INT10565

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.53
First Reported 1972
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 94
Total Number 95
Disease Relevance 37.35
Pain Relevance 19.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
cartilages 3
luteal cell 2
uterine 2
amnion 1
decidua 1
MRXS5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 796 100.00 Very High Very High Very High
Inflammatory mediators 113 100.00 Very High Very High Very High
cINOD 260 99.78 Very High Very High Very High
antagonist 98 99.76 Very High Very High Very High
Inflammatory response 59 99.70 Very High Very High Very High
Spinal cord 65 99.68 Very High Very High Very High
cytokine 282 99.62 Very High Very High Very High
COX2 14 99.48 Very High Very High Very High
tolerance 8 99.46 Very High Very High Very High
COX-2 inhibitor 109 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1076 100.00 Very High Very High Very High
Squamous Cell Carcinoma 2 99.84 Very High Very High Very High
Peptic Ulcer 9 99.66 Very High Very High Very High
Rheumatoid Arthritis 22 99.60 Very High Very High Very High
Stress 153 99.26 Very High Very High Very High
Disease 293 99.24 Very High Very High Very High
Hypersensitivity 45 99.08 Very High Very High Very High
Fever 12 98.80 Very High Very High Very High
Hyperalgesia 40 98.64 Very High Very High Very High
Alzheimer's Dementia 13 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clinicians need to know the endogenous biosynthesis of PGs, their metabolism, and their detection to use PGs therapeutically with competence.
Gene_expression (biosynthesis) of PGs
1) Confidence 0.53 Published 1973 Journal J Reprod Med Section Abstract Doc Link 4571712 Disease Relevance 0 Pain Relevance 0.05
This study indicates that endogenous PGs may be involved in the pathogenesis of gastric ulcer and that normal generation of mucosal PGs is essential for the mucosal integrity.
Gene_expression (generation) of PGs associated with peptic ulcer
2) Confidence 0.53 Published 1984 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 6599541 Disease Relevance 0.65 Pain Relevance 0.25
In contrast, paracetamol or carprofen, a novel NOSAC, fails to affect mucosal generation of PGs and does not influence gastric mucosal integrity.
Gene_expression (generation) of PGs associated with paracetamol
3) Confidence 0.53 Published 1984 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 6599541 Disease Relevance 0.58 Pain Relevance 0.27
In contrast, carprofen, a novel NOSAC with good antiinflammatory properties and gastric tolerance, failed to affect mucosal generation of PGs and did not influence gastric mucosal integrity.
Gene_expression (generation) of PGs associated with inflammation and tolerance
4) Confidence 0.53 Published 1984 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 6588526 Disease Relevance 0.76 Pain Relevance 0.25
This biosynthesis was worked out in sheep seminal vesicles, but it is now recognized that virtually all tissue types in mammals synthesize PGs.
Gene_expression (synthesize) of PGs in seminal vesicles
5) Confidence 0.53 Published 1973 Journal J Reprod Med Section Abstract Doc Link 4571712 Disease Relevance 0 Pain Relevance 0.04
Apparently, endogenous biosynthesis of PGs is catalyzed by a microsomal enzyme system composed of many different enzyme types.
Gene_expression (biosynthesis) of PGs
6) Confidence 0.53 Published 1973 Journal J Reprod Med Section Abstract Doc Link 4571712 Disease Relevance 0 Pain Relevance 0.04
Studies have shown that anti-inflammatory drugs block the synthesis of PGs, and antagonists competitively inhibit the action of these compounds in the body.
Gene_expression (synthesis) of PGs in body associated with inflammation, antagonist and cinod
7) Confidence 0.53 Published 1989 Journal Zhonghua Ya Yi Xue Hui Za Zhi Section Abstract Doc Link 2701289 Disease Relevance 0.65 Pain Relevance 0.19
Although PGs were originally named and discovered in the prostate gland of man and sheep, current evidence suggests that PGs are synthesized by nearly all mammalian cells.
Gene_expression (synthesized) of PGs in prostate gland
8) Confidence 0.53 Published 1989 Journal Zhonghua Ya Yi Xue Hui Za Zhi Section Abstract Doc Link 2701289 Disease Relevance 0.36 Pain Relevance 0
The high concentrations of pro-inflammatory prostaglandins (PGs) produced in the joint during the initial stage of inflammation can be decreased by inhibiting their biosynthesis with nonsteroidal anti-inflammatory drugs (NSAIDs).
Gene_expression (produced) of PGs in joint associated with inflammation and cinod
9) Confidence 0.52 Published 1989 Journal Clin. Rheumatol. Section Abstract Doc Link 2525980 Disease Relevance 0.42 Pain Relevance 0.46
The chemical structure and synthesis of PGs is explained and illustrated in chemical structure diagram.
