INT105726

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Context Info
Confidence 0.04
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.62
Pain Relevance 0.04

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extracellular region (Pdyn) lyase activity (Ddc) plasma membrane (Pdyn)
intracellular (Ddc) cellular amino acid metabolic process (Ddc) cytoplasm (Ddc)
Ddc (Rattus norvegicus)
Pdyn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 1 76.40 Quite High
Enkephalin 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Dyskinesias 6 99.26 Very High Very High Very High
Disease 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One of the most prominent molecular changes underlying the development of dyskinesia in the rat consists in the striatal induction of prodynorphin gene expression by L-DOPA.
L-DOPA Positive_regulation (induction) of Gene_expression (expression) of prodynorphin gene associated with dyskinesias
1) Confidence 0.04 Published 2002 Journal Amino Acids Section Abstract Doc Link 12373525 Disease Relevance 0.62 Pain Relevance 0.04

General Comments

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