INT105670

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 2002
Last Reported 2011
Negated 6
Speculated 0
Reported most in Body
Documents 131
Total Number 138
Disease Relevance 49.24
Pain Relevance 12.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 7
epithelial cells 6
endothelial cells 4
retina 3
brain 3
AAVS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
dopaminergic neurodegeneration 15 100.00 Very High Very High Very High
Neuropeptide 216 99.84 Very High Very High Very High
Spinal cord 283 99.76 Very High Very High Very High
Neuropathic pain 267 99.38 Very High Very High Very High
Hippocampus 37 99.16 Very High Very High Very High
gABA 12 98.88 Very High Very High Very High
Arthritis 197 98.48 Very High Very High Very High
Substantia nigra 157 98.40 Very High Very High Very High
Lasting pain 16 98.00 Very High Very High Very High
Sciatica 3 97.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
Infection 393 100.00 Very High Very High Very High
Targeted Disruption 290 100.00 Very High Very High Very High
Vasculitis 62 100.00 Very High Very High Very High
Breast Cancer 78 99.92 Very High Very High Very High
Nervous System Injury 26 99.92 Very High Very High Very High
Ganglion Cysts 39 99.84 Very High Very High Very High
Aids-related Complex 450 99.60 Very High Very High Very High
Body Weight 131 99.54 Very High Very High Very High
Coagulation Disorder 53 99.44 Very High Very High Very High
Cytomegalovirus Infection 481 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recombinant AAV serotype 5 (rAAV5) carrying the NDI1 gene (designated rAAV5-NDI1) was produced by and purchased from Applied Viromics (Fremont, CA).
Gene_expression (produced) of AAV
1) Confidence 0.75 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3005838 Disease Relevance 0.18 Pain Relevance 0.25
This appears to be a greater proportion of cones than previously recorded in a study using an AAV2 vector expressing GFP under the CMV promoter [22].
Gene_expression (expressing) of AAV in cones associated with cytomegalovirus infection
2) Confidence 0.75 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2743804 Disease Relevance 0.10 Pain Relevance 0
In mice, a comparison of reporter gene expression in the outer retina following subretinal injection has shown that scAAV2 transgene expression is faster and stronger compared with that achieved by the equivalent ssAAV2 vector [18].
Gene_expression (expression) of AAV in retina
3) Confidence 0.75 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2743804 Disease Relevance 0.06 Pain Relevance 0
Construction of pAAV2apoE
Gene_expression (Construction) of AAV
4) Confidence 0.65 Published 2009 Journal Virol J Section Body Doc Link PMC2687429 Disease Relevance 0 Pain Relevance 0
To test this hypothesis, we employed adeno-associated virus serotype 2 (AAV2) to selectively over-express human ?
Gene_expression (employed) of AAV
5) Confidence 0.65 Published 2010 Journal Mol Neurodegener Section Abstract Doc Link PMC2975641 Disease Relevance 0.42 Pain Relevance 0.24
A study comparing multiple AAV serotypes delivered by subretinal injection in mice showed that scAAV2/8 expressing green fluorescent protein (GFP) had faster and stronger expression than the equivalent ssAAV2/8 construct.
Gene_expression (/) of AAV
6) Confidence 0.65 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2743804 Disease Relevance 0 Pain Relevance 0
When tumors had reached 7–8 mm in diameter, intratumoral injection of AAV-2/TRE/HSVtk/Tet-On (100 ?
Gene_expression (injection) of AAV associated with cancer
7) Confidence 0.65 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1463003 Disease Relevance 0.72 Pain Relevance 0.08
To test this hypothesis, we employed adeno-associated virus serotype 2 (AAV2) to selectively over-express human ?
Gene_expression (express) of AAV
8) Confidence 0.65 Published 2010 Journal Mol Neurodegener Section Abstract Doc Link PMC2975641 Disease Relevance 0.42 Pain Relevance 0.24
Micro-dystrophin expression by rAAV8 and rAAV6 showed protection against eccentric contraction injury.