Gene_expression (synthesis) of PGs
10) Confidence 0.52 Published 1972 Journal Chem Drug Section Abstract Doc Link 12262561 Disease Relevance 0.61 Pain Relevance 0.46
In some studies, the maintenance of normal mucosal integrity has been linked to normal mucosal production of PGs.
Gene_expression (production) of PGs
11) Confidence 0.52 Published 1986 Journal Dig. Dis. Sci. Section Abstract Doc Link 3943457 Disease Relevance 1.21 Pain Relevance 0.36
The discovery in 1971 that acetylsalicylic acid and a series of other nonsteroidal anti-inflammatory drugs inhibit the biosynthesis of PGs provided an explanation for the analgetic, antipyretic, and anti-inflammatory activity of these drugs and formed a rational base for their use in a variety of pathological situations believed to involve PGs.
Gene_expression (biosynthesis) of PGs associated with aspirin, inflammation and cinod
12) Confidence 0.51 Published 1983 Journal Acta Clin Belg Section Abstract Doc Link 6868938 Disease Relevance 0.69 Pain Relevance 0.20
High levels of prostaglandins (PGs) are currently found in tumoral cells, due to expression of the inducible PGs synthesis enzyme, the cyclooxygenase 2 (COX 2).
Gene_expression (expression) of PGs associated with cox2
13) Confidence 0.50 Published 2001 Journal Prostaglandins Other Lipid Mediat. Section Abstract Doc Link 11352223 Disease Relevance 0.22 Pain Relevance 0.30
High levels of prostaglandins (PGs) are currently found in tumoral cells, due to expression of the inducible PGs synthesis enzyme, the cyclooxygenase 2 (COX 2).
Gene_expression (synthesis) of PGs associated with cox2
14) Confidence 0.50 Published 2001 Journal Prostaglandins Other Lipid Mediat. Section Abstract Doc Link 11352223 Disease Relevance 0.22 Pain Relevance 0.30
In the course of pregnancy amnion cells produce a number of factors which include cytokines and prostaglandins (PGs) produced in response to autocrine, paracrine and endocrine signals.
Gene_expression (produced) of PGs in amnion associated with cytokine
15) Confidence 0.37 Published 2003 Journal Curr. Drug Targets Immune Endocr. Metabol. Disord. Section Abstract Doc Link 12570726 Disease Relevance 0 Pain Relevance 0.05
We examined the effects of these enzymes and the serine proteases on endogenous proteoglycans (PGs) and newly synthesized PGs of seven RA cartilages.
Gene_expression (synthesized) of PGs in cartilages associated with rheumatoid arthritis
16) Confidence 0.36 Published 1992 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 1505108 Disease Relevance 0.36 Pain Relevance 0.05
We examined the effects of these enzymes and the serine proteases on endogenous proteoglycans (PGs) and newly synthesized PGs of seven RA cartilages.
Gene_expression (synthesized) of PGs in cartilages associated with rheumatoid arthritis
17) Confidence 0.36 Published 1992 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 1505108 Disease Relevance 0.36 Pain Relevance 0.10
Gallbladder segments treated with LC did not show a decreased production of any of the three PGs whereas 5-HETE released to the medium was significantly lower.
Gene_expression (production) of PGs
18) Confidence 0.32 Published 2000 Journal Medicina (B Aires) Section Abstract Doc Link 11188896 Disease Relevance 0.13 Pain Relevance 0.13
Since PGs are produced in various ocular tissues and some of these PGs are highly potent ocular hypotensive agents, their potential role in mediating the reduction of IOP produced by medical or surgical modalities of glaucoma therapy must always be considered.
Gene_expression (produced) of PGs associated with hypotension and glaucoma
19) Confidence 0.30 Published 1989 Journal Prog. Clin. Biol. Res. Section Abstract Doc Link 2508130 Disease Relevance 0.96 Pain Relevance 0.21
These data clearly indicate that the increased renal synthesis of vasodilating PGs has a relevant role in maintaining renal hemodynamics, sodium and water excretion in a clinical setting characterized by a reduction of effective plasma volume and a striking activation of the major vasoconstricting systems, namely the renin-angiotensin-aldosterone, the sympathetic nervous system, and vasopressin.
Gene_expression (synthesis) of PGs in sympathetic nervous system
20) Confidence 0.30 Published 1997 Journal Semin. Nephrol. Section Abstract Doc Link 9353864 Disease Relevance 0.32 Pain Relevance 0.18

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox