INT105677

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Context Info
Confidence 0.37
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.22
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Vegfa) extracellular space (Vegfa) growth (Vegfa)
extracellular region (Vegfa) cytoplasm (Vegfa)
Anatomy Link Frequency
fibroblast 1
head 1
Vegfa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Osteoarthritis 12 83.28 Quite High
cOX1 1 79.68 Quite High
metalloproteinase 4 71.28 Quite High
tolerance 2 67.56 Quite High
Pain 4 65.76 Quite High
Restless leg syndrome 2 65.52 Quite High
Inflammation 10 56.00 Quite High
cINOD 6 53.44 Quite High
ischemia 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 24 99.78 Very High Very High Very High
Ulcers 26 99.72 Very High Very High Very High
Aseptic Necrosis Of Bone 55 99.42 Very High Very High Very High
Malignant Neoplastic Disease 1 97.52 Very High Very High Very High
Cancer 45 96.00 Very High Very High Very High
Canker Sores 3 94.36 High High
Cv Unclassified Under Development 14 92.60 High High
Increased Venous Pressure Under Development 7 90.08 High High
Recurrence 2 89.84 High High
Apoptosis 27 84.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
METHODS: In situ hybridization was performed on an idiopathic aphthous ulcer using probes specific for the angiogenesis factor vascular endothelial growth factor, and its receptors, in order to determine whether these ulcers are highly angiogenic.
vascular endothelial growth factor Binding (receptors) of
1) Confidence 0.37 Published 2003 Journal J Cutan Med Surg Section Body Doc Link 12574903 Disease Relevance 0.09 Pain Relevance 0
There were improvements 14 days after ligation with VEGFA and VEGFB treatments compared with the vehicle control plasmid treatment, but a deficit remained of some 32%. 4.
VEGFA Binding (ligation) of
2) Confidence 0.29 Published 2002 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 12366398 Disease Relevance 0.70 Pain Relevance 0.17
Reactive hyperaemic responses were significantly attenuated 7 days after ligation in the vehicle and VEGFA treatment groups.
VEGFA Binding (ligation) of
3) Confidence 0.29 Published 2002 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 12366398 Disease Relevance 0.68 Pain Relevance 0.14
Gene therapy with epidermal growth factor and vascular endothelial growth factor applied to the base of acetic acid ulcers in rats is effective in enhancing ulcer healing.
vascular endothelial growth factor Binding (therapy) of associated with ulcers
4) Confidence 0.21 Published 2005 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16079471 Disease Relevance 1.63 Pain Relevance 0.05
Tarnawski et al. [28] previously reported that rebamipide significantly upregulated the proangiogenic genes encoding vascular endothelial growth factor (VEGF), heparin binding epidermal growth-like factor (HB-EGF), fibroblast growth factor receptor-2 (FGFR2), and cyclooxygenase-2 (Cox2), as well as growth promoting genes, including insulin growth factor-1 (IGF-1).
vascular endothelial growth factor Binding (binding) of in fibroblast
5) Confidence 0.18 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2243244 Disease Relevance 0.32 Pain Relevance 0.07
The synovial fibroblasts in the distended joint capsule of rats with vessel-deprived osteonecrosis of the femoral head are jam-packed with vascular endothelial growth factor.
endothelial growth Binding (packed) of in head associated with aseptic necrosis of bone
6) Confidence 0.14 Published 2005 Journal Theor Biol Med Model Section Body Doc Link PMC1208957 Disease Relevance 0.38 Pain Relevance 0.04
In gliomas, the best characterized pro-angiogenic factor is vascular endothelial growth factor (VEGF), whose overexpression is correlated with increasingly malignant phenotypes [18].
vascular endothelial growth factor Binding (characterized) of associated with malignant neoplastic disease and glioma
7) Confidence 0.11 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 1.42 Pain Relevance 0.04

General Comments

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