Gene_expression (expression) of AAV associated with injury
9) Confidence 0.65 Published 2007 Journal J Transl Med Section Body Doc Link PMC2082019 Disease Relevance 0.22 Pain Relevance 0
An adeno-associated viral expression vector for Cre recombinase (AAV-Cre, titer of 5–8×1010) was streotaxically microinjected to the hippocampal CA3 region of GluR?
Gene_expression (expression) of AAV associated with glutamate receptor
10) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0.33 Pain Relevance 0.43
Therefore, the improved transduction of AAV2/8 with an Ad5 MOI of 10 may be due to enhanced nuclear translocation or viral uncoating.
Gene_expression (transduction) of AAV
11) Confidence 0.65 Published 2009 Journal Virol J Section Body Doc Link PMC2687429 Disease Relevance 0.14 Pain Relevance 0.08
The most efficient vector in this experiment was AAV2/5 (Figs. 1G–I).
Gene_expression (/) of AAV
12) Confidence 0.65 Published 2009 Journal Virol J Section Body Doc Link PMC2687429 Disease Relevance 0.08 Pain Relevance 0
Although Ad5 can enhance AAV2 transduction by stimulating AAV2 DNA second-strand synthesis [24,27], Ad5 capsids also facilitate translocation of AAV2 into the nucleus [28].
Gene_expression (transduction) of AAV in nucleus
13) Confidence 0.65 Published 2009 Journal Virol J Section Body Doc Link PMC2687429 Disease Relevance 0.16 Pain Relevance 0.09
Plasmids pAAV-RC, p5E18-VD2/8 and pXR5 contain AAV genes necessary for packaging AAV2 genomes into AAV2, AAV8 and AAV5 capsids, respectively, and pHelper contains adenovirus 5 (Ad5) genes required for helper functions.
Gene_expression (contain) of AAV
14) Confidence 0.65 Published 2009 Journal Virol J Section Body Doc Link PMC2687429 Disease Relevance 0.08 Pain Relevance 0
Construction of pAAVTGFP
Gene_expression (Construction) of AAV
15) Confidence 0.65 Published 2009 Journal Virol J Section Body Doc Link PMC2687429 Disease Relevance 0.09 Pain Relevance 0
Recombinant AAV serotype 5 (rAAV5) carrying the NDI1 gene (designated rAAV5-NDI1) was produced by and purchased from Applied Viromics (Fremont, CA).
Gene_expression (produced) of AAV
16) Confidence 0.58 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3005838 Disease Relevance 0.13 Pain Relevance 0.25
When delivered by subretinal injection in the dog, scAAV2/5 induces faster and stronger transgene expression than ssAAV2/5.
Gene_expression (expression) of AAV
17) Confidence 0.58 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2743804 Disease Relevance 0 Pain Relevance 0
We explored the treatment of human breast cancer by AAV-2 expressing HSVtk gene under the regulation of Tet-On, the rAAV (rAAV-2/TRE/HSVtk/Tet-On) was constructed and transduced into MCF-7 cell line or BALB/c nude mice.
Gene_expression (expressing) of AAV in MCF-7 associated with breast cancer
18) Confidence 0.58 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1463003 Disease Relevance 0.68 Pain Relevance 0
Similarly, transfection with an AAV encoding the gene for glutamic acid decarboxylase, synthesizing the inhibitory transmitter GABA has been shown to reduce the excitatory output from the subthalamic nucleus, improving motor cortex activity and consequently in both rodent and macaques models of PD restoring motor function (Luo et al 2002; Lee et al 2005; Emborg et al 2007).


Gene_expression (transfection) of AAV in subthalamic nucleus associated with gaba and disease
19) Confidence 0.45 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626922 Disease Relevance 0.09 Pain Relevance 0.37
The first trials carried out with the AAV2 containing neurturin have not demonstrated any adverse side effects, however this only encompasses a small group of patients followed over a short period of time.
Gene_expression (containing) of AAV2
20) Confidence 0.45 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626922 Disease Relevance 0.44 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox