INT105608

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Context Info
Confidence 0.68
First Reported 2002
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 17
Disease Relevance 8.53
Pain Relevance 4.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Mc3r) plasma membrane (Mc3r) signal transducer activity (Mc3r)
Anatomy Link Frequency
hypothalamus 2
macrophages 1
MC3 1
blood 1
monocytes 1
Mc3r (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 99 99.98 Very High Very High Very High
melanocortin 1 receptor 29 99.96 Very High Very High Very High
Arthritis 27 99.32 Very High Very High Very High
cytokine 117 98.92 Very High Very High Very High
Inflammation 439 98.00 Very High Very High Very High
Inflammatory response 22 97.60 Very High Very High Very High
ischemia 21 97.60 Very High Very High Very High
gABA 24 95.92 Very High Very High Very High
antagonist 55 94.80 High High
Inflammatory stimuli 38 84.48 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 12 99.96 Very High Very High Very High
Stress 30 99.36 Very High Very High Very High
Arthritis 38 99.32 Very High Very High Very High
Appetite Loss 75 98.80 Very High Very High Very High
Diabetes Mellitus 30 98.76 Very High Very High Very High
Reperfusion Injury 10 98.52 Very High Very High Very High
Adhesions 48 98.08 Very High Very High Very High
INFLAMMATION 519 98.00 Very High Very High Very High
Cv Unclassified Under Development 22 97.60 Very High Very High Very High
Vasculitis 15 96.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, activation of MC3R is essential to exert a tonic inhibitory action during the inflammatory response that occurs in this experimental model.
Positive_regulation (activation) of MC3R associated with inflammatory response
1) Confidence 0.68 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.74 Pain Relevance 0.34
Interestingly, activation of the MC3R by ?
Positive_regulation (activation) of MC3R
2) Confidence 0.67 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 0.53 Pain Relevance 0.40
Yet, when we divided our EX group into LR and HR, we observed a significant upregulation (34.9 fold) of MC3R with a statistical power of 0.902.
Positive_regulation (upregulation) of MC3R
3) Confidence 0.67 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 0.23 Pain Relevance 0.18
Regardless of sample size, however, we observed a statistically significant upregulation (16-fold) of the MC3R in our participants with a statistical power of 0.5811 with the current number of subjects.
Positive_regulation (upregulation) of MC3R
4) Confidence 0.67 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 0.23 Pain Relevance 0.19
Within the mesenteric artery, it has been shown that stimulation of MC3R by ?
Positive_regulation (stimulation) of MC3R in mesenteric artery
5) Confidence 0.67 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 0.95 Pain Relevance 0.42
A large proportion of NPY neurones in the rat hypothalamus express mc3r mRNA while a much lower number of NPY neurones express mc4r mRNA, suggesting that POMC neurones may directly modulate the activity of the hypothalamic NPY system too, mainly through activation of MC3R [61].
Positive_regulation (activation) of MC3R in hypothalamus
6) Confidence 0.51 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.48 Pain Relevance 0.33
I/R leads to a nonsignificant decrease in CD62L expression in WT F4/80 cells, whereas a significant decrease in CD62L expression was observed in MC3R-null animals (Table 3), suggesting that the mononuclear phagocyte compartment is highly activated in the MC3R-null animals after I/R.


Positive_regulation (activated) of MC3R-null in F4/80
7) Confidence 0.49 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.18 Pain Relevance 0
The mechanism underlying the increased adiposity in the MC3R knockout remains unclear, but might be related to changes in nutrient partitioning or physical activity.
Positive_regulation (increased) of MC3R associated with targeted disruption
8) Confidence 0.49 Published 2002 Journal Neuropeptides Section Abstract Doc Link 12359499 Disease Relevance 0.69 Pain Relevance 0.10
Redundancy of a functional melanocortin 1 receptor in the anti-inflammatory actions of melanocortin peptides: studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor.
Positive_regulation (role) of melanocortin 3 receptor associated with inflammation, melanocortin 1 receptor and cytokine
9) Confidence 0.49 Published 2003 Journal J. Immunol. Section Title Doc Link 12626592 Disease Relevance 0.28 Pain Relevance 0.54
Agonist stimulation of MC3R also decreases arthritis incidence and severity, evidenced by decreased nuclear factor kappa B (NF?
Positive_regulation (stimulation) of MC3R associated with agonist and arthritis
10) Confidence 0.48 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 1.04 Pain Relevance 0.46
Resistance training upregulated melanocortin 3 receptor mRNA by 16-fold (P = .035) and decreased monocyte count, without changing leukocyte number, body composition, or body weight.
Positive_regulation (upregulated) of melanocortin 3 receptor in body associated with body weight
11) Confidence 0.48 Published 2011 Journal Journal of Aging Research Section Abstract Doc Link PMC3022199 Disease Relevance 0.57 Pain Relevance 0.12
The melanocortin receptor subtypes, MC1R, MC3R, and MC5R are found on the plasma membranes of monocytes, macrophages, CD4+ T helper cells, granulocytes, and natural killer cells where, separately, they are activated in response to stress [12, 17–19].
Positive_regulation (activated) of MC3R in macrophages associated with stress and melanocortin 1 receptor
12) Confidence 0.45 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 0.42 Pain Relevance 0.49
These cytokines may be associated with increased exercise-induced concentrations of ACTH and our observed monocyte/macrophage (whole blood) sensitization and MC3R upregulation.
Positive_regulation (upregulation) of MC3R in blood associated with cytokine
13) Confidence 0.45 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 0.28 Pain Relevance 0.30
A large proportion of NPY neurones in the rat hypothalamus express mc3r mRNA while a much lower number of NPY neurones express mc4r mRNA, suggesting that POMC neurones may directly modulate the activity of the hypothalamic NPY system too, mainly through activation of MC3R [61].
Positive_regulation (neurones) of mc3r in hypothalamus
14) Confidence 0.42 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.40 Pain Relevance 0.29
Whilst not being shown to activate hypothalamic neurones in vivo [42], it binds to and activates both MC3R and MC4R in vitro and has an anorectic effect at high doses in vivo [123].
Positive_regulation (activates) of MC3R associated with appetite loss
15) Confidence 0.39 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.30 Pain Relevance 0
Activation of MC3R led to reduced myocardial cytokine production and myeloperoxidase activity, and these effects were prevented by the mixed MC3/4R antagonist SHU9119, but not by the selective MC4R antagonist HS204 (Getting et al. 2004).
Positive_regulation (Activation) of MC3R in MC3 associated with antagonist and cytokine
16) Confidence 0.24 Published 2010 Journal The Journal of Endocrinology Section Body Doc Link PMC2887273 Disease Relevance 0.78 Pain Relevance 0.18
The melanocortin receptor subtypes, MC1R, MC3R, and MC5R are found on the plasma membranes of monocytes, macrophages, CD4+ T helper cells, granulocytes, and natural killer cells where, separately, they are activated in response to stress [12, 17–19].
Positive_regulation (activated) of MC3R in monocytes associated with stress and melanocortin 1 receptor
17) Confidence 0.15 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 0.42 Pain Relevance 0.49

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