INT105723

Context Info Confidence 0.41 First Reported 2002 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.96 Pain Relevance 0.58

Anatomy Link Frequency RVLM 1 connective 1 Mat1a (Rattus norvegicus)

Pain Link Frequency Relevance Heat depression 1 100.00 metalloproteinase 2 99.84 Rostral ventrolateral medulla 5 98.12 anesthesia 1 84.32 Pain 2 83.60 Inflammatory response 1 81.52 Inflammation 1 35.60

Disease Link Frequency Relevance Heat Depression 1 100.00 Death 2 97.84 Pressure Volume 2 Under Development 1 97.40 Endotoxemia 4 96.84 Myalgia 27 88.96 Pain 1 83.60 Systemic Inflammatory Response Syndrome 1 81.88 INFLAMMATION 1 35.60 Body Weight 5 5.00 Hypertrophy 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

There is an evidence of a direct in vitro inhibitory effect of HICA on various matrix metalloproteinase enzymes, which are responsible for degradation of various connective and protein tissues [14].

Negative_regulation (effect) of mat in connective associated with metalloproteinase

1) Confidence 0.41 Published 2010 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2818616 Disease Relevance 0.34 Pain Relevance 0.21

Enzyme assay revealed significant depression of the activity of nicotinamide adenine dinucleotide cytochrome c reductase (Complexes I + III) and cytochrome c oxidase (Complex IV) in the RVLM during all three phases of endotoxemia.

Negative_regulation (depression) of Complexes I + III in RVLM associated with endotoxemia, rostral ventrolateral medulla and depression

2) Confidence 0.08 Published 2002 Journal J. Biomed. Sci. Section Abstract Doc Link 12372992 Disease Relevance 0.63 Pain Relevance 0.37

General Comments

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