25

The purpose of the present study was to determine the effects of an angiotensin II (AII) AT1 antagonist, losartan 10, 15, and 20 mg/kg IP, and the AII AT2 antagonist, PD 123319, 20 mg/kg IP on ethanol (EtOH) intoxication as measured by the aerial righting reflex in male rats.

Spec (determine) Regulation (effects) of AII associated with antagonist and poisoning

3) Confidence 0.43 Published 1996 Journal Alcohol Section Abstract Doc Link 8734844 Disease Relevance 0.10 Pain Relevance 0.26

The results show that the periventricular alpha 1-adrenoceptors are involved only in the cardiovascular responses produced by central AII, whereas clonidine acting through alpha 2-adrenergic and/or imidazole receptors can modulate all actions of AII.

Regulation (modulate) of AII associated with clonidine

4) Confidence 0.37 Published 1990 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2171000 Disease Relevance 0 Pain Relevance 0.45

Here we have determined changes in skin AII receptors during wound healing in adult male Sprague-Dawley rats.

Spec (determined) Regulation (changes) of AII in skin associated with wound healing

5) Confidence 0.37 Published 1992 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 1530605 Disease Relevance 0.17 Pain Relevance 0.09

The effect of pentobarbital (PB) anesthesia on the pressor and heart rate (HR) dose responses to norepinephrine (NE), angiotensin II (AII), vasopressin (VP) and neuropeptide Y (NPY) was studied in vivo in normal and endotoxemic rats.

Regulation (effect) of AII in heart associated with anesthesia and neuropeptide

6) Confidence 0.26 Published 1995 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 8747796 Disease Relevance 0.14 Pain Relevance 0.58

The effects of angiotensin II (AII) given intracerebroventricularly (icv.) on behaviors controlled by central serotonine (5-HT) and on some neurochemical measures of central 5-HT function have been investigated in rats.

Regulation (effects) of AII

7) Confidence 0.26 Published 1985 Journal Biomed. Biochim. Acta Section Abstract Doc Link 3878708 Disease Relevance 0 Pain Relevance 0.07

In this study we have used whole-cell, voltage-clamp procedures to determine the effects of angiotensin II (AII) on net outward current (I(no)) in neurons co-cultured from the hypothalamus and brainstem of 1-day-old rats.

Spec (determine) Regulation (effects) of AII in brainstem associated with medulla

8) Confidence 0.25 Published 1992 Journal Brain Res. Section Abstract Doc Link 1504808 Disease Relevance 0 Pain Relevance 0.20

In contrast, the potentiation of NE responses by AII was unaffected by propranolol.

Neg (unaffected) Regulation (unaffected) of AII

9) Confidence 0.22 Published 1981 Journal Hypertension Section Abstract Doc Link 6259059 Disease Relevance 0 Pain Relevance 0.09

Prazosin produced no alteration in the dipsogenic effect of AII.

Neg (no) Regulation (alteration) of AII

10) Confidence 0.22 Published 1990 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2171000 Disease Relevance 0 Pain Relevance 0.49

In this study we have used whole-cell, voltage-clamp procedures to determine the effects of angiotensin II (AII) on net outward current (I(no)) in neurons co-cultured from the hypothalamus and brainstem of 1-day-old rats.

Spec (determine) Regulation (effects) of AII in hypothalamus associated with medulla

11) Confidence 0.08 Published 1992 Journal Brain Res. Section Abstract Doc Link 1504808 Disease Relevance 0 Pain Relevance 0.20

General Comments

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