INT105690

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Context Info
Confidence 0.05
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.43
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (TRPV1) aging (Ngf) lipid metabolic process (TRPV1)
cytosol (TRPV1) extracellular space (Ngf) signal transduction (Ngf)
Anatomy Link Frequency
skin 1
Ngf (Rattus norvegicus)
TRPV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 9 99.58 Very High Very High Very High
dorsal root ganglion 6 98.28 Very High Very High Very High
Pain 1 97.50 Very High Very High Very High
nociceptor 4 91.92 High High
c fibre 2 86.24 High High
Hyperalgesia 1 75.00 Quite High
neuralgia 2 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 7 99.58 Very High Very High Very High
Ganglion Cysts 6 98.28 Very High Very High Very High
Pain 1 97.50 Very High Very High Very High
Pressure And Volume Under Development 1 97.22 Very High Very High Very High
Hypersensitivity 2 96.42 Very High Very High Very High
Hyperalgesia 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibiting p38 activation in the DRG reduces the increase in TRPV1 in the DRG and inflamed skin and diminishes inflammation-induced heat hypersensitivity without affecting inflammatory swelling or basal pain sensitivity. p38 activation in the DRG is secondary to peripheral production of NGF during inflammation and is required for NGF-induced increases in TRPV1.
NGF Positive_regulation (increases) of TRPV1 in skin associated with pain, dorsal root ganglion, pressure and volume under development, inflammation and hypersensitivity
1) Confidence 0.05 Published 2002 Journal Neuron Section Abstract Doc Link 12367506 Disease Relevance 1.43 Pain Relevance 1.08

General Comments

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