INT10574

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Context Info
Confidence 0.44
First Reported 1982
Last Reported 2000
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0.18
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Cyp21a1)
Anatomy Link Frequency
nerve 2
plasma 1
Cyp21a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 8 99.16 Very High Very High Very High
tetrodotoxin 2 89.56 High High
Neurotransmitter 8 80.64 Quite High
dexamethasone 2 75.00 Quite High
halothane 2 60.40 Quite High
anesthesia 2 59.60 Quite High
Disease Link Frequency Relevance Heat
Toxicity 2 91.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
From the hepatic cytochrome P-450 isozymes b and c isolated from rats treated with phenobarbital and 3-methylcholanthrene respectively, only cytochrome P-450c was found to be active in the oxidation of paracetamol, in the presence of glutathione ultimately leading to the formation of the 3-glutathionyl conjugate.
Positive_regulation (active) of cytochrome P-450c associated with paracetamol
1) Confidence 0.44 Published 1987 Journal Xenobiotica Section Abstract Doc Link 3825173 Disease Relevance 0 Pain Relevance 0.40
Additions of ascorbate, menadione, thiol-containing amino acids and glutathione (GSH) led to an increased stability of N-OH-pHAA, reduced the covalent binding of N-OH-pHAA to cellular protein and decreased GSH depletion caused by N-OH-pHAA.
Positive_regulation (stability) of N-OH-pHAA
2) Confidence 0.37 Published 1982 Journal Acta Pharmacol Toxicol (Copenh) Section Abstract Doc Link 7113726 Disease Relevance 0.09 Pain Relevance 0.09
Additions of ascorbate, menadione, thiol-containing amino acids and glutathione (GSH) led to an increased stability of N-OH-pHAA, reduced the covalent binding of N-OH-pHAA to cellular protein and decreased GSH depletion caused by N-OH-pHAA.
Positive_regulation (increased) of N-OH-pHAA
3) Confidence 0.37 Published 1982 Journal Acta Pharmacol Toxicol (Copenh) Section Abstract Doc Link 7113726 Disease Relevance 0.09 Pain Relevance 0.09
PYR, HQ and C-PTIO reduced significantly GSNO- and NO- induced relaxations but did not affect those induced by NH2OH or nerve activation.
Positive_regulation (activation) of NH2OH in nerve
4) Confidence 0.05 Published 2000 Journal Life Sci. Section Abstract Doc Link 11205885 Disease Relevance 0 Pain Relevance 0.19
The catalase inhibitor 1,2,4 aminotriazole failed to affect nerve and NH2OH induced relaxations.
Neg (failed) Positive_regulation (induced) of NH2OH in nerve
5) Confidence 0.05 Published 2000 Journal Life Sci. Section Abstract Doc Link 11205885 Disease Relevance 0 Pain Relevance 0.19
Concurrent with the rise in fetal plasma cortisol, adrenocortical steroid hydroxylase enzyme activity increases.
Positive_regulation (increases) of steroid hydroxylase in plasma
6) Confidence 0.01 Published 1992 Journal Endocrinology Section Abstract Doc Link 1505467 Disease Relevance 0 Pain Relevance 0.13

General Comments

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