INT10559

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Context Info
Confidence 0.37
First Reported 1992
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.76
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6) aging (IL6) extracellular region (IL6)
Anatomy Link Frequency
neurons 4
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 12 99.50 Very High Very High Very High
antagonist 2 83.84 Quite High
opioid receptor 2 83.40 Quite High
cytokine 65 82.36 Quite High
Inflammation 15 75.00 Quite High
Opioid 2 71.04 Quite High
palliative 1 66.44 Quite High
Inflammatory mediators 8 46.08 Quite Low
anesthesia 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 11 99.20 Very High Very High Very High
Lung Cancer 16 89.92 High High
Leukemia 4 84.88 Quite High
Fever 4 78.08 Quite High
INFLAMMATION 23 75.00 Quite High
Carcinoma 16 70.40 Quite High
Salivary Gland Disease 1 64.84 Quite High
Frailty 1 63.92 Quite High
Autoimmune Disease 1 58.24 Quite High
Metaplasia 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nal(0.1-1 mg/ml) blocked or reduced the effect of hrIL-6 on 21 of 25 W neurons and 1 C neuron recorded.
Negative_regulation (reduced) of Regulation (effect) of hrIL-6 in neurons associated with narcan
1) Confidence 0.37 Published 1992 Journal Brain Res. Bull. Section Abstract Doc Link 1504850 Disease Relevance 0.14 Pain Relevance 0.36
Indo (0.05-1 mg/ml) blocked the effect of hrIL-6 on 22 of 24 W neurons and 2 C neurons tested.
Negative_regulation (blocked) of Regulation (effect) of hrIL-6 in neurons
2) Confidence 0.37 Published 1992 Journal Brain Res. Bull. Section Abstract Doc Link 1504850 Disease Relevance 0.14 Pain Relevance 0.36
In preneoplastic cells, the aberrant signaling that was detected most frequently was an elevated activation of ERK, a reduced or increased IL-6 and EGF response, and an increased LIF response.
Negative_regulation (reduced) of Regulation (response) of IL-6
3) Confidence 0.27 Published 2005 Journal BMC Cancer Section Abstract Doc Link PMC1289280 Disease Relevance 0.51 Pain Relevance 0.13
In addition, the study assessed salivary IL-6, IFN, and IL-2 concentrations among 18 Sjögren's syndrome patients before and after administration of IFN via the oral mucosal route.
Negative_regulation (assessed) of Regulation (concentrations) of IL-6 associated with syndrome
4) Confidence 0.06 Published 2001 Journal Clin Oral Investig Section Abstract Doc Link 11480812 Disease Relevance 0.96 Pain Relevance 0.25

General Comments

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