INT105723

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Context Info
Confidence 0.41
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.96
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
RVLM 1
connective 1
Mat1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 1 100.00 Very High Very High Very High
metalloproteinase 2 99.84 Very High Very High Very High
Rostral ventrolateral medulla 5 98.12 Very High Very High Very High
anesthesia 1 84.32 Quite High
Pain 2 83.60 Quite High
Inflammatory response 1 81.52 Quite High
Inflammation 1 35.60 Quite Low
Disease Link Frequency Relevance Heat
Depression 1 100.00 Very High Very High Very High
Death 2 97.84 Very High Very High Very High
Pressure Volume 2 Under Development 1 97.40 Very High Very High Very High
Endotoxemia 4 96.84 Very High Very High Very High
Myalgia 27 88.96 High High
Pain 1 83.60 Quite High
Systemic Inflammatory Response Syndrome 1 81.88 Quite High
INFLAMMATION 1 35.60 Quite Low
Body Weight 5 5.00 Very Low Very Low Very Low
Hypertrophy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is an evidence of a direct in vitro inhibitory effect of HICA on various matrix metalloproteinase enzymes, which are responsible for degradation of various connective and protein tissues [14].
Negative_regulation (effect) of mat in connective associated with metalloproteinase
1) Confidence 0.41 Published 2010 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2818616 Disease Relevance 0.34 Pain Relevance 0.21
Enzyme assay revealed significant depression of the activity of nicotinamide adenine dinucleotide cytochrome c reductase (Complexes I + III) and cytochrome c oxidase (Complex IV) in the RVLM during all three phases of endotoxemia.
Negative_regulation (depression) of Complexes I + III in RVLM associated with endotoxemia, rostral ventrolateral medulla and depression
2) Confidence 0.08 Published 2002 Journal J. Biomed. Sci. Section Abstract Doc Link 12372992 Disease Relevance 0.63 Pain Relevance 0.37

General Comments

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