INT10558

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Context Info
Confidence 0.45
First Reported 1991
Last Reported 2009
Negated 1
Speculated 2
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 4.94
Pain Relevance 2.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6) aging (IL6) extracellular region (IL6)
Anatomy Link Frequency
monocytes 2
muscle 2
neurons 2
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 101 100.00 Very High Very High Very High
cytokine 61 100.00 Very High Very High Very High
anesthesia 3 99.78 Very High Very High Very High
antagonist 3 99.68 Very High Very High Very High
opioid receptor 1 99.46 Very High Very High Very High
Versed 2 99.28 Very High Very High Very High
qutenza 6 98.60 Very High Very High Very High
narcan 6 98.38 Very High Very High Very High
Pain 10 96.96 Very High Very High Very High
corticosteroid 1 81.96 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 129 100.00 Very High Very High Very High
Disease 41 100.00 Very High Very High Very High
Cancer 36 100.00 Very High Very High Very High
Necrosis 8 100.00 Very High Very High Very High
Keloid Scars 103 99.58 Very High Very High Very High
Anxiety Disorder 1 97.96 Very High Very High Very High
Blister 23 97.20 Very High Very High Very High
Pain 7 96.96 Very High Very High Very High
Muscular Atrophy 1 92.40 High High
Stress 6 89.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Group assignment did not differentially affect change in IL-6 over time, either before or after capsaicin.
Neg (not) Regulation (affect) of Regulation (change) of IL-6 associated with qutenza
1) Confidence 0.45 Published 2004 Journal Brain Behav. Immun. Section Abstract Doc Link 14651947 Disease Relevance 0.72 Pain Relevance 0.57
However, whether changes in IL-6 concentration can influence human muscle SC function has yet to be examined.
Regulation (influence) of Regulation (changes) of IL-6 in muscle
2) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.58 Pain Relevance 0.11
This study was undertaken to determine whether hrIL-6 affects the single-unit activity of thermosensitive and thermally insensitive neurons in hypothalamic tissue slices and whether indomethacin (Indo) or naloxone (Nal), a cyclooxygenase inhibitor and a mu-opioid receptor antagonist, respectively, influences the effects of hrIL-6 on those neurons. hrIL-6 (2 x 10(3)-8 x 10(3) U/ml) depressed the activity in 50 (83%) of 60 warm-sensitive (W) neurons and excited all 4 cold-sensitive (C) neurons found.
Spec (whether) Regulation (influences) of Spec (whether) Regulation (effects) of hrIL-6 in neurons associated with antagonist, narcan and opioid receptor
3) Confidence 0.39 Published 1992 Journal Brain Res. Bull. Section Abstract Doc Link 1504850 Disease Relevance 0.09 Pain Relevance 0.29
Further studies are needed to determine whether the anti-scarring effect of the intralesional steroid therapy in keloid scar correlates with its role on the regulation of the IL-17/IL-6.
Spec (whether) Regulation (role) of Regulation (regulation) of IL-6 associated with keloid scars
4) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 1.24 Pain Relevance 0.09
In order to determine the contribution of pro-inflammatory cytokines to the disease activity, both IL-6 and TNF-?
Regulation (determine) of Regulation (contribution) of IL-6 associated with inflammation, disease and cytokine
5) Confidence 0.29 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1693561 Disease Relevance 0.70 Pain Relevance 0.24
Benzodiazepine anesthesia in humans modulates the interleukin-1 beta, tumor necrosis factor-alpha and interleukin-6 responses of blood monocytes.
Regulation (modulates) of Regulation (responses) of interleukin-6 in monocytes associated with necrosis, anesthesia and cancer
6) Confidence 0.27 Published 1991 Journal J. Neuroimmunol. Section Title Doc Link 1955561 Disease Relevance 0.47 Pain Relevance 0.47
Quercetin inhibits inflammatory reactions by regulating the generation of inflammatory cytokines such as IL-6, TNF-?
Regulation (regulating) of Regulation (generation) of IL-6 associated with inflammation and cytokine
7) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374451 Disease Relevance 1.16 Pain Relevance 0.55

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