INT105694

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Context Info
Confidence 0.46
First Reported 2002
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 8.47
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SFTPD) extracellular region (SFTPD) lysosome (SFTPD)
SFTPD (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 215 99.80 Very High Very High Very High
rheumatoid arthritis 440 99.42 Very High Very High Very High
cINOD 3 75.00 Quite High
cytokine 11 65.96 Quite High
methotrexate 72 58.80 Quite High
Inflammatory mediators 18 53.16 Quite High
diclofenac 1 43.20 Quite Low
Inflammatory response 21 35.20 Quite Low
chemokine 2 32.36 Quite Low
corticosteroid 4 28.32 Quite Low
Disease Link Frequency Relevance Heat
Obesity 133 100.00 Very High Very High Very High
Disease 218 99.80 Very High Very High Very High
INFLAMMATION 215 99.80 Very High Very High Very High
Rheumatoid Arthritis 440 99.42 Very High Very High Very High
Congenital Anomalies 18 97.20 Very High Very High Very High
Synovitis 32 95.52 Very High Very High Very High
Apoptosis 17 93.88 High High
Nicotine Addiction 106 92.88 High High
Epilepsy 1 92.40 High High
Death 7 84.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present investigation extends our previous observation by readdressing the possible association between SP-D and the Met11Thr polymorphism in early, untreated RA, and by studying the correlation between SP-D and disease activity measures and radiographic progression during a four-year interventional study on DMARD naïve patients with RA of recent onset.
SP-D Binding (association) of associated with rheumatoid arthritis and disease
1) Confidence 0.46 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.50 Pain Relevance 0.16
Thus, in healthy subjects the Thr11-variant is associated with low SP-D in the circulation [22].
SP-D Binding (associated) of
2) Confidence 0.46 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 1.01 Pain Relevance 0.31
Such a scavenger mechanism for SP-D in RA is supported by the inverse association between SP-D and disease activity measures and by the gradual SP-D increase during treatment.
SP-D Binding (association) of associated with rheumatoid arthritis and disease
3) Confidence 0.46 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.93 Pain Relevance 0.33
We found no association between SP-D and radiographic data including estimated annual progression rate (data not shown).
SP-D Neg (no) Binding (association) of
4) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.71 Pain Relevance 0.13
The inverse association of SP-D and inflammatory signs and the lack of association between SP-D and erosive progression after four years indicate, that subnormal SP-D is primarily linked to systemic inflammation.
SP-D Binding (association) of associated with inflammation
5) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.88 Pain Relevance 0.31
The inverse association of SP-D and inflammatory signs and the lack of association between SP-D and erosive progression after four years indicate, that subnormal SP-D is primarily linked to systemic inflammation.
SP-D Binding (association) of associated with inflammation
6) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.94 Pain Relevance 0.34
DP-VPA (SPD 421) is a new compound, where valproic acid is chemically bound to lecithin.
SPD Binding (bound) of
7) Confidence 0.35 Published 2002 Journal J Pharm Biomed Anal Section Abstract Doc Link 12367664 Disease Relevance 0.17 Pain Relevance 0.07
While SP-D did not correlate with x-ray progression, we found an inverse association between SP-D and disease activity markers suggesting that low systemic SP-D is involved in the initiation or maintenance of synovitis.
SP-D Binding (association) of associated with synovitis and disease
8) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 1.26 Pain Relevance 0.36
SP-D was not associated to x-ray findings.


SP-D Binding (associated) of
9) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2888186 Disease Relevance 0.61 Pain Relevance 0.24
They observed no statistically significant association with serum SP-D and mortality [14].
serum SP-D Neg (no) Binding (association) of
10) Confidence 0.20 Published 2010 Journal Respir Res Section Body Doc Link PMC2907324 Disease Relevance 0.33 Pain Relevance 0
Interestingly, genetic variations in serum SP-D and BMI are correlated [118], and a negative association between serum SP-D and obesity measures was observed in humans [117].
serum SP-D Neg (negative) Binding (association) of associated with obesity
11) Confidence 0.10 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2857618 Disease Relevance 1.12 Pain Relevance 0.20

General Comments

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