INT105729

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Context Info
Confidence 0.38
First Reported 2002
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.08
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grin2a) plasma membrane (Grin2a) locomotion (Grin2a)
Grin2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 19 100.00 Very High Very High Very High
long-term potentiation 118 97.28 Very High Very High Very High
nMDA receptor 52 92.80 High High
Spinal cord 4 89.84 High High
Pain 1 82.68 Quite High
gABA 1 72.56 Quite High
Hippocampus 21 68.16 Quite High
Pyramidal cell 7 67.32 Quite High
Action potential 3 60.24 Quite High
Glutamate 6 42.72 Quite Low
Disease Link Frequency Relevance Heat
Pain 2 82.68 Quite High
Anxiety Disorder 47 50.00 Quite Low
Injury 2 37.92 Quite Low
Death 3 37.12 Quite Low
Depression 44 31.44 Quite Low
Drug Induced Neurotoxicity 8 5.00 Very Low Very Low Very Low
INFLAMMATION 7 5.00 Very Low Very Low Very Low
Kernicterus 7 5.00 Very Low Very Low Very Low
Li-fraumeni Syndrome 6 5.00 Very Low Very Low Very Low
Cognitive Disorder 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Formalin treatment did not affect NR1 splice variant expression but significantly increased and decreased the proportion of NR2A and NR2C, respectively.
Neg (not) Negative_regulation (decreased) of Localization (proportion) of NR2A
1) Confidence 0.38 Published 2002 Journal Amino Acids Section Abstract Doc Link 12373534 Disease Relevance 0.08 Pain Relevance 0.40
Bath application of the NR2A relatively selective antagonist NVP-AAM077 (0.3 ?
Negative_regulation (antagonist) of Localization (selective) of NR2A associated with antagonist
2) Confidence 0.35 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0 Pain Relevance 0.51
Using antibodies that selectively label NR1, NR2A, or NR2B subunits, we found that the protein levels of NR1, NR2A, and NR2B subunits were significantly decreased by 10 ┬ÁM UCB treatment for 24 or 48 h (Figure 4).
Negative_regulation (decreased) of Localization (levels) of NR2A
3) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690688 Disease Relevance 0 Pain Relevance 0.37

General Comments

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