INT10568

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Context Info
Confidence 0.20
First Reported 1992
Last Reported 2007
Negated 2
Speculated 1
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 1.86
Pain Relevance 6.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (H2-Ab1) plasma membrane (H2-Ab1) intracellular (H2-Ab1)
transcription factor binding (H2-Ab1)
Anatomy Link Frequency
PVN 2
nerve 1
bladder 1
DRG 1
H2-Ab1 (Mus musculus)
Pain Link Frequency Relevance Heat
Abeta 21 100.00 Very High Very High Very High
wide dynamic range 6 100.00 Very High Very High Very High
opioid receptor 12 99.98 Very High Very High Very High
Adelta 9 99.76 Very High Very High Very High
gABA 7 99.74 Very High Very High Very High
antagonist 4 99.68 Very High Very High Very High
c fibre 13 99.64 Very High Very High Very High
Morphine 3 99.64 Very High Very High Very High
dorsal root ganglion 6 99.60 Very High Very High Very High
substance P 14 99.46 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 6 99.60 Very High Very High Very High
Pressure And Volume Under Development 1 99.18 Very High Very High Very High
Nociception 7 98.62 Very High Very High Very High
Facial Pain 2 91.68 High High
Cystitis 2 91.36 High High
INFLAMMATION 6 88.80 High High
Handedness 1 84.52 Quite High
Pain 2 75.00 Quite High
Targeted Disruption 1 64.32 Quite High
Nervous System Injury 2 49.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study examined the contribution of vanilloid-1 (TRPV1), peripheral NK1 receptors to CPM-evoked nociceptive behaviors and bladder edema, and its possible modulation by alpha, beta-amyrin.
Spec (possible) Regulation (modulation) of beta-amyrin in bladder associated with nociception and pressure and volume under development
1) Confidence 0.20 Published 2007 Journal Inflamm. Res. Section Abstract Doc Link 18210232 Disease Relevance 0.51 Pain Relevance 0.08
In control cat, the topical use of SP in DRG did not induce any response of Abeta neurons.
Regulation (response) of Abeta in DRG associated with dorsal root ganglion, abeta and substance p
2) Confidence 0.19 Published 2001 Journal Brain Res. Section Abstract Doc Link 11743978 Disease Relevance 0.79 Pain Relevance 1.49
No Abeta afferent-related response was found.
Regulation (response) of Abeta associated with abeta
3) Confidence 0.11 Published 1998 Journal Neurosci. Lett. Section Abstract Doc Link 9507948 Disease Relevance 0.16 Pain Relevance 0.30
We discuss our observation that the PVN electrical stimulation selectively inhibits Adelta and C-fiber activity without affecting Abeta fibers.
Neg (without) Regulation (affecting) of Abeta in PVN associated with c fibre, adelta and abeta
4) Confidence 0.09 Published 2007 Journal Brain Res. Section Abstract Doc Link 17229405 Disease Relevance 0.09 Pain Relevance 0.93
SR141716A, a CB1 receptor antagonist, prevented the effects of WIN on WDR PDC and LTM Abeta evoked activity.
Regulation (effects) of Abeta associated with antagonist, wide dynamic range and abeta
5) Confidence 0.05 Published 2004 Journal Pain Section Abstract Doc Link 14736589 Disease Relevance 0.24 Pain Relevance 1.29
Our data demonstrate that GABA(A)-receptor control of Abeta- and Adelta-fibre evoked responses are not altered in nerve injured or sham operated rats, compared to control.
Regulation (control) of Abeta in nerve associated with gaba, adelta and abeta
6) Confidence 0.04 Published 2003 Journal Brain Res. Section Abstract Doc Link 12543472 Disease Relevance 0 Pain Relevance 1.09
Phosphorylation of the delta-opioid receptor regulates its beta-arrestins selectivity and subsequent receptor internalization and adenylyl cyclase desensitization.
Regulation (regulates) of beta-arrestins associated with opioid receptor
7) Confidence 0.00 Published 2007 Journal J. Biol. Chem. Section Title Doc Link 17565992 Disease Relevance 0 Pain Relevance 0.48
In this report, we present a rationale to explain the seemingly paradoxical relationship between beta-arrestins and microOR regulation wherein morphine-like agonists fail to promote efficient internalization and resensitization of the receptor.
Regulation (regulation) of beta-arrestins associated with agonist and morphine
8) Confidence 0.00 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15213301 Disease Relevance 0.06 Pain Relevance 0.98
Placement of DEX adjacent to the fetal PVN prevented reemergence of expression of mRNA for P450(17)alpha and P450scc at 126-128 dGA, but had no effect on mRNA for P450C21 or P45011 beta.
Neg (no) Regulation (effect) of P45011 beta in PVN
9) Confidence 0.00 Published 1992 Journal Endocrinology Section Abstract Doc Link 1505467 Disease Relevance 0 Pain Relevance 0.16

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