INT105569

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Context Info
Confidence 0.25
First Reported 2002
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 17.31
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGFALS) extracellular space (IGFALS) extracellular region (IGFALS)
cell adhesion (IGFALS) nucleolus (IGFALS) nucleus (IGFALS)
Anatomy Link Frequency
thyroid 1
brain 1
IGFALS (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 16 99.80 Very High Very High Very High
Migraine 40 96.96 Very High Very High Very High
cva 9 95.76 Very High Very High Very High
sSRI 8 95.60 Very High Very High Very High
headache 17 93.80 High High
Inflammation 27 91.12 High High
Analgesic 2 85.32 High High
antidepressant 1 80.40 Quite High
Central nervous system 42 58.04 Quite High
palliative 9 57.52 Quite High
Disease Link Frequency Relevance Heat
Motor Neuron Diseases 903 100.00 Very High Very High Very High
Hyponatremia 4 99.82 Very High Very High Very High
Demyelinating Disease 20 99.80 Very High Very High Very High
Cancer 33 99.76 Very High Very High Very High
Nicotine Addiction 13 99.66 Very High Very High Very High
Disease 334 99.40 Very High Very High Very High
Conversion Disorder 2 98.70 Very High Very High Very High
Syndrome 69 98.66 Very High Very High Very High
Spinal Cord Diseases 14 97.88 Very High Very High Very High
Migraine With Aura 2 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is worth noting that IGF-1 usually complexes with IGFBP-3 and ALS that depend on GH level and action.
ALS Binding (complexes) of
1) Confidence 0.25 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724186 Disease Relevance 0 Pain Relevance 0
Thus our case does not support the hypothesis that ALS in associated with cancer and the relationship between both disorders remains uncertain.
ALS Binding (associated) of associated with cancer and motor neuron diseases
2) Confidence 0.25 Published 2007 Journal Nippon Shokakibyo Gakkai Zasshi Section Abstract Doc Link 17827908 Disease Relevance 1.53 Pain Relevance 0.06
Recent reviews on the role of environmental risk factors in the causation of ALS have concluded that there is no consistent association between a single environmental factor and risk of developing ALS.
ALS Neg (no) Binding (association) of associated with motor neuron diseases
3) Confidence 0.20 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2656493 Disease Relevance 2.14 Pain Relevance 0
By applying an evidenced based approach, it was found that only smoking is likely to be associated with developing ALS, while other risk factors were weakly related.
ALS Spec (likely) Binding (associated) of associated with nicotine addiction and motor neuron diseases
4) Confidence 0.20 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2656493 Disease Relevance 1.91 Pain Relevance 0
Merlini et al. [13] reported on three patients with ALS, two of whom had an IgG monoclonal protein and one with biclonal gammopathy (IgG?
ALS Binding (two) of associated with motor neuron diseases
5) Confidence 0.19 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2941760 Disease Relevance 1.43 Pain Relevance 0
However, Rodriguez et al. [19] reported on a series of patients diagnosed with ALS and concluded that there was no pathogenic association between thyroid dysfunction or alteration of phosphate calcium metabolism and ALS.
ALS Neg (no) Binding (association) of in thyroid associated with motor neuron diseases
6) Confidence 0.18 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2941760 Disease Relevance 1.85 Pain Relevance 0
It has been reported that syndrome of inappropriate secretion of antidiuretic hormone (SIADH) may be associated with ALS.
ALS Binding (associated) of associated with hyponatremia, syndrome and motor neuron diseases
7) Confidence 0.18 Published 2002 Journal Rinsho Shinkeigaku Section Abstract Doc Link 12355854 Disease Relevance 1.12 Pain Relevance 0.91
We observed no association between mobile phone use and ALS, which is reassuring, as this disease has been reported to be associated with occupational exposure to ELF-EMF [10], [11].
ALS Neg (no) Binding (association) of associated with disease and motor neuron diseases
8) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2632742 Disease Relevance 0.92 Pain Relevance 0.11
The objective of this study was to use quantitative ELISA to further evaluate the utility of cystatin C as a biomarker for ALS using a large subject population.
ALS Binding (biomarker) of associated with motor neuron diseases
9) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 1.24 Pain Relevance 0
The disease control group included six patients with multiple sclerosis, one with bilateral facial palsies, one with neurosarcoidosis, one with viral encephalitis, one with CNS lymphoma, one with brain metastases, one with pseudotumor cerebri, one with a seizure disorder, one with complicated migraine, one with paresthesis and possible myelopathy, one with a probable conversion disorder, and nine with neurologic diseases that can clinically resemble ALS at presentation.
ALS Binding (presentation) of in brain associated with migraine, disease, motor neuron diseases, metastasis, spinal cord diseases, epilepsy, multiple sclerosis, lymphatic system cancer, conversion disorder, migraine with aura, cva, encephalitis and facial paralysis
10) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 2.65 Pain Relevance 0.24
Kaplan–Meier survival curves from patients with fALS-causing SOD1 mutations, non-SOD1-related fALS, and sALS were generated.
fALS Binding (generated) of
11) Confidence 0.14 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2486295 Disease Relevance 0.43 Pain Relevance 0
One of these genes encoding Cu/Zn-superoxide dismutase (SOD1) was found to associate with 20% of fALS, and at least 119 fALS-associated SOD1 mutations have been characterized in humans [1,5].
fALS Binding (associate) of
12) Confidence 0.13 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2486295 Disease Relevance 0.70 Pain Relevance 0
We found no association between mobile phones use and ALS and multiple sclerosis.
ALS Neg (no) Binding (association) of associated with multiple sclerosis and motor neuron diseases
13) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2632742 Disease Relevance 0.83 Pain Relevance 0.05
Long-standing associations of some forms of ALS with mutations in genes coding for superoxide dismutase 1 (e.g.
ALS Binding (associations) of
14) Confidence 0.03 Published 2010 Journal Arch Toxicol Section Body Doc Link PMC2988997 Disease Relevance 0.56 Pain Relevance 0
At multivariate analysis, ICD remained associated with both IGF-1 (beta-coefficient=0.513, P<0.001), and ALS (beta-coefficient=0.645, P<0.001), after correction for confounding factors.
ALS Binding (associated) of
15) Confidence 0.02 Published 2009 Journal Int Angiol Section Body Doc Link 19506539 Disease Relevance 0 Pain Relevance 0

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