INT10557

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Context Info
Confidence 0.62
First Reported 1970
Last Reported 1999
Negated 7
Speculated 3
Reported most in Abstract
Documents 13
Total Number 16
Disease Relevance 2.76
Pain Relevance 9.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 4
dorsal 2
pituitary 2
neural 2
LH (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 72 100.00 Very High Very High Very High
Morphine 29 100.00 Very High Very High Very High
opiate 20 100.00 Very High Very High Very High
antagonist 13 100.00 Very High Very High Very High
opioid receptor 6 100.00 Very High Very High Very High
Opioid 17 99.98 Very High Very High Very High
Nicotine 9 99.84 Very High Very High Very High
Clonidine 1 99.82 Very High Very High Very High
analgesia 13 99.80 Very High Very High Very High
Raphe 3 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 15 100.00 Very High Very High Very High
Body Weight 5 100.00 Very High Very High Very High
Uremia 9 99.84 Very High Very High Very High
Galactorrhea 1 94.88 High High
Exsanguination 2 93.20 High High
Shock 1 86.32 High High
Pain 1 82.72 Quite High
Reprotox - General 2 1 75.00 Quite High
Urological Neuroanatomy 3 74.08 Quite High
Opiate Addiction 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clonidine induced increases in serum LH were not altered by nicotine treatment and haloperidol treatment did not alter nicotine induced decreases in serum LH.
Neg (not) Regulation (altered) of Positive_regulation (increases) of LH associated with nicotine and clonidine
1) Confidence 0.62 Published 1997 Journal Life Sci. Section Abstract Doc Link 9194685 Disease Relevance 0 Pain Relevance 0.67
In marked contrast to these results, castration did not significantly affect naloxone-induced increases in serum LH levels.
Neg (not) Regulation (affect) of Positive_regulation (increases) of serum LH associated with narcan
2) Confidence 0.53 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7143239 Disease Relevance 0 Pain Relevance 1.30
Plasma LH was not affected by stress, but 30 min after naloxone (1 or 10 mg/kg BW) injection, LH was elevated in both control and stressed rats above levels in vehicle-injected animals.
Neg (not) Regulation (affected) of Positive_regulation (elevated) of LH in Plasma associated with stress, body weight and narcan
3) Confidence 0.45 Published 1994 Journal Neuroendocrinology Section Abstract Doc Link 8202214 Disease Relevance 1.13 Pain Relevance 0.54
In contrast to females, estrogen-primed male rats did not display either an increase in serum LH or an enhancement of the alpha-methyltyrosine-induced decline of NE or E after treatment with naloxone.
Neg (not) Regulation (display) of Positive_regulation (increase) of LH associated with narcan
4) Confidence 0.41 Published 1988 Journal Brain Res. Section Abstract Doc Link 3052697 Disease Relevance 0 Pain Relevance 0.53
Administration of naloxone (2 mg/kg, iv) to cannulated freely mobile rats confirmed previous observations that despite marked increases in plasma LH in control rats, plasma LH levels were unaffected in uremic male rats (P = 0.001 for group x time interaction).
Neg (unaffected) Regulation (unaffected) of Positive_regulation (increases) of LH in plasma associated with narcan and uremia
5) Confidence 0.39 Published 1990 Journal Endocrinology Section Abstract Doc Link 2137774 Disease Relevance 0.49 Pain Relevance 0.52
In control animals (saline), there was a marked fall in LH levels and a large increase in prolactin levels within 15 min of suckling.
Regulation (fall) of Positive_regulation (increase) of LH
6) Confidence 0.37 Published 1984 Journal J. Endocrinol. Section Abstract Doc Link 6420492 Disease Relevance 0 Pain Relevance 0.38
To address this hypothesis, we investigated the effects of various opioid receptor antagonists on suckling-induced prolactin (PRL) and LH responses in primiparous, lactating rats.
Spec (investigated) Regulation (effects) of Spec (investigated) Positive_regulation (suckling-induced) of LH associated with antagonist and opioid receptor
7) Confidence 0.37 Published 1991 Journal Brain Res. Section Abstract Doc Link 1667901 Disease Relevance 0.09 Pain Relevance 0.51
It was found that beta-EP blocked the preovulatory surge of LH release and ovulation, while it did not affect LH release in response to LH-RH injection.
Neg (not) Regulation (affect) of Positive_regulation (response) of LH
8) Confidence 0.36 Published 1983 Journal Endocrinol. Jpn. Section Abstract Doc Link 6319110 Disease Relevance 0.21 Pain Relevance 0.07
Radioimmunoassay of all 3 hormones indicated that the increases in serum LH and prolactin did not necessarily occur simultaneously.
Neg (not) Regulation (occur) of Positive_regulation (increases) of LH
9) Confidence 0.32 Published 1970 Journal Fed. Proc. Section Abstract Doc Link 5529888 Disease Relevance 0.17 Pain Relevance 0.17
In the present study, we investigated the role of opiates in the induction of LH and SIA under different conditions.
Spec (investigated) Regulation (role) of Spec (investigated) Positive_regulation (induction) of LH associated with opiate and analgesia
10) Confidence 0.27 Published 1997 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 9292116 Disease Relevance 0.27 Pain Relevance 1.12
Recent studies show that a decrease in hypothalamic inhibitory opioid tone by the neural clock (NC) is responsible for the induction of the preovulatory LH surge on proestrus.
Regulation (responsible) of Positive_regulation (induction) of LH in neural associated with opioid
11) Confidence 0.27 Published 1990 Journal Endocrinology Section Abstract Doc Link 2293982 Disease Relevance 0 Pain Relevance 0.58
Conversely LHRH was most effective in increasing LH levels on the day of pro-oestrus and in OB-treated rats.
Regulation (effective) of Positive_regulation (increasing) of LH
12) Confidence 0.27 Published 1986 Journal J. Endocrinol. Section Abstract Doc Link 3003224 Disease Relevance 0 Pain Relevance 0.38
The effects of morphine pretreatment on naloxone-induced increases in serum luteinizing hormone (LH) levels were examined in male rats.
Regulation (effects) of Spec (examined) Positive_regulation (increases) of LH associated with narcan and morphine
13) Confidence 0.27 Published 1983 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6682144 Disease Relevance 0 Pain Relevance 0.65
Thus, endogenous opiates clearly participate in the initial induction of LH and SIA and, although the degree of endogenous opiate involvement in the subsequent expression of these behaviors is unclear, it seems evident that their expression can occur in the presence of opiate antagonism and may therefore require the participation of additional transmitter systems.
Regulation (participate) of Positive_regulation (induction) of LH associated with opiate and analgesia
14) Confidence 0.26 Published 1987 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 3124164 Disease Relevance 0.40 Pain Relevance 1.33
Evidence that long-term estrogen treatment disrupts opioid involvement in the induction of pituitary LH surge.
Regulation (involvement) of Positive_regulation (induction) of LH in pituitary associated with narcan and opioid
15) Confidence 0.24 Published 1992 Journal Brain Res. Section Title Doc Link 1504826 Disease Relevance 0 Pain Relevance 0.49
These results suggest that the dorsal raphe nucleus plays an important role in induction of LH surge and ovulation and the 5-HT 2A/2C receptor system is involved in this mechanism.
Regulation (role) of Positive_regulation (induction) of LH in dorsal associated with raphe
16) Confidence 0.22 Published 1999 Journal Neurosci. Res. Section Abstract Doc Link 10617320 Disease Relevance 0 Pain Relevance 0.37

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