INT105730

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Context Info
Confidence 0.67
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 0.64
Pain Relevance 2.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grin2a) plasma membrane (Grin2a) locomotion (Grin2a)
Anatomy Link Frequency
spike 1
hippocampus 1
Grin2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 43 100.00 Very High Very High Very High
long-term potentiation 338 99.84 Very High Very High Very High
Hippocampus 37 99.66 Very High Very High Very High
depression 246 97.36 Very High Very High Very High
nMDA receptor 81 92.80 High High
Spinal cord 4 89.84 High High
Pyramidal cell 10 83.20 Quite High
Pain 1 82.12 Quite High
addiction 4 76.40 Quite High
gABA 1 72.56 Quite High
Disease Link Frequency Relevance Heat
Depression 246 97.36 Very High Very High Very High
Pain 3 82.12 Quite High
Hypoxia 144 61.84 Quite High
Anxiety Disorder 94 50.00 Quite Low
Injury 3 34.08 Quite Low
Death 4 33.28 Quite Low
Stress 5 6.92 Low Low
Anaerobic Bacterial Infections 20 5.00 Very Low Very Low Very Low
Li-fraumeni Syndrome 10 5.00 Very Low Very Low Very Low
Ganglion Cysts 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Formalin treatment did not affect NR1 splice variant expression but significantly increased and decreased the proportion of NR2A and NR2C, respectively.
Localization (proportion) of NR2A
1) Confidence 0.67 Published 2002 Journal Amino Acids Section Abstract Doc Link 12373534 Disease Relevance 0.08 Pain Relevance 0.40
Thus, it has been shown that LTP in the hippocampus is specifically related to NR2A-containing NMDARs [18].
Localization (related) of NR2A-containing in hippocampus associated with hippocampus and long-term potentiation
2) Confidence 0.64 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1959237 Disease Relevance 0.24 Pain Relevance 0.57
Bath application of the NR2A relatively selective antagonist NVP-AAM077 (0.3 ?
Localization (selective) of NR2A associated with antagonist
3) Confidence 0.62 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0 Pain Relevance 0.51
These results provide evidence that both NR2B- and NR2A-NMDARs contribute to LTP induced by spike-timing protocol.


Localization (contribute) of NR2A-NMDARs in spike associated with long-term potentiation
4) Confidence 0.62 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0 Pain Relevance 0.46
After recording such NMDA-EPSPs for 30–60 min, the NR2A antagonist NVP (0.4 ?
Localization (0.4) of NR2A associated with antagonist
5) Confidence 0.56 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1959237 Disease Relevance 0.20 Pain Relevance 0.15
Using antibodies that selectively label NR1, NR2A, or NR2B subunits, we found that the protein levels of NR1, NR2A, and NR2B subunits were significantly decreased by 10 µM UCB treatment for 24 or 48 h (Figure 4).
Localization (levels) of NR2A
6) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690688 Disease Relevance 0 Pain Relevance 0.34
We found 22 of these genes were represented on our focused array (GPR51, GRIA3, GRIA4, GRID2, GRIK 1, GRIK3, GRIK4, GRIN1, GRIN2A GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, and GUCY2F).
Localization (array) of GRIN2A GRIN2B
7) Confidence 0.25 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.11 Pain Relevance 0.13

General Comments

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