INT10570

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Context Info
Confidence 0.47
First Reported 1992
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 2.67
Pain Relevance 1.40

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mitochondrion (Cyp11a1)
Anatomy Link Frequency
plasma 1
extracellular matrix 1
Cyp11a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
carbamazepine 1 99.76 Very High Very High Very High
anesthesia 6 98.80 Very High Very High Very High
halothane 6 98.58 Very High Very High Very High
COX-2 inhibitor 3 95.64 Very High Very High Very High
Morphine 1 95.20 Very High Very High Very High
Lamotrigine 1 94.68 High High
Gabapentin 1 94.04 High High
dexamethasone 6 93.84 High High
antiepileptic Drug 1 88.96 High High
adenocard 2 77.80 Quite High
Disease Link Frequency Relevance Heat
Generalized Epilepsy 1 99.32 Very High Very High Very High
Cancer 10 98.98 Very High Very High Very High
Epilepsy 11 98.14 Very High Very High Very High
Apoptosis 2 95.04 Very High Very High Very High
Mycobacterial Infection 6 95.00 High High
Cryptococcal Meningitis 20 93.16 High High
Syndrome 3 87.64 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 20 86.00 High High
Metastasis 1 85.52 High High
Breast Cancer 6 82.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data demonstrated that (1) S-petasin inhibits ACTH- or forskolin-stimulated cellular cAMP production, (2) S-petasin increased the Michaelis constants of P450scc and 11beta-hydroxylase and (3) S-petasin decreased the expression levels and mRNA of steroidogenic acute regulatory protein.
Positive_regulation (increased) of P450scc
1) Confidence 0.47 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15063152 Disease Relevance 0 Pain Relevance 0.07
Primary culture of rat hepatocytes in 96-well plates: effects of extracellular matrix configuration on cytochrome P450 enzyme activity and inducibility, and its application in in vitro cytotoxicity screening.
Positive_regulation (inducibility) of cytochrome P450 enzyme in extracellular matrix
2) Confidence 0.29 Published 2007 Journal Toxicol In Vitro Section Title Doc Link 17141466 Disease Relevance 0.07 Pain Relevance 0.05
These results indicated that strychnine and brucine cause phenobarbital-like induction of the P450 enzyme, but show a different profile from phenobarbital in the induction of UDP-glucuronosyltransferase.
Positive_regulation (induction) of P450 enzyme
3) Confidence 0.10 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7906730 Disease Relevance 0 Pain Relevance 0.10
Implanted fetuses were collected by cesarian section under halothane anesthesia at 126-128 dGA. mRNA for both cytochrome P450(17)alpha and P450scc declined 3-fold from 105 to 120 dGA (P less than or equal to 0.05), and then increased by 126-128 dGA compared to that on 120 dGA (P less than or equal to 0.05) and continued to increase through term.
Positive_regulation (increase) of P450scc associated with anesthesia and halothane
4) Confidence 0.05 Published 1992 Journal Endocrinology Section Abstract Doc Link 1505467 Disease Relevance 0 Pain Relevance 0.35
We conclude that mRNA for P450(17)alpha and P450scc undergoes a decline in expression concurrent with the previously described period of adrenal hyporesponsiveness from 105-126 dGA, followed by an increase in mRNA that accompanies the preterm rise in fetal plasma cortisol.
Positive_regulation (mRNA) of P450scc in plasma
5) Confidence 0.05 Published 1992 Journal Endocrinology Section Abstract Doc Link 1505467 Disease Relevance 0 Pain Relevance 0.16
Implanted fetuses were collected by cesarian section under halothane anesthesia at 126-128 dGA. mRNA for both cytochrome P450(17)alpha and P450scc declined 3-fold from 105 to 120 dGA (P less than or equal to 0.05), and then increased by 126-128 dGA compared to that on 120 dGA (P less than or equal to 0.05) and continued to increase through term.
Positive_regulation (increased) of P450scc associated with anesthesia and halothane
6) Confidence 0.05 Published 1992 Journal Endocrinology Section Abstract Doc Link 1505467 Disease Relevance 0 Pain Relevance 0.35
Moreover, these studies also suggest that mammary tumors are associated with high prostaglandin levels and induction of aromatase, a cytochrome P450 enzyme that catalyses estrogen production.
Positive_regulation (induction) of cytochrome P450 enzyme associated with cancer
7) Confidence 0.04 Published 2004 Journal Semin. Oncol. Section Abstract Doc Link 15179621 Disease Relevance 1.08 Pain Relevance 0.09
Rifampicin is a potent inducer of the cytochrome P450 enzyme system, of which fluconazole is a substrate.
Positive_regulation (inducer) of cytochrome P450 enzyme
8) Confidence 0.01 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1540428 Disease Relevance 0.73 Pain Relevance 0
Women without epilepsy (23 controls) and women with localization-related epilepsy (LRE, n = 59) or idiopathic (primary) generalized epilepsy (IGE, n = 35) receiving either a cytochrome P450 enzyme (cP450) inducing AED (carbamazepine, phenytoin, and phenobarbital), a cP450 inhibiting AED (valproate), or an AED that does not alter cP450 enzymes (lamotrigine and gabapentin) in monotherapy for 6 months or more were followed for three menstrual cycles.
Positive_regulation (inducing) of cytochrome P450 enzyme associated with epilepsy, lamotrigine, generalized epilepsy, gabapentin and carbamazepine
9) Confidence 0.01 Published 2002 Journal Ann. Neurol. Section Abstract Doc Link 12447923 Disease Relevance 0.79 Pain Relevance 0.24

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