| Inhibiting p38 activation in the DRG reduces the increase in TRPV1 in the DRG and inflamed skin and diminishes inflammation-induced heat hypersensitivity without affecting inflammatory swelling or basal pain sensitivity. p38 activation in the DRG is secondary to peripheral production of NGF during inflammation and is required for NGF-induced increases in TRPV1.
| NGF Positive_regulation (increases) of TRPV1 in skin associated with pain, dorsal root ganglion, pressure and volume under development, inflammation and hypersensitivity
|| Doc Link
|| Disease Relevance
|| Pain Relevance
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