INT105704

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Context Info
Confidence 0.46
First Reported 2002
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.23
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprl1) plasma membrane (Oprl1) signal transducer activity (Oprl1)
Anatomy Link Frequency
brain 2
skin 2
Oprl1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 13 100.00 Very High Very High Very High
opiate 3 100.00 Very High Very High Very High
orphanin 17 99.48 Very High Very High Very High
Endogenous opioid 2 93.04 High High
Hyperalgesia 1 88.00 High High
analgesia 2 85.68 High High
Opioid 1 80.44 Quite High
Pain 1 77.40 Quite High
Morphine 2 75.00 Quite High
addiction 1 74.64 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 3 99.72 Very High Very High Very High
Stereotypic Movement Disorder 5 98.60 Very High Very High Very High
Hyperalgesia 1 88.00 High High
Impulse Control Disorders 4 83.44 Quite High
Stress 2 82.96 Quite High
Pain 1 77.40 Quite High
Morphine Dependence 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nociceptin/orphanin FQ knockout mice display up-regulation of the opioid receptor-like 1 receptor and alterations in opioid receptor expression in the brain.
Positive_regulation (up-regulation) of Regulation (alterations) of opioid receptor-like 1 receptor in brain associated with targeted disruption, orphanin and opioid receptor
1) Confidence 0.46 Published 2003 Journal Neuroscience Section Title Doc Link 12605902 Disease Relevance 0.65 Pain Relevance 1.59
The aim of this study was to use fentanyl-induced prolactin response as an opiate receptor sensitivity test in patients with stereotypic movement disorder (SMD) manifesting SIB (skin picking).
Positive_regulation (induced) of Regulation (response) of opiate receptor in skin associated with stereotypic movement disorder and opiate
2) Confidence 0.01 Published 2002 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 12369265 Disease Relevance 0.58 Pain Relevance 0.36

General Comments

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