INT105598

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Context Info
Confidence 0.16
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 11.83
Pain Relevance 2.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mtpn) nucleus (Mtpn) cytoplasm (Mtpn)
Anatomy Link Frequency
neurons 3
brain 2
neuronal 1
endothelial cells 1
monocyte 1
Mtpn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 9 100.00 Very High Very High Very High
ischemia 7 99.92 Very High Very High Very High
withdrawal 11 99.84 Very High Very High Very High
Spinal cord 83 99.72 Very High Very High Very High
Neuropathic pain 6 97.64 Very High Very High Very High
intrathecal 2 94.80 High High
Glutamate 14 93.52 High High
opiate 1 89.12 High High
Morphine 5 88.80 High High
Pain 51 88.56 High High
Disease Link Frequency Relevance Heat
Cancer 85 100.00 Very High Very High Very High
Cv Unclassified Under Development 5 99.92 Very High Very High Very High
Apoptosis 706 99.78 Very High Very High Very High
Osteoporosis 1 99.54 Very High Very High Very High
Stress 173 99.52 Very High Very High Very High
Fever 3 99.52 Very High Very High Very High
Toxicity 72 99.36 Very High Very High Very High
Parkinson's Disease 38 99.14 Very High Very High Very High
Hypercalcemia 5 98.96 Very High Very High Very High
Disease 611 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Osteoclastic expansion is reduced (inhibitor of tumor growth factor) and differentiation of macrophage – monocyte precursors is impeded (Coleman 1991; Warrel 1992; Rogers et al 1997; Major et al 2000).
Negative_regulation (inhibitor) of tumor growth factor in monocyte associated with cancer and osteoporosis
1) Confidence 0.16 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770417 Disease Relevance 1.13 Pain Relevance 0.50
The chronicity of neuropathic pain is thought to be related to many neurochemical changes in the dorsal root ganglia (DRG) and spinal cord, including a reduction in the retrograde transport of nerve growth factor (NGF).
Negative_regulation (reduction) of growth factor in nerve associated with nerve growth factor, neuropathic pain and spinal cord
2) Confidence 0.06 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12907315 Disease Relevance 0.78 Pain Relevance 1.45
If substantiated, then rapid removal of IGF-1 from the brain reported herein may be the reason for the lesser effectiveness of this growth factor.


Negative_regulation (effectiveness) of growth factor in brain
3) Confidence 0.03 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1190198 Disease Relevance 0.10 Pain Relevance 0.15
The 40% CR females also showed a down-regulation in the vascular endothelial growth factor (VEGF) signaling pathway, which plays an essential role in angiogenesis and follicle development within the female reproductive tract [37]–[39].
Negative_regulation (regulation) of growth factor in female reproductive tract
4) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607546 Disease Relevance 0.13 Pain Relevance 0
Apoptosis of neurons is caused by growth factor deprivation, ischemia, hyperthermia, hypercalcemia, excitotoxin, and active free radicals (6, 7).
Negative_regulation (deprivation) of growth factor in neurons associated with ischemia, hypercalcemia, fever and apoptosis
5) Confidence 0.02 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2782166 Disease Relevance 1.74 Pain Relevance 0.17
We next utilized an in vitro culture system of NSPCs to evaluate the roles of Rho GTPases in the process of programmed cell death induced by growth factor deprivation.
Negative_regulation (deprivation) of growth factor associated with apoptosis
6) Confidence 0.02 Published 2009 Journal Mol Brain Section Body Doc Link PMC2789715 Disease Relevance 0.49 Pain Relevance 0.08
The model presented in Figure 4 indicates that mitochondria play a significant role in the amplification of the apoptotic processes initiated by growth factor deprivation, DD receptors activation (p75 and Fas), increased levels of intracellular Ca2+ linked to excitotoxicity and ROS accumulation in response to the many brain insults.

6.4.

Negative_regulation (deprivation) of growth factor in brain associated with apoptosis
7) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.37 Pain Relevance 0
Experimental evidence of cell death following NGF deprivation have been obtained in vitro, mainly in PC12 cells and sympathetic neurons, where apoptosis following growth factor deprivation occurs mainly through an intrinsic pathway activated upon a failure of the TrkA/PI3K/Akt signaling, followed by translocation of Bax to mitochondria and release of cytochrome C [138,139,156].
Negative_regulation (deprivation) of growth factor in neurons associated with apoptosis and death
8) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.51 Pain Relevance 0.07
Oxidative stress and mitochondrial dysfunction are common players in the apoptotic cascades leading to neuronal death in AD and are induced by all the known triggers, including growth factor deprivation and A?
Negative_regulation (deprivation) of growth factor in neuronal associated with parkinson's disease, stress, disease, apoptosis and death
9) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 1.30 Pain Relevance 0.04
In sympathetic neurons, following growth factor deprivation and failure of PI3K/Akt signaling, Bad is activated by dephosphorylation, dissociation from the molecular chaperone 14-3-3 and association with Bcl-XL.
Negative_regulation (deprivation) of growth factor in neurons
10) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.29 Pain Relevance 0
After thalidomide treatment, these growth factor levels tend to decrease to near-normal ranges in responders but were still high in most non-responders.
Negative_regulation (decrease) of growth factor
11) Confidence 0.01 Published 2002 Journal Jpn. J. Cancer Res. Section Abstract Doc Link 12359057 Disease Relevance 0.89 Pain Relevance 0.11
In vitro, rasagiline protects against an array of toxins, including MPTP, 6-hydroxydopamine (6-OHDA) and serum and growth factor deprivation (reviewed in38).
Negative_regulation (deprivation) of growth factor associated with parkinson's disease
12) Confidence 0.01 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2877525 Disease Relevance 1.12 Pain Relevance 0.03
The intrinsic pathway mediates apoptotic responses to stress signals such as drugs, DNA damage or growth factor deprivation and is initiated by mitochondrial damage.
Negative_regulation (deprivation) of growth factor associated with stress and apoptosis
13) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386551 Disease Relevance 0.94 Pain Relevance 0
Cellular stress can be caused by oxidative stress through free radicals, deprivation of growth factor, or exposure to radiation or chemicals.
Negative_regulation (deprivation) of growth factor associated with stress
14) Confidence 0.01 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.78 Pain Relevance 0
Andrographolide suppresess apoptosis of human umbilical vein endothelial cells (HUVECs) induced by growth factor deprivation via the activation of PI3/Akt pathway [108].
Negative_regulation (deprivation) of growth factor in endothelial cells associated with apoptosis
15) Confidence 0.00 Published 2010 Journal Chin Med Section Body Doc Link PMC2881933 Disease Relevance 0.24 Pain Relevance 0.04

